TW200602053A - New crystalline form of 8-cyano-1-cyclopropyl-7-(1s, 6s-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid - Google Patents

New crystalline form of 8-cyano-1-cyclopropyl-7-(1s, 6s-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid

Info

Publication number
TW200602053A
TW200602053A TW094110161A TW94110161A TW200602053A TW 200602053 A TW200602053 A TW 200602053A TW 094110161 A TW094110161 A TW 094110161A TW 94110161 A TW94110161 A TW 94110161A TW 200602053 A TW200602053 A TW 200602053A
Authority
TW
Taiwan
Prior art keywords
nonan
diazabicyclo
cyclopropyl
dihydro
oxo
Prior art date
Application number
TW094110161A
Other languages
English (en)
Other versions
TWI350755B (en
Inventor
Hubert Rast
Iris Heep
Alfons Grunenberg
Werner Hallenbach
Jordi Benet-Buchholz
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of TW200602053A publication Critical patent/TW200602053A/zh
Application granted granted Critical
Publication of TWI350755B publication Critical patent/TWI350755B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
TW094110161A 2004-04-01 2005-03-31 New crystalline form of 8-cyano-1-cyclopropyl-7-(1s,6s-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid TWI350755B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004015981A DE102004015981A1 (de) 2004-04-01 2004-04-01 Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure

Publications (2)

Publication Number Publication Date
TW200602053A true TW200602053A (en) 2006-01-16
TWI350755B TWI350755B (en) 2011-10-21

Family

ID=34962324

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094110161A TWI350755B (en) 2004-04-01 2005-03-31 New crystalline form of 8-cyano-1-cyclopropyl-7-(1s,6s-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Country Status (32)

Country Link
US (1) US7977484B2 (zh)
EP (1) EP1737859B1 (zh)
JP (1) JP5190259B2 (zh)
KR (1) KR101217678B1 (zh)
CN (1) CN100591681C (zh)
AR (2) AR048099A1 (zh)
AT (1) ATE450536T1 (zh)
AU (1) AU2005231918B2 (zh)
BR (1) BRPI0509529B8 (zh)
CA (1) CA2561635C (zh)
CY (2) CY1109762T1 (zh)
DE (3) DE102004015981A1 (zh)
DK (1) DK1737859T3 (zh)
ES (1) ES2335899T3 (zh)
GT (1) GT200500043A (zh)
HK (1) HK1104537A1 (zh)
HR (1) HRP20100097T1 (zh)
IL (1) IL178353A (zh)
MY (1) MY140998A (zh)
NO (1) NO337279B1 (zh)
NZ (1) NZ550226A (zh)
PE (1) PE20060170A1 (zh)
PL (1) PL1737859T3 (zh)
PT (1) PT1737859E (zh)
RU (1) RU2383543C2 (zh)
SI (1) SI1737859T1 (zh)
SV (1) SV2006002070A (zh)
TW (1) TWI350755B (zh)
UA (1) UA84329C2 (zh)
UY (1) UY28828A1 (zh)
WO (1) WO2005097789A1 (zh)
ZA (1) ZA200608072B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
CN110248643B (zh) 2017-02-13 2023-11-24 拜耳动物保健有限责任公司 含普拉沙星的液体组合物
CN115710267A (zh) * 2022-11-30 2023-02-24 天津大学 一种普拉沙星水合物晶体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE228130T1 (de) * 1996-02-23 2002-12-15 Bayer Ag Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0)-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3- hinolincarbonsäuren und ihre derivate
DE19854357A1 (de) 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs

Also Published As

Publication number Publication date
DE502005008620D1 (de) 2010-01-14
KR101217678B1 (ko) 2013-01-02
RU2383543C2 (ru) 2010-03-10
IL178353A (en) 2011-08-31
AU2005231918B2 (en) 2011-05-12
ZA200608072B (en) 2008-01-08
DE122011100055I1 (de) 2012-03-15
WO2005097789A1 (de) 2005-10-20
CN1938304A (zh) 2007-03-28
CY2011018I1 (el) 2016-12-14
NO337279B1 (no) 2016-02-29
IL178353A0 (en) 2007-02-11
SI1737859T1 (sl) 2010-03-31
AR105177A2 (es) 2017-09-13
CN100591681C (zh) 2010-02-24
PT1737859E (pt) 2010-02-03
JP2007530614A (ja) 2007-11-01
EP1737859B1 (de) 2009-12-02
EP1737859A1 (de) 2007-01-03
BRPI0509529B1 (pt) 2019-05-21
TWI350755B (en) 2011-10-21
MY140998A (en) 2010-02-12
HK1104537A1 (en) 2008-01-18
BRPI0509529A (pt) 2007-09-18
RU2006138362A (ru) 2008-05-10
KR20070014157A (ko) 2007-01-31
JP5190259B2 (ja) 2013-04-24
SV2006002070A (es) 2006-03-15
ATE450536T1 (de) 2009-12-15
CY1109762T1 (el) 2014-09-10
PL1737859T3 (pl) 2010-04-30
BRPI0509529B8 (pt) 2021-05-25
NO20064988L (no) 2006-10-31
ES2335899T3 (es) 2010-04-06
AR048099A1 (es) 2006-03-29
UY28828A1 (es) 2005-11-30
AU2005231918A1 (en) 2005-10-20
CA2561635A1 (en) 2005-10-20
GT200500043A (es) 2006-02-17
US20080125458A1 (en) 2008-05-29
DK1737859T3 (da) 2010-04-06
US7977484B2 (en) 2011-07-12
HRP20100097T1 (hr) 2010-04-30
NZ550226A (en) 2009-11-27
DE102004015981A1 (de) 2005-10-20
UA84329C2 (en) 2008-10-10
PE20060170A1 (es) 2006-04-13
CA2561635C (en) 2012-10-16

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