WO2009125425A3 - Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane - Google Patents

Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane Download PDF

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Publication number
WO2009125425A3
WO2009125425A3 PCT/IN2009/000087 IN2009000087W WO2009125425A3 WO 2009125425 A3 WO2009125425 A3 WO 2009125425A3 IN 2009000087 W IN2009000087 W IN 2009000087W WO 2009125425 A3 WO2009125425 A3 WO 2009125425A3
Authority
WO
WIPO (PCT)
Prior art keywords
nonane
diazabicyclo
preparation
improved process
directed
Prior art date
Application number
PCT/IN2009/000087
Other languages
French (fr)
Other versions
WO2009125425A2 (en
Inventor
Arul Ramakrishnan
Sanjay Bhawsar
Venugoplarao Narayana
Original Assignee
Neuland Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuland Laboratories Ltd filed Critical Neuland Laboratories Ltd
Publication of WO2009125425A2 publication Critical patent/WO2009125425A2/en
Publication of WO2009125425A3 publication Critical patent/WO2009125425A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention is directed to an improved industrially viable, cost effective process for manufacturing (S,S)-2,8-Diazabicyclo[4.3.0]nonane in a substantially pure form and consequent conversion to Moxifloxacin hydrochloride monohydrate.
PCT/IN2009/000087 2008-02-08 2009-02-09 Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane WO2009125425A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN329CH2008 2008-02-08
IN329/CHE/2008 2008-02-08

Publications (2)

Publication Number Publication Date
WO2009125425A2 WO2009125425A2 (en) 2009-10-15
WO2009125425A3 true WO2009125425A3 (en) 2009-12-03

Family

ID=41162343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000087 WO2009125425A2 (en) 2008-02-08 2009-02-09 Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane

Country Status (1)

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WO (1) WO2009125425A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102432515B (en) * 2010-11-17 2013-08-14 江苏恒祥化工有限责任公司 Preparation technology for N-ethyl pyrrolidine
CN103044418B (en) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 Asymmetric synthesis method, relevant raw materials and preparation method of (S,S)-2,8-diazabicyclo[4,3,0] nonane
CN104016981B (en) * 2014-06-23 2016-03-23 南京正大天晴制药有限公司 A kind of Moxifloxacin hydrochloride analog and preparation method thereof
CN110317201B (en) * 2019-07-31 2022-03-01 武汉理工大学 Asymmetric synthesis method of (S, S) -2, 8-diazabicyclo [4,3,0] nonane
CN110694617B (en) * 2019-10-13 2022-05-03 西安凯立新材料股份有限公司 Preparation method of catalyst for synthesis of moxifloxacin
CN115010709A (en) * 2022-07-06 2022-09-06 厦门大学 Synthesis method of pyrrolo [3,4-b ] pyridine-5, 7-dione

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821039A1 (en) * 1998-05-11 1999-11-18 Bayer Ag Production of (S,S)-8-benzyl-2,8-diazabicyclo(4.3.0)nonane useful as intermediate for antibiotic moxifloxacin
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821039A1 (en) * 1998-05-11 1999-11-18 Bayer Ag Production of (S,S)-8-benzyl-2,8-diazabicyclo(4.3.0)nonane useful as intermediate for antibiotic moxifloxacin
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT LIU, MINGLIANG ET AL.: "Synthesis of moxifloxacin", Database accession no. 144:71432 *
ZHONGGUO YIYAO GONGYE ZAZHI, vol. 35, no. 3, 2004, pages 129 - 131 *

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