DK0731097T3 - Hidtil ukendte farmaceutiske benzofuranforbindelser - Google Patents

Hidtil ukendte farmaceutiske benzofuranforbindelser

Info

Publication number
DK0731097T3
DK0731097T3 DK96301537T DK96301537T DK0731097T3 DK 0731097 T3 DK0731097 T3 DK 0731097T3 DK 96301537 T DK96301537 T DK 96301537T DK 96301537 T DK96301537 T DK 96301537T DK 0731097 T3 DK0731097 T3 DK 0731097T3
Authority
DK
Denmark
Prior art keywords
alkyl
new pharmaceutical
benzofuran compounds
dimethylpyrrolidino
chr
Prior art date
Application number
DK96301537T
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
Henry Uhlman Bryant
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0731097T3 publication Critical patent/DK0731097T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96301537T 1995-03-10 1996-03-06 Hidtil ukendte farmaceutiske benzofuranforbindelser DK0731097T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/402,285 US5523309A (en) 1995-03-10 1995-03-10 Benzofuran pharmaceutical compounds

Publications (1)

Publication Number Publication Date
DK0731097T3 true DK0731097T3 (da) 2000-05-15

Family

ID=23591296

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96301537T DK0731097T3 (da) 1995-03-10 1996-03-06 Hidtil ukendte farmaceutiske benzofuranforbindelser

Country Status (15)

Country Link
US (1) US5523309A (da)
EP (1) EP0731097B1 (da)
JP (1) JP2000510814A (da)
AT (1) ATE189678T1 (da)
AU (1) AU692690B2 (da)
BR (1) BR9607774A (da)
CA (1) CA2214450A1 (da)
DE (1) DE69606566T2 (da)
DK (1) DK0731097T3 (da)
ES (1) ES2142021T3 (da)
GR (1) GR3033326T3 (da)
IL (1) IL117396A (da)
PT (1) PT731097E (da)
WO (1) WO1996028152A1 (da)
ZA (1) ZA961882B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703407B1 (en) * 1994-09-20 2004-03-09 Eli Lilly And Company Benzofuran compounds, compositions, and methods
US6653328B1 (en) * 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
US6444688B1 (en) * 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
EP0863755B1 (en) * 1995-10-31 2004-12-15 Eli Lilly And Company Antithrombotic diamines
CA2214919A1 (en) * 1996-09-24 1998-03-24 Kenneth Lee Hauser Benzothiophene compounds, intermediates, processes, compositions, and methods
US6251901B1 (en) 1996-10-23 2001-06-26 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6342514B1 (en) 1996-10-23 2002-01-29 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6017940A (en) * 1996-10-23 2000-01-25 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5939444A (en) * 1996-10-23 1999-08-17 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US6153631A (en) * 1996-10-23 2000-11-28 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5965573A (en) * 1996-10-23 1999-10-12 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5990169A (en) * 1996-10-23 1999-11-23 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5922753A (en) * 1996-10-23 1999-07-13 Zymogenetics, Inc. Methods for treating bone deficit conditions with benzothiazole
US5948776A (en) * 1996-10-23 1999-09-07 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US5919808A (en) * 1996-10-23 1999-07-06 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
EP0973513A4 (en) * 1996-10-23 2003-03-19 Zymogenetics Inc COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH BONE DEFICIT
US6350774B1 (en) 1997-04-30 2002-02-26 Eli Lilly And Company Antithrombotic agents
AU7470098A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
EP0973517A4 (en) 1997-04-30 2002-07-24 Lilly Co Eli ANTITHROMBOTIC AGENTS
JP2001522373A (ja) 1997-04-30 2001-11-13 イーライ・リリー・アンド・カンパニー 抗血栓剤
FR2764800B1 (fr) * 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
ES2189355T3 (es) * 1998-10-28 2003-07-01 Lilly Co Eli Compuestos de benzotiofeno como agentes antitromboticos e intermedios.
FR2813306B1 (fr) * 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813307B1 (fr) * 2000-08-23 2002-11-08 Sanofi Synthelabo Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
ES2317935T3 (es) * 2000-10-05 2009-05-01 Takeda Pharmaceutical Company Limited Promotores de la proliferacion y diferenciacion de celulas pluripotenciales y/o celulas precursoras neuronales.
PT1401446E (pt) * 2001-05-22 2005-05-31 Lilly Co Eli Derivados de tetrahidroquinolina para a inibicao de doencas associadas com a privacao de estrogenio ou com uma resposta fisiologica aberrante ao estrogenio endogeno
DE60210283T2 (de) * 2001-05-22 2006-11-09 Eli Lilly And Co., Indianapolis 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
EP1631561B1 (en) * 2003-05-07 2010-08-18 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
EP1654245A1 (en) 2003-08-07 2006-05-10 Bayer Pharmaceuticals Corporation Benzofuran derivatives useful for treating hyper-proliferative disorders
CN114315774B (zh) * 2022-01-04 2023-05-09 山东第一医科大学(山东省医学科学院) Psf蛋白抑制剂、药物组合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes

