TW200631933A - Estrogen receptor modulators - Google Patents
Estrogen receptor modulatorsInfo
- Publication number
- TW200631933A TW200631933A TW094137372A TW94137372A TW200631933A TW 200631933 A TW200631933 A TW 200631933A TW 094137372 A TW094137372 A TW 094137372A TW 94137372 A TW94137372 A TW 94137372A TW 200631933 A TW200631933 A TW 200631933A
- Authority
- TW
- Taiwan
- Prior art keywords
- disease
- compounds
- bone
- receptor modulators
- estrogen receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
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- C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
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- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/86—Ring systems containing bridged rings containing four rings
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
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- C07C2603/96—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members
- C07C2603/97—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members containing five-membered rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62391004P | 2004-11-01 | 2004-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200631933A true TW200631933A (en) | 2006-09-16 |
Family
ID=35759216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094137372A TW200631933A (en) | 2004-11-01 | 2005-10-25 | Estrogen receptor modulators |
Country Status (16)
Country | Link |
---|---|
US (1) | US7151196B2 (zh) |
EP (1) | EP1809594A1 (zh) |
JP (1) | JP2008518960A (zh) |
KR (1) | KR20070083896A (zh) |
CN (1) | CN101068764B (zh) |
AR (1) | AR051597A1 (zh) |
AU (1) | AU2005302143A1 (zh) |
BR (1) | BRPI0517224A (zh) |
CA (1) | CA2585658A1 (zh) |
IL (1) | IL182829A0 (zh) |
MX (1) | MX2007005267A (zh) |
NO (1) | NO20072771L (zh) |
PE (1) | PE20060610A1 (zh) |
RU (1) | RU2007120392A (zh) |
TW (1) | TW200631933A (zh) |
WO (1) | WO2006050402A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2498339A1 (en) * | 2002-09-19 | 2004-04-01 | Merck & Co., Inc. | Estrogen receptor modulators |
JP2008518959A (ja) * | 2004-11-01 | 2008-06-05 | メルク エンド カムパニー インコーポレーテッド | 1,5−二置換−2−ヒドロキシ−ジバテトラエン−6−オンの合成 |
WO2006062876A2 (en) * | 2004-12-09 | 2006-06-15 | Merck & Co., Inc. | Estrogen receptor modulators |
US7709508B2 (en) * | 2004-12-09 | 2010-05-04 | Merck Sharp & Dohme | Estrogen receptor modulators |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
WO2008091555A2 (en) | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
US9212179B2 (en) | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
US9233941B2 (en) | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
US9085566B2 (en) | 2007-02-02 | 2015-07-21 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and related disorders |
CA2677264C (en) * | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
CA2702710C (en) | 2007-10-16 | 2013-05-07 | Repros Therapeutics, Inc. | Trans-clomiphene for metabolic syndrome |
CA2709677C (en) | 2007-12-21 | 2017-03-14 | Lin Zhi | Selective androgen receptor modulators (sarms) and uses thereof |
US20100087402A1 (en) * | 2008-09-29 | 2010-04-08 | Vivus, Inc. | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders |
ES2681023T3 (es) | 2012-02-29 | 2018-09-11 | Repros Therapeutics Inc. | Terapia de combinación para tratar el déficit de andrógenos |
US9359315B2 (en) * | 2013-09-10 | 2016-06-07 | Arrien Pharmaceuticals Llc | Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis |
CN108348605B (zh) | 2015-11-10 | 2023-06-09 | 帕拉卡林治疗公司 | 用pdgf-cc抑制剂和抗雌激素治疗er阴性乳癌 |
CN110317179B (zh) * | 2018-03-29 | 2023-01-24 | 云南大学 | 类赤霉素化合物、其制备方法、药物组合物及应用及其中间体 |
WO2022140667A2 (en) * | 2020-12-23 | 2022-06-30 | Icahn School Of Medicine At Mount Sinai | Method for treating crohn's disease |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377354A (en) | 1979-06-14 | 1983-03-22 | Conoco Inc. | Flow line bundle and method of towing same |
