MX9706738A - Nuevos compuestos farmaceuticos de benzofurano. - Google Patents
Nuevos compuestos farmaceuticos de benzofurano.Info
- Publication number
- MX9706738A MX9706738A MX9706738A MX9706738A MX9706738A MX 9706738 A MX9706738 A MX 9706738A MX 9706738 A MX9706738 A MX 9706738A MX 9706738 A MX9706738 A MX 9706738A MX 9706738 A MX9706738 A MX 9706738A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- progestin
- estrogen
- formula
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona un compuesto de la formula (I) en donde R1 es hidrogeno, OH, halo, OCO(alquilo de 1 a 6 átomos de carbono), OCO(arilo), OSO2(alquilo de 4 a 6 átomos de carbono), OCOO(alquilo de 1 a 6 átomos de carbono), OCOO(arilo), OCONH(alquilo de 1 a 6 átomos de carbono), o OCON(alquilo de 1 a 6 átomos de carbono)2; R2 es arilo, alquilo de 1 a 6 átomos de carbono, cicloalquilo de 3 a 6 átomos de carbono, o 4-ciclohexanol; R3 es O(CH2)2 o O(CH2)3; R4 y R5 son opcionalmente CO(CH2)2CH3, CO(CH2)3CH3, alquilo de 1 a 6 átomos de carbono, o R4 y R5 se combinan para formar, con el nitrogeno, al cual están unidos, piperidina, morfolina, pirrolidina, 3-metilpirrolidina, 3,3-dimetilpirrolidina, 3,4-dimetilpirrolidina, azepina, o pipecolina; R6 es =C=CH2, =CH(alquilo de 1 a 5 átomos de carbono), =CH(alquenilo de 2 a 5 átomos de carbono), =C=CH(alquilo de 1 a 5 átomos de carbono), =CH(arilo), =C(OH) (alquilo de 1 a 5 átomos de carbono), =C(OH) (alquenilo de 2 a 5 átomos de carbono), =C(OH)arilo; y las sales farmacéuticamente aceptables de los mismos. La presente invencion proporciona además las composiciones farmacéuticas que contienen los compuestos de la formula (I), que contienen opcionalmente estrogeno o progestina y el uso de tales compuestos solos, o en combinacion con estrogeno o progestina, para aliviar los síntomas del síndrome post-menopáusico, particularmente la osteoporosis, condiciones patologicas relacionadas al sistema cardiovascular, y cáncer dependiente del estrogeno. Como se utiliza en la presente, el término "progestina" incluyen los compuestos que tienen actividad progestacional tales como, por ejemplo, progesterona, noretilnodrel, nongestrel, acetato de megestrol, noretindrona y similares. Los compuestos de la presente invencion son también utiles para inhibir la enfermedad fibroide uterina y la endometriosis en mujeres, y la proliferacion de células del musculo liso aortico, particularmente restenosis, en humanos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/402,285 US5523309A (en) | 1995-03-10 | 1995-03-10 | Benzofuran pharmaceutical compounds |
| US08402285 | 1995-03-10 | ||
| PCT/US1996/003163 WO1996028152A1 (en) | 1995-03-10 | 1996-03-07 | Novel benzofuran pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9706738A true MX9706738A (es) | 1997-11-29 |
| MXPA97006738A MXPA97006738A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| PT731097E (pt) | 2000-07-31 |
| AU692690B2 (en) | 1998-06-11 |
| DE69606566D1 (de) | 2000-03-16 |
| IL117396A0 (en) | 1996-07-23 |
| DE69606566T2 (de) | 2000-06-29 |
| DK0731097T3 (da) | 2000-05-15 |
| CA2214450A1 (en) | 1996-09-19 |
| ZA961882B (en) | 1997-09-08 |
| ES2142021T3 (es) | 2000-04-01 |
| EP0731097A1 (en) | 1996-09-11 |
| WO1996028152A1 (en) | 1996-09-19 |
| EP0731097B1 (en) | 2000-02-09 |
| AU5187396A (en) | 1996-10-02 |
| BR9607774A (pt) | 1998-07-07 |
| JP2000510814A (ja) | 2000-08-22 |
| IL117396A (en) | 2000-01-31 |
| ATE189678T1 (de) | 2000-02-15 |
| GR3033326T3 (en) | 2000-09-29 |
| US5523309A (en) | 1996-06-04 |
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