WO2006081152A3 - Estrogen receptor modulators - Google Patents
Estrogen receptor modulators Download PDFInfo
- Publication number
- WO2006081152A3 WO2006081152A3 PCT/US2006/002148 US2006002148W WO2006081152A3 WO 2006081152 A3 WO2006081152 A3 WO 2006081152A3 US 2006002148 W US2006002148 W US 2006002148W WO 2006081152 A3 WO2006081152 A3 WO 2006081152A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disease
- estrogen
- compounds
- receptor modulators
- bone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Abstract
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget’s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease and cancer, in particular of the breast, uterus and prostate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64675405P | 2005-01-24 | 2005-01-24 | |
US60/646,754 | 2005-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006081152A2 WO2006081152A2 (en) | 2006-08-03 |
WO2006081152A3 true WO2006081152A3 (en) | 2007-02-08 |
Family
ID=36740963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/002148 WO2006081152A2 (en) | 2005-01-24 | 2006-01-20 | Estrogen receptor modulators |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006081152A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7273802B2 (en) | 2017-08-28 | 2023-05-15 | ゼジアン ジャーチ ディベロップメント ファーマシューティカルズ リミテッド | Asymmetric Synthesis of Compounds and Use in Disease Treatment |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
EP2647376A1 (en) | 2007-01-22 | 2013-10-09 | Gtx, Inc. | Nuclear receptor binding agents |
CN102558267A (en) * | 2012-01-13 | 2012-07-11 | 宜城市共同药业有限公司 | Preparation method of testosterone enanthate |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3218316A (en) * | 1963-08-26 | 1965-11-16 | Syntex Corp | 10beta-ethynyl-19-norandrostane derivatives |
-
2006
- 2006-01-20 WO PCT/US2006/002148 patent/WO2006081152A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3218316A (en) * | 1963-08-26 | 1965-11-16 | Syntex Corp | 10beta-ethynyl-19-norandrostane derivatives |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7273802B2 (en) | 2017-08-28 | 2023-05-15 | ゼジアン ジャーチ ディベロップメント ファーマシューティカルズ リミテッド | Asymmetric Synthesis of Compounds and Use in Disease Treatment |
Also Published As
Publication number | Publication date |
---|---|
WO2006081152A2 (en) | 2006-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase |
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