US4317922A (en) | 1979-10-19 | 1982-03-02 | Merck & Co., Inc. | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives |
US4356313A (en) | 1979-10-19 | 1982-10-26 | Merck & Co., Inc. | [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts |
US4356314A (en) | 1980-06-30 | 1982-10-26 | Merck & Co., Inc. | [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives |
US4316043A (en) | 1980-12-19 | 1982-02-16 | Merck & Co., Inc. | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives |
US4604396A (en) | 1985-09-26 | 1986-08-05 | Merck & Co., Inc. | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts |
US4704472A (en) | 1985-12-18 | 1987-11-03 | Merck & Co., Inc. | Preparation of an enantiomer of a substituted fluorenyloxyacetic acid |
US4731472A (en) | 1986-03-03 | 1988-03-15 | Merck & Co., Inc. | (5,6-dichloro-3-oxo-9A-propyl-2,3,9,9A-tetrahydrofluoren-7-yl)alkanoic acids and alkanimidamides |
US4835313A (en) | 1986-03-03 | 1989-05-30 | Merck & Co., Inc. | (5,6-dichloro-3-oxo-9α-propyl-2,3,9,9α-tetrahydrofluoren-7-yl) alkanimidamides |
US4675341A (en) | 1986-08-13 | 1987-06-23 | Merck & Co., Inc. | [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol and its derivatives |
US4797391A (en) | 1986-09-24 | 1989-01-10 | Merck & Co., Inc. | ((5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides |
US4731471A (en) | 1986-11-03 | 1988-03-15 | Merck & Co., Inc. | (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents |
US4731470A (en) | 1986-11-03 | 1988-03-15 | Merck & Co., Inc. | [(5,6-dichloro-3-oxo-2,9a-alkano-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]alkanoic acids and alkanimidamides |
US6251898B1 (en) | 1999-08-24 | 2001-06-26 | Questcor Pharmaceuticals, Inc. | Medical use of fluorenone derivatives for treating and preventing brain and spinal injury |
EP1257264B1 (en) * | 2000-02-14 | 2011-09-14 | Merck Sharp & Dohme Corp. | Estrogen receptor modulators |
-
2005
- 2005-10-24 AR ARP050104441A patent/AR051597A1/es not_active Application Discontinuation
- 2005-10-25 TW TW094137372A patent/TW200631933A/zh unknown
- 2005-10-28 JP JP2007539314A patent/JP2008518960A/ja not_active Withdrawn
- 2005-10-28 CN CN200580038177XA patent/CN101068764B/zh not_active Expired - Fee Related
- 2005-10-28 MX MX2007005267A patent/MX2007005267A/es not_active Application Discontinuation
- 2005-10-28 PE PE2005001265A patent/PE20060610A1/es not_active Application Discontinuation
- 2005-10-28 US US11/261,692 patent/US7151196B2/en not_active Expired - Fee Related
- 2005-10-28 WO PCT/US2005/039578 patent/WO2006050402A1/en active Application Filing
- 2005-10-28 KR KR1020077009961A patent/KR20070083896A/ko not_active Application Discontinuation
- 2005-10-28 CA CA002585658A patent/CA2585658A1/en not_active Abandoned
- 2005-10-28 RU RU2007120392/04A patent/RU2007120392A/ru unknown
- 2005-10-28 EP EP05819550A patent/EP1809594A1/en not_active Withdrawn
- 2005-10-28 BR BRPI0517224-1A patent/BRPI0517224A/pt not_active Application Discontinuation
- 2005-10-28 AU AU2005302143A patent/AU2005302143A1/en not_active Abandoned
-
2007
- 2007-04-26 IL IL182829A patent/IL182829A0/en unknown
- 2007-05-31 NO NO20072771A patent/NO20072771L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101068764A (zh) | 2007-11-07 |
AU2005302143A1 (en) | 2006-05-11 |
JP2008518960A (ja) | 2008-06-05 |
CA2585658A1 (en) | 2006-05-11 |
WO2006050402A1 (en) | 2006-05-11 |
RU2007120392A (ru) | 2008-12-10 |
PE20060610A1 (es) | 2006-08-11 |
MX2007005267A (es) | 2007-07-09 |
BRPI0517224A (pt) | 2008-09-30 |
CN101068764B (zh) | 2011-06-08 |
US20060094779A1 (en) | 2006-05-04 |
KR20070083896A (ko) | 2007-08-24 |
EP1809594A1 (en) | 2007-07-25 |
NO20072771L (no) | 2007-07-18 |
US7151196B2 (en) | 2006-12-19 |
AR051597A1 (es) | 2007-01-24 |
IL182829A0 (en) | 2007-08-19 |
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