TW200704778A - Screening using polarization anisotropy in fret emissions - Google Patents

Screening using polarization anisotropy in fret emissions

Info

Publication number
TW200704778A
TW200704778A TW095111992A TW95111992A TW200704778A TW 200704778 A TW200704778 A TW 200704778A TW 095111992 A TW095111992 A TW 095111992A TW 95111992 A TW95111992 A TW 95111992A TW 200704778 A TW200704778 A TW 200704778A
Authority
TW
Taiwan
Prior art keywords
fluorophore
chemical entity
chemical
fret
entities
Prior art date
Application number
TW095111992A
Other languages
English (en)
Chinese (zh)
Inventor
Steven C Miller
Paul B Comita
Christopher B Shumate
Evan F Cromwell
Original Assignee
Blueshift Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blueshift Biotechnologies Inc filed Critical Blueshift Biotechnologies Inc
Publication of TW200704778A publication Critical patent/TW200704778A/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW095111992A 2005-04-04 2006-04-04 Screening using polarization anisotropy in fret emissions TW200704778A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66842805P 2005-04-04 2005-04-04
US67884205P 2005-05-06 2005-05-06

Publications (1)

Publication Number Publication Date
TW200704778A true TW200704778A (en) 2007-02-01

Family

ID=37073796

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095111992A TW200704778A (en) 2005-04-04 2006-04-04 Screening using polarization anisotropy in fret emissions

Country Status (5)

Country Link
US (2) US20060234279A1 (enExample)
EP (1) EP1866443A4 (enExample)
JP (1) JP4921458B2 (enExample)
TW (1) TW200704778A (enExample)
WO (1) WO2006107864A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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CN102548466A (zh) * 2009-07-28 2012-07-04 霍夫曼-拉罗奇有限公司 非侵入性体内光学成像方法
TWI808554B (zh) * 2020-12-04 2023-07-11 亞光股份有限公司 使用陰極發光測量判別半導體材料中的位錯類型和密度的裝置與方法
US11782001B2 (en) 2020-12-04 2023-10-10 Attolight AG Dislocation type and density discrimination in semiconductor materials using cathodoluminescence measurements

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EP1866443A4 (en) * 2005-04-04 2009-04-08 Blueshift Biotechnologies Inc SCREENING USING POLARIZATION ANISOTROPY FOR FRET EMISSIONS
JP5189301B2 (ja) * 2007-03-12 2013-04-24 オリンパス株式会社 レーザー走査型顕微鏡
KR101679088B1 (ko) 2008-10-01 2016-12-06 셔윈 화 척추골의 전선-유도식 척추경 나사 고정 시스템 및 방법
JP5627667B2 (ja) 2009-04-03 2014-11-19 ハーデンブルック、ミッチェル エイ．ＨＡＲＤＥＮＢＲＯＯＫ，Ｍｉｔｃｈｅｌｌ Ａ． 外科的開創器アセンブリ
MX2012011091A (es) 2010-03-26 2013-03-07 Echostar Technologies Llc Receptor de television de entrada multiple.
KR101814838B1 (ko) 2010-03-30 2018-01-03 셔윈 화 척추의 척추경 나사 안정화를 위한 시스템 및 방법
US8569254B2 (en) 2010-12-10 2013-10-29 National Yang Ming University Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
WO2012120004A1 (en) 2011-03-07 2012-09-13 F. Hoffmann-La Roche Ag In vivo selection of therapeutically active antibodies
JP6100704B2 (ja) 2011-03-07 2017-03-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 治療用抗体についてのインビボ試験の手段および方法
KR101167649B1 (ko) 2011-04-20 2012-07-20 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 장치
WO2012154858A1 (en) * 2011-05-09 2012-11-15 Whitehead Institute For Biomedical Research Chaperone interaction assays and uses thereof
JP5877741B2 (ja) * 2012-03-16 2016-03-08 株式会社日立製作所 細胞数モニタリング方法
WO2014059281A1 (en) * 2012-10-11 2014-04-17 The Regents Of The University Of Michigan Fluorescence polarization assay for detecting high molecular weight molecules in biological fluids
CN102967554B (zh) * 2012-10-29 2016-12-21 广东工业大学 一种双通道、单光路结构的荧光各向异性显微成像装置及方法
CN113073129A (zh) * 2013-10-25 2021-07-06 拜奥麦迪逊公司 双荧光团的酶测定法
WO2016116291A1 (de) * 2015-01-23 2016-07-28 Bayer Cropscience Ag Verfahren und vorrichtung zur ermittlung der wirkung von wirkstoffen an nematoden und anderen organismen in wässrigen tests
CN109509509B (zh) * 2018-09-29 2020-12-22 江西理工大学 基于动态加权蛋白质相互作用网络的蛋白质复合物挖掘方法
US11160580B2 (en) 2019-04-24 2021-11-02 Spine23 Inc. Systems and methods for pedicle screw stabilization of spinal vertebrae
WO2021092495A1 (en) 2019-11-08 2021-05-14 Spine 23, Inc. Systems and methods for pedicle screw stabilization of spinal vertebrae
ES3058598T3 (en) 2019-11-27 2026-03-11 Spine23 Inc Systems for treating a lateral curvature of a spine
KR20240049213A (ko) 2021-05-12 2024-04-16 스파인23 인코포레이티드 척추뼈의 척추경 나사를 안정화시키기 위한 시스템 및 방법
US12631561B2 (en) * 2021-08-19 2026-05-19 Rizer Biotech Ab Selective time-resolved fluorescence anisotropy with switchable states

