WO2009139002A3 - An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof - Google Patents

An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof Download PDF

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Publication number
WO2009139002A3
WO2009139002A3 PCT/IN2009/000278 IN2009000278W WO2009139002A3 WO 2009139002 A3 WO2009139002 A3 WO 2009139002A3 IN 2009000278 W IN2009000278 W IN 2009000278W WO 2009139002 A3 WO2009139002 A3 WO 2009139002A3
Authority
WO
WIPO (PCT)
Prior art keywords
solifenacin
preparation
improved process
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IN2009/000278
Other languages
French (fr)
Other versions
WO2009139002A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Mummadi Venkatesh
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2009139002A2 publication Critical patent/WO2009139002A2/en
Publication of WO2009139002A3 publication Critical patent/WO2009139002A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Abstract

The present invention relates to an improved process for the preparation of solifenacin compound of formula (1) and its succinate salt compound of formula (1a), comprising the condensation of (R)-3- quinuclidinol with (S)-ethyl- 1 -phenyl- 1,2,3,4-tetrahydro-2-isoquinoline carboxylate in presence of a suitable hydroxide base in a suitable solvent.
PCT/IN2009/000278 2008-05-12 2009-05-11 An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof WO2009139002A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1161CH2008 2008-05-12
IN1161/CHE/2008 2008-05-12

Publications (2)

Publication Number Publication Date
WO2009139002A2 WO2009139002A2 (en) 2009-11-19
WO2009139002A3 true WO2009139002A3 (en) 2010-10-28

Family

ID=41319138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000278 WO2009139002A2 (en) 2008-05-12 2009-05-11 An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof

Country Status (1)

Country Link
WO (1) WO2009139002A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011048607A1 (en) * 2009-09-25 2011-04-28 Cadila Healthcare Limited Processes for the preparation of solifenacin or a salt thereof
WO2012004264A1 (en) 2010-07-05 2012-01-12 Ragactives, S.L.U. Solifenacin salts
CA2817336A1 (en) 2010-11-11 2012-05-18 Hexal Ag Crystalline solifenacin succinate
CN102887894A (en) * 2011-07-18 2013-01-23 天津市医药集团技术发展有限公司 Crystal form of solifenacin succinate and preparation method thereof
CN104768540A (en) 2012-09-05 2015-07-08 才思制药公司 Anticholinergic neuroprotective composition and methods
CN103896938B (en) * 2014-04-24 2016-02-24 重庆科瑞制药(集团)有限公司 A kind of preparation method of succsinic acid YM-905

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008011462A2 (en) * 2006-07-19 2008-01-24 Dr. Reddy's Laboratories Ltd. Process for preparing solifenacin and its salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008011462A2 (en) * 2006-07-19 2008-01-24 Dr. Reddy's Laboratories Ltd. Process for preparing solifenacin and its salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAITO R ET AL.: "Synthesis and antimuscarinic properties of quinuclidin-3-yl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.", J MED CHEM., vol. 48, no. 21, 20 October 2005 (2005-10-20), pages 6597 - 606 *

Also Published As

Publication number Publication date
WO2009139002A2 (en) 2009-11-19

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