Also Published As

Publication number Publication date
CA2214450A1 (en) 1996-09-19
IL117396A (en) 2000-01-31
EP0731097B1 (en) 2000-02-09
ATE189678T1 (de) 2000-02-15
US5523309A (en) 1996-06-04
WO1996028152A1 (en) 1996-09-19
GR3033326T3 (en) 2000-09-29
BR9607774A (pt) 1998-07-07
ES2142021T3 (es) 2000-04-01
EP0731097A1 (en) 1996-09-11
ZA961882B (en) 1997-09-08
JP2000510814A (ja) 2000-08-22
AU692690B2 (en) 1998-06-11
IL117396A0 (en) 1996-07-23
DE69606566T2 (de) 2000-06-29
MX9706738A (es) 1997-11-29
AU5187396A (en) 1996-10-02
PT731097E (pt) 2000-07-31
DE69606566D1 (de) 2000-03-16

Similar Documents

Publication Publication Date Title
DK0731097T3 (da) Hidtil ukendte farmaceutiske benzofuranforbindelser
BR9305182A (pt) Composto e formulação farmaceûtica
MX9603508A (es) Analogos de la doxiciclina.
HU9700579D0 (en) Novel prodrug for treating tumors and flogistic diseases
ES2069100T3 (es) Inmunosupresor y procedimiento para la produccion del mismo.
FI865320A0 (fi) Antibiotiska a 40926 n-acylaminoglukuronyl -aglykoner och antibiotisk a 40926 aglykon.
DE3783657D1 (de) Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
DE3856387T2 (de) 1,2,3,4,10,14b-HEXAHYDRODIBENZO-c,f]PYRAZINO-1,2-a]AZEPINO-DERIVATE
DE3687200T2 (de) Cephalosporinderivate.
DK0461574T3 (da) Lægemidler indeholdende 3,7-diazabicyclo(3,3,1)-nonanforbindelser
ATE62244T1 (de) Pyrrolo(1,2-a>(4,1>benzoxazepine, verfahren zur ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie therapeutische verwendung.
DE59712053D1 (de) 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE3889497D1 (de) 3,4-Dihydro-2-alkyl-3-oxo-N-aryl-2H-[1]benzothieno[3,2-e]-1,2-thiazine-4-carboxamid-1,1-dioxide.
ATA137591A (de) Verwendung eines antibiotikums des typs 2-desoxystreptamin
ES2063328T3 (es) Nuevo uso de naftoxazinas.
PT84328A (en) Heterocyclic compounds and their preparation and pharmaceutical formulation
IT1204458B (it) Derivati eterociclici
DE3369322D1 (en) Tricyclic triazino compounds, their use and formulation as pharmaceuticals and processes for their production
DE69305352D1 (de) Verfahren zur herstellung von 1,3-dioxolanderivaten
ATE111465T1 (de) Imidazobenzodiazepine und ihre salze, verfahren zur herstellung, verwendung als arzneimittel und diese substanzen enthaltende zusammensetzungen.
IT1201455B (it) Derivati piridinici sostituiti
FI922880A (fi) Antipsykotiska benzodioxanderivat
HUT48873A (en) Process for producing dihydropyridine derivatives and pharmaceutical compositions comprising these compounds as active ingredient