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US5524405A (en) 1994-02-28 1996-06-11 Byrd; Randall Wall structure
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5597696A (en) * 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US6573045B1 (en) * 1998-06-05 2003-06-03 Ribotargets, Ltd. Methods and kits for discovery of RNA-binding compounds
CA2377560C (en) * 1999-06-24 2010-08-24 Mcmaster University Incorporation and applications of biomolecular interactions within a carrier
US6509161B1 (en) * 2000-02-29 2003-01-21 Gentronix Limited Green fluorescent protein
AU6152301A (en) * 2000-05-12 2001-11-26 Caliper Techn Corp Detection of nucleic acid hybridization by fluorescence polarization
WO2002103321A2 (en) * 2001-06-14 2002-12-27 Anadys Pharmaceuticals, Inc. Methods of screening for ligands of target molecules
US20030228703A1 (en) * 2002-04-05 2003-12-11 The Regents Of The University Of Michigan Fluorescence resonance energy transfer quantitation and stoichiometry in living cells
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
US6713262B2 (en) * 2002-06-25 2004-03-30 Agilent Technologies, Inc. Methods and compositions for high throughput identification of protein/nucleic acid binding pairs
JP2004093527A (ja) * 2002-09-04 2004-03-25 Center For Advanced Science & Technology Incubation Ltd 蛍光共鳴エネルギー転移を用いた蛋白質の分析方法
JP4214206B2 (ja) * 2002-12-10 2009-01-28 独立行政法人理化学研究所 Ｆｒｅｔを利用した蛍光指示薬
WO2005019811A2 (en) 2003-08-26 2005-03-03 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
US20050264805A1 (en) 2004-02-09 2005-12-01 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
FR2872287B1 (fr) * 2004-06-28 2007-03-16 Cis Bio Internat Sa Procede d'amelioration de la detection des signaux de fluorescence lors d'un transfert d'energie non radiatif
US7141378B2 (en) * 2004-07-02 2006-11-28 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
US8031338B2 (en) * 2004-12-02 2011-10-04 Vanderbilt University Measuring Forster resonance energy transfer with polarized and depolarized light
EP1866443A4 (en) * 2005-04-04 2009-04-08 Blueshift Biotechnologies Inc SCREENING USING POLARIZATION ANISOTROPY FOR FRET EMISSIONS
JP5189301B2 (ja) * 2007-03-12 2013-04-24 オリンパス株式会社 レーザー走査型顕微鏡

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548466A (zh) * 2009-07-28 2012-07-04 霍夫曼-拉罗奇有限公司 非侵入性体内光学成像方法
TWI808554B (zh) * 2020-12-04 2023-07-11 亞光股份有限公司 使用陰極發光測量判別半導體材料中的位錯類型和密度的裝置與方法
US11782001B2 (en) 2020-12-04 2023-10-10 Attolight AG Dislocation type and density discrimination in semiconductor materials using cathodoluminescence measurements

Also Published As

Publication number Publication date
EP1866443A4 (en) 2009-04-08
JP2008538004A (ja) 2008-10-02
EP1866443A1 (en) 2007-12-19
WO2006107864A1 (en) 2006-10-12
US20080206888A1 (en) 2008-08-28
US20060234279A1 (en) 2006-10-19
US7674588B2 (en) 2010-03-09
JP4921458B2 (ja) 2012-04-25

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