DE69629624D1 - Verbindungen mit stickstoffenthaltenden nichtbasischen Seitenketten und diese enthaltende Zubereitungen - Google Patents

Verbindungen mit stickstoffenthaltenden nichtbasischen Seitenketten und diese enthaltende Zubereitungen

Info

Publication number
DE69629624D1
DE69629624D1 DE69629624T DE69629624T DE69629624D1 DE 69629624 D1 DE69629624 D1 DE 69629624D1 DE 69629624 T DE69629624 T DE 69629624T DE 69629624 T DE69629624 T DE 69629624T DE 69629624 D1 DE69629624 D1 DE 69629624D1
Authority
DE
Germany
Prior art keywords
compounds
present
estrogen
nitrogen
side chains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69629624T
Other languages
English (en)
Other versions
DE69629624T2 (de
Inventor
Jeffrey Alan Dodge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69629624D1 publication Critical patent/DE69629624D1/de
Application granted granted Critical
Publication of DE69629624T2 publication Critical patent/DE69629624T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69629624T 1995-06-07 1996-05-30 Verbindungen mit stickstoffenthaltenden nichtbasischen Seitenketten und diese enthaltende Zubereitungen Expired - Fee Related DE69629624T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US476154 1990-02-07
US08/476,154 US5567828A (en) 1995-06-07 1995-06-07 Compounds and compositions with nitrogen-containing non-basic side

Publications (2)

Publication Number Publication Date
DE69629624D1 true DE69629624D1 (de) 2003-10-02
DE69629624T2 DE69629624T2 (de) 2004-06-17

Family

ID=23890713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69629624T Expired - Fee Related DE69629624T2 (de) 1995-06-07 1996-05-30 Verbindungen mit stickstoffenthaltenden nichtbasischen Seitenketten und diese enthaltende Zubereitungen

Country Status (7)

Country Link
US (2) US5567828A (de)
EP (1) EP0747377B1 (de)
JP (1) JPH09118676A (de)
AT (1) ATE248159T1 (de)
CA (1) CA2178184A1 (de)
DE (1) DE69629624T2 (de)
ES (1) ES2204999T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US6444688B1 (en) * 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5948796A (en) * 1996-10-10 1999-09-07 Eli Lilly And Company Benzo B!thiophene compounds, intermediates, formulations, and methods
JP2001522373A (ja) 1997-04-30 2001-11-13 イーライ・リリー・アンド・カンパニー 抗血栓剤
ES2232946T3 (es) 1997-04-30 2005-06-01 Eli Lilly And Company Agentes antitromboticos.
JP2002514217A (ja) 1997-04-30 2002-05-14 イーライ・リリー・アンド・カンパニー 抗血栓物質
JP2002513415A (ja) 1997-04-30 2002-05-08 イーライ・リリー・アンド・カンパニー 抗血栓剤
JP2001523253A (ja) * 1997-04-30 2001-11-20 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造のための中間体および方法
US5760030A (en) * 1997-06-30 1998-06-02 Eli Lilly And Company Benzothiophene compounds and methods of use
US5866561A (en) * 1997-08-21 1999-02-02 Scimed Life Systems, Inc. Local delivery of estrogen for angiogenesis
AU2212699A (en) * 1998-01-15 1999-08-02 Icn Pharmaceuticals, Inc. Use of 8-cl-camp in prevention of restenosis of arterial walls
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
EP0997460B1 (de) * 1998-10-28 2002-12-11 Eli Lilly And Company Benzothiophenderivate als antithrombotische Mitteln und Zwischenprodukte
CA2366774A1 (en) 1999-04-02 2000-10-12 Center For Molecular Medicine And Immunology Method of detecting endometriosis
US6988141B1 (en) * 2000-05-17 2006-01-17 Ricoh Company, Ltd. Method and system of remote diagnostic, control and information collection using a dynamic linked library of multiple formats and multiple protocols with restriction on protocol
CA2444787A1 (en) * 2001-05-22 2002-11-28 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
DE60210283T2 (de) 2001-05-22 2006-11-09 Eli Lilly And Co., Indianapolis 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
DE602004016331D1 (de) * 2003-06-10 2008-10-16 Lilly Co Eli Pentafluoroalkylsulfin-naphthaline und und darauf bezogene modulatoren des östrogenrezeptors
US7655700B2 (en) 2005-08-25 2010-02-02 Michigan State University Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles
CA2802761C (en) 2010-06-16 2017-01-03 Endorecherche, Inc. Methods of treating or preventing estrogen-related diseases
CN104031022A (zh) * 2014-03-20 2014-09-10 浙江省医学科学院 盐酸雷洛昔芬的关键中间体及其中间产物的制备方法
CN116813603A (zh) * 2023-06-02 2023-09-29 成都市第三人民医院 一种选择性雌激素受体α降解化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE339235B (de) * 1965-06-01 1971-10-04 Haessle Ab
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
EP0062503A1 (de) * 1981-04-03 1982-10-13 Eli Lilly And Company Benzothiophen-Verbindungen und Verfahren zu ihrer Herstellung
JPS63139180A (ja) * 1986-12-02 1988-06-10 Tanabe Seiyaku Co Ltd カルボン酸誘導体
AU2543388A (en) * 1987-09-30 1989-04-18 University Of Tennessee Research Corporation, The Certain 3-substituted 2-alkyl benzothiophene derivatives
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
FR2694983B1 (fr) * 1992-08-18 1994-10-14 Schlumberger Ind Sa Procédé et dispositif pour la régulation optimale de la température interne d'un local.
JPH0675772A (ja) * 1992-08-26 1994-03-18 Omron Corp メンバーシップ関数自動作成装置および方法
TW234123B (de) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5554600A (en) * 1995-01-20 1996-09-10 Eli Lilly And Company Methods for inhibiting endometriosis
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds

Also Published As

Publication number Publication date
CA2178184A1 (en) 1996-12-08
US5631247A (en) 1997-05-20
US5567828A (en) 1996-10-22
EP0747377B1 (de) 2003-08-27
ATE248159T1 (de) 2003-09-15
ES2204999T3 (es) 2004-05-01
EP0747377A1 (de) 1996-12-11
DE69629624T2 (de) 2004-06-17
JPH09118676A (ja) 1997-05-06

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee