MX2007005267A - Moduladores de los receptores de estrogeno. - Google Patents

Moduladores de los receptores de estrogeno.

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Publication number
MX2007005267A
MX2007005267A MX2007005267A MX2007005267A MX2007005267A MX 2007005267 A MX2007005267 A MX 2007005267A MX 2007005267 A MX2007005267 A MX 2007005267A MX 2007005267 A MX2007005267 A MX 2007005267A MX 2007005267 A MX2007005267 A MX 2007005267A
Authority
MX
Mexico
Prior art keywords
disease
estrogen
bone
receptor modulators
impairment
Prior art date
Application number
MX2007005267A
Other languages
English (en)
Inventor
Robert R Wilkening
Amy Fried
Original Assignee
Merck & Co Inc
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Publication date
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Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX2007005267A publication Critical patent/MX2007005267A/es

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  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

La presente invencion se refiere a compuestos y sus derivados, su sintesis y su uso como moduladores de los receptores de estrogeno; los compuestos de la presente invencion son ligandos para los receptores de estrogeno y como tales pueden ser de utilidad para el tratamiento o prevencion de una variedad de afecciones relacionadas con las funciones del estrogeno que incluyen; perdida osea, fracturas oseas, osteoporosis, enfermedad osea metastasica, enfermedad de Paget, enfermedad periodontal, degeneracion del cartilago, endometriosis, enfermedad fibroide uterina, sofocos, niveles aumentados de colesterol LDL, enfermedad cardiovascular, deterioro de la funcion cognitiva, deterioro cognitivo leve asociado a la edad, trastornos degenerativos cerebrales, restenosis, ginecomastia, proliferacion de celulas de musculo liso vascular, obesidad, incontinencia, inflamacion, enfermedad inflamatoria del intestino, sindrome del intestino irritable, disfuncion sexual, hipertension, degeneracion retiniana y cancer, en particular de mama, utero y prostata.
MX2007005267A 2004-11-01 2005-10-28 Moduladores de los receptores de estrogeno. MX2007005267A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62391004P 2004-11-01 2004-11-01
PCT/US2005/039578 WO2006050402A1 (en) 2004-11-01 2005-10-28 Estrogen receptor modulators

Publications (1)

Publication Number Publication Date
MX2007005267A true MX2007005267A (es) 2007-07-09

Family

ID=35759216

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MX2007005267A MX2007005267A (es) 2004-11-01 2005-10-28 Moduladores de los receptores de estrogeno.

Country Status (16)

Country Link
US (1) US7151196B2 (es)
EP (1) EP1809594A1 (es)
JP (1) JP2008518960A (es)
KR (1) KR20070083896A (es)
CN (1) CN101068764B (es)
AR (1) AR051597A1 (es)
AU (1) AU2005302143A1 (es)
BR (1) BRPI0517224A (es)
CA (1) CA2585658A1 (es)
IL (1) IL182829A0 (es)
MX (1) MX2007005267A (es)
NO (1) NO20072771L (es)
PE (1) PE20060610A1 (es)
RU (1) RU2007120392A (es)
TW (1) TW200631933A (es)
WO (1) WO2006050402A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551820A2 (en) * 2002-09-19 2005-07-13 Merck & Co., Inc. Estrogen receptor modulators
AU2005302235A1 (en) * 2004-11-01 2006-05-11 Merck & Co., Inc. Synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones
US7511152B2 (en) * 2004-12-09 2009-03-31 Merck & Co., Inc. Estrogen receptor modulators
US7709508B2 (en) * 2004-12-09 2010-05-04 Merck Sharp & Dohme Estrogen receptor modulators
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
EA026578B1 (ru) 2007-01-22 2017-04-28 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9212179B2 (en) 2007-02-02 2015-12-15 Baylor College Of Medicine Compositions and methods for the treatment of metabolic disorders
US9233941B2 (en) 2007-02-02 2016-01-12 Baylor College Of Medicine Methods and compositions for the treatment of body weight related disorders
CN101674730B (zh) 2007-02-02 2014-09-10 贝勒医学院 用于治疗代谢疾病的组合物和方法
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
US9085566B2 (en) 2007-02-02 2015-07-21 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and related disorders
NZ591955A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for diabetes mellitus type 2
PT2222636E (pt) 2007-12-21 2013-07-16 Ligand Pharm Inc Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações
US20100087402A1 (en) * 2008-09-29 2010-04-08 Vivus, Inc. Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders
EP2819676B1 (en) 2012-02-29 2018-05-30 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
US9359315B2 (en) 2013-09-10 2016-06-07 Arrien Pharmaceuticals Llc Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
AU2016352592B2 (en) 2015-11-10 2023-04-27 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen
MA45780A (fr) 2016-07-29 2019-06-05 Janssen Pharmaceutica Nv Méthodes de traitement du cancer de la prostate
CN110317179B (zh) * 2018-03-29 2023-01-24 云南大学 类赤霉素化合物、其制备方法、药物组合物及应用及其中间体
WO2022140667A2 (en) * 2020-12-23 2022-06-30 Icahn School Of Medicine At Mount Sinai Method for treating crohn's disease

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377354A (en) 1979-06-14 1983-03-22 Conoco Inc. Flow line bundle and method of towing same
US4356313A (en) 1979-10-19 1982-10-26 Merck & Co., Inc. [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts
US4317922A (en) 1979-10-19 1982-03-02 Merck & Co., Inc. [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives
US4356314A (en) 1980-06-30 1982-10-26 Merck & Co., Inc. [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives
US4316043A (en) 1980-12-19 1982-02-16 Merck & Co., Inc. [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives
US4604396A (en) 1985-09-26 1986-08-05 Merck & Co., Inc. [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts
US4704472A (en) 1985-12-18 1987-11-03 Merck & Co., Inc. Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
US4731472A (en) 1986-03-03 1988-03-15 Merck & Co., Inc. (5,6-dichloro-3-oxo-9A-propyl-2,3,9,9A-tetrahydrofluoren-7-yl)alkanoic acids and alkanimidamides
US4835313A (en) 1986-03-03 1989-05-30 Merck & Co., Inc. (5,6-dichloro-3-oxo-9α-propyl-2,3,9,9α-tetrahydrofluoren-7-yl) alkanimidamides
US4675341A (en) 1986-08-13 1987-06-23 Merck & Co., Inc. [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol and its derivatives
US4797391A (en) 1986-09-24 1989-01-10 Merck & Co., Inc. ((5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides
US4731471A (en) 1986-11-03 1988-03-15 Merck & Co., Inc. (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents
US4731470A (en) 1986-11-03 1988-03-15 Merck & Co., Inc. [(5,6-dichloro-3-oxo-2,9a-alkano-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]alkanoic acids and alkanimidamides
US6251898B1 (en) 1999-08-24 2001-06-26 Questcor Pharmaceuticals, Inc. Medical use of fluorenone derivatives for treating and preventing brain and spinal injury
AU784200B2 (en) 2000-02-14 2006-02-23 Merck Sharp & Dohme Corp. Estrogen receptor modulators

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