TW200604344A - Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof - Google Patents

Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof

Info

Publication number
TW200604344A
TW200604344A TW094118590A TW94118590A TW200604344A TW 200604344 A TW200604344 A TW 200604344A TW 094118590 A TW094118590 A TW 094118590A TW 94118590 A TW94118590 A TW 94118590A TW 200604344 A TW200604344 A TW 200604344A
Authority
TW
Taiwan
Prior art keywords
mutants
enzymes
deoxy
ribose
relates
Prior art date
Application number
TW094118590A
Other languages
English (en)
Inventor
Martin Schuermann
Marcel Gerhardus Wubbolts
Daniel Mink
Michael Wolberg
Johannes Helena Michael Mommers
Stefan Martin Jennewein
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of TW200604344A publication Critical patent/TW200604344A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW094118590A 2004-06-04 2005-06-06 Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof TW200604344A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076639 2004-06-04
US57865504P 2004-06-10 2004-06-10

Publications (1)

Publication Number Publication Date
TW200604344A true TW200604344A (en) 2006-02-01

Family

ID=34928263

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094118590A TW200604344A (en) 2004-06-04 2005-06-06 Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof

Country Status (8)

Country Link
US (1) US20090209001A1 (zh)
EP (1) EP1751287A2 (zh)
JP (1) JP2008541693A (zh)
CN (1) CN1965084A (zh)
CA (1) CA2568728A1 (zh)
MX (1) MXPA06014090A (zh)
TW (1) TW200604344A (zh)
WO (1) WO2005118794A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183397B2 (en) 2007-04-03 2012-05-22 Lek Pharmaceuticals D.D. Synthesis of statins
EP2532660B1 (en) 2007-08-03 2014-09-10 Pfizer Products Inc. Process for preparing chiral compounds
WO2009092702A2 (en) 2008-01-23 2009-07-30 Lek Pharmaceuticals D.D. ((2s,4r)-4,6-dihydroxytetrahydro-2h-pyran-2-yl)methyl carboxylate and process for the production thereof
WO2011012702A1 (en) * 2009-07-30 2011-02-03 Metabolic Explorer Mutant glycerol dehydrogenase (glydh) for the production of a biochemical by fermentation
CN103403174B (zh) 2010-12-20 2017-10-27 力奇制药公司 活性药物成分及其中间物的酶促合成
EP2465936A1 (en) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of statins and intermediates thereof
CN103409402B (zh) * 2013-08-28 2015-05-27 南京博优康远生物医药科技有限公司 醛缩酶突变体
CN104017795B (zh) * 2014-05-27 2016-05-25 中国科学院天津工业生物技术研究所 一种利用醛缩酶生物合成2-脱氧稀少醛糖的方法
CN105063000B (zh) * 2015-08-28 2018-07-13 安徽丰原发酵技术工程研究有限公司 大肠杆菌2-脱氧-d-核糖-5-磷酸醛缩酶突变体及其制备方法
GB201605354D0 (en) 2016-03-30 2016-05-11 Zuvasyntha Ltd Modified enzyme
CA3025584A1 (en) 2016-06-30 2018-01-04 Ardra Bio Inc. Methods and microorganisms for producing flavors and fragrance chemicals
CN112673105A (zh) * 2018-07-09 2021-04-16 科德克希思公司 工程化脱氧核糖磷酸醛缩酶
CN111876404B (zh) * 2020-07-30 2021-12-21 浙大宁波理工学院 一种醛缩酶突变体及其编码基因和应用
CN113444712B (zh) * 2021-05-26 2022-06-21 浙江工业大学 一种L-天冬氨酸-α-脱羧酶突变体及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232416A1 (en) * 2002-03-14 2003-12-18 Chi-Huey Wong Synthesis of synthons for the manufacture of bioactive compounds
US7414119B2 (en) * 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them

Also Published As

Publication number Publication date
US20090209001A1 (en) 2009-08-20
MXPA06014090A (es) 2007-03-07
EP1751287A2 (en) 2007-02-14
JP2008541693A (ja) 2008-11-27
WO2005118794A3 (en) 2006-02-16
CN1965084A (zh) 2007-05-16
WO2005118794A2 (en) 2005-12-15
CA2568728A1 (en) 2005-12-15

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