WO2006134491A3 - New crystalline form of moxifloxacin hydrochloride and process for its preparation - Google Patents

New crystalline form of moxifloxacin hydrochloride and process for its preparation Download PDF

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Publication number
WO2006134491A3
WO2006134491A3 PCT/IB2006/001721 IB2006001721W WO2006134491A3 WO 2006134491 A3 WO2006134491 A3 WO 2006134491A3 IB 2006001721 W IB2006001721 W IB 2006001721W WO 2006134491 A3 WO2006134491 A3 WO 2006134491A3
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WO
WIPO (PCT)
Prior art keywords
crystalline form
new crystalline
preparation
moxifloxacin hydrochloride
relates
Prior art date
Application number
PCT/IB2006/001721
Other languages
French (fr)
Other versions
WO2006134491A2 (en
Inventor
Ramesh Dandala
Jayati Mitra
Arun Kumar Gupta
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Ltd
Ramesh Dandala
Jayati Mitra
Arun Kumar Gupta
Sivakumaran Meenakshisunderam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd, Ramesh Dandala, Jayati Mitra, Arun Kumar Gupta, Sivakumaran Meenakshisunderam filed Critical Aurobindo Pharma Ltd
Publication of WO2006134491A2 publication Critical patent/WO2006134491A2/en
Publication of WO2006134491A3 publication Critical patent/WO2006134491A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention relates to a new crystalline form of 1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride of the Formula I with a moisture content below 2 % w/w (Form A). The present invention also relates to a process of preparing the new crystalline form.
PCT/IB2006/001721 2005-06-14 2006-06-01 New crystalline form of moxifloxacin hydrochloride and process for its preparation WO2006134491A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN721/CHE/2005 2005-06-14
IN721CH2005 2005-06-14

Publications (2)

Publication Number Publication Date
WO2006134491A2 WO2006134491A2 (en) 2006-12-21
WO2006134491A3 true WO2006134491A3 (en) 2007-05-10

Family

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Family Applications (1)

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PCT/IB2006/001721 WO2006134491A2 (en) 2005-06-14 2006-06-01 New crystalline form of moxifloxacin hydrochloride and process for its preparation

Country Status (1)

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WO (1) WO2006134491A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2303768B1 (en) * 2006-09-08 2009-06-05 Quimica Sintetica, S.A. NEW CRYSTAL FORM OF MOXIFLOXACINO CHLORHYDRATE.
JP2010509305A (en) * 2006-11-13 2010-03-25 シプラ・リミテッド Method for the synthesis of moxifloxacin hydrochloride
ES2316270B1 (en) * 2007-02-07 2010-02-09 Quimica Sintetica, S.A. NEW CRYSTAL FORM OF MOXIFLOXACINO CHLORHYDRATE ANHYDRA FORM IV.
EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
IT1393337B1 (en) 2009-03-06 2012-04-20 Italiana Sint Spa SUMMARY OF (4AS, 7AS) -OTTAIDRO-1H-PIRROLO [3,4-B] PYRIDINE
ITTO20110705A1 (en) 2011-07-29 2013-01-30 Italiana Sint Spa PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINE CHLORIDRATE AND RELATED INTERMEDIATES
CN103183672A (en) * 2011-12-29 2013-07-03 天津康鸿医药科技发展有限公司 Novel moxifloxacin hydrochloride crystal, and preparation method and application thereof
CN102924449B (en) * 2012-10-30 2015-08-12 重庆福安药业集团庆余堂制药有限公司 Moxifloxacin hydrochloride H crystal form and preparation method thereof and pharmaceutical composition
CN103869033B (en) * 2012-12-14 2016-10-05 南京长澳医药科技有限公司 A kind of liquid chromatography for separating and determining moxifloxacin hydrochloride and the method for impurity thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751948A1 (en) * 1997-11-24 1999-05-27 Bayer Ag Rapid preparation of 8-alkoxy-quinolone-carboxylic acid derivative antibacterial agent, e.g. gatifloxacin, in high purity
WO2004091619A1 (en) * 2003-04-09 2004-10-28 Dr. Reddy's Laboratories Limited A crystalline form iii of anhydrous moxifloxacin hydrochloride and a process for preparation thereof
WO2005012285A1 (en) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751948A1 (en) * 1997-11-24 1999-05-27 Bayer Ag Rapid preparation of 8-alkoxy-quinolone-carboxylic acid derivative antibacterial agent, e.g. gatifloxacin, in high purity
WO2004091619A1 (en) * 2003-04-09 2004-10-28 Dr. Reddy's Laboratories Limited A crystalline form iii of anhydrous moxifloxacin hydrochloride and a process for preparation thereof
WO2005012285A1 (en) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof

Also Published As

Publication number Publication date
WO2006134491A2 (en) 2006-12-21

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