TW200836735A - Macrocyclic factor VIIA inhibitors useful as anticoagulants - Google Patents

Info

Publication number

TW200836735A

TW200836735A TW096148731A TW96148731A TW200836735A TW 200836735 A TW200836735 A TW 200836735A TW 096148731 A TW096148731 A TW 096148731A TW 96148731 A TW96148731 A TW 96148731A TW 200836735 A TW200836735 A TW 200836735A

Authority

TW

Taiwan

Prior art keywords

substituted

group

alkyl

heterocyclic ring

nrcrd

Prior art date

2006-12-20

Links

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• Global Dossier
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• 239000003146 anticoagulant agent Substances 0.000 title description 29
• 229940127219 anticoagulant drug Drugs 0.000 title description 18
• 229940082863 Factor VIIa inhibitor Drugs 0.000 title 1
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• 150000003839 salts Chemical class 0.000 claims abstract description 55
• 229940002612 prodrug Drugs 0.000 claims abstract description 41
• 239000000651 prodrug Substances 0.000 claims abstract description 41
• 239000012453 solvate Substances 0.000 claims abstract description 32
• -1 substituted Chemical class 0.000 claims description 139
• 125000000217 alkyl group Chemical group 0.000 claims description 111
• 125000000623 heterocyclic group Chemical group 0.000 claims description 104
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 94
• 208000007536 Thrombosis Diseases 0.000 claims description 83
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 75
• 229910052799 carbon Inorganic materials 0.000 claims description 74
• 239000003795 chemical substances by application Substances 0.000 claims description 59
• 125000005842 heteroatom Chemical group 0.000 claims description 58
• 229910052794 bromium Inorganic materials 0.000 claims description 52
• 229910052801 chlorine Inorganic materials 0.000 claims description 52
• 229910052739 hydrogen Inorganic materials 0.000 claims description 49
• 229910052731 fluorine Inorganic materials 0.000 claims description 44
• 150000001721 carbon Chemical group 0.000 claims description 42
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 40
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• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 29
• 229910052757 nitrogen Inorganic materials 0.000 claims description 29
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• NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 20
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