WO2004073612A3 - Estrogen receptor modulators - Google Patents

Estrogen receptor modulators Download PDF

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Publication number
WO2004073612A3
WO2004073612A3 PCT/US2004/003723 US2004003723W WO2004073612A3 WO 2004073612 A3 WO2004073612 A3 WO 2004073612A3 US 2004003723 W US2004003723 W US 2004003723W WO 2004073612 A3 WO2004073612 A3 WO 2004073612A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
estrogen
compounds
receptor modulators
estrogen receptor
Prior art date
Application number
PCT/US2004/003723
Other languages
French (fr)
Other versions
WO2004073612A2 (en
Inventor
Wanying Sun
Lovji D Cama
Original Assignee
Merck & Co Inc
Wanying Sun
Lovji D Cama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Wanying Sun, Lovji D Cama filed Critical Merck & Co Inc
Publication of WO2004073612A2 publication Critical patent/WO2004073612A2/en
Publication of WO2004073612A3 publication Critical patent/WO2004073612A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Abstract

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer.
PCT/US2004/003723 2003-02-13 2004-02-09 Estrogen receptor modulators WO2004073612A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44716403P 2003-02-13 2003-02-13
US60/447,164 2003-02-13

Publications (2)

Publication Number Publication Date
WO2004073612A2 WO2004073612A2 (en) 2004-09-02
WO2004073612A3 true WO2004073612A3 (en) 2004-10-28

Family

ID=32908413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/003723 WO2004073612A2 (en) 2003-02-13 2004-02-09 Estrogen receptor modulators

Country Status (1)

Country Link
WO (1) WO2004073612A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
USRE46558E1 (en) 2005-04-28 2017-09-26 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
US8227007B2 (en) 2005-08-05 2012-07-24 T.F.H. Publications, Inc. Direct melt processing of resins
US8231920B2 (en) 2005-08-05 2012-07-31 T.F.H. Publications, Inc. Direct melt processing of resins
NL2000351C2 (en) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogen modulators.
BRPI0708318A2 (en) * 2006-02-28 2011-05-24 Paloma Pharmaceuticals Inc compositions and use of compounds to treat diseases characterized by cell proliferation and angiogenesis
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
EP2647376A1 (en) 2007-01-22 2013-10-09 Gtx, Inc. Nuclear receptor binding agents
JP5921235B2 (en) * 2011-02-09 2016-05-24 あゆみ製薬株式会社 3-Hydroxy-6H-benzo [c] chromen-6-one derivative and method for producing the same
US9381187B2 (en) 2011-02-16 2016-07-05 Paloma Pharmaceuticals, Inc. Radiation countermeasure agents
AU2012311702B2 (en) * 2011-09-22 2017-07-13 Merck Sharp & Dohme B.V. FSH receptor antagonists
EP3663287B1 (en) * 2013-12-23 2023-09-20 Amazentis SA Process scale synthesis of urolithins
PT3484880T (en) 2016-07-13 2020-12-07 Leo Pharma As Heteroaromatic modulators of the retinoid-related orphan receptor gamma
EP3592424A1 (en) * 2017-03-08 2020-01-15 Amazentis SA Methods for improving mitophagy in subjects
US11969408B2 (en) * 2017-03-08 2024-04-30 Amazentis Sa Method for improving mitophagy in subjects
AU2022212883A1 (en) 2021-01-27 2023-08-17 Vandria Sa Urolithin derivatives and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901925A (en) * 1972-08-29 1975-08-26 Boehringer Sohn Ingelheim 2-carboxy-4-oxo-4h,10h-(2)-benzopyrano-(4,3-g)-(1)-benzopyrans and salts thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901925A (en) * 1972-08-29 1975-08-26 Boehringer Sohn Ingelheim 2-carboxy-4-oxo-4h,10h-(2)-benzopyrano-(4,3-g)-(1)-benzopyrans and salts thereof

Also Published As

Publication number Publication date
WO2004073612A2 (en) 2004-09-02

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