TW200526630A - Novel pyridine derivatives - Google Patents

Novel pyridine derivatives Download PDF

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Publication number
TW200526630A
TW200526630A TW093129149A TW93129149A TW200526630A TW 200526630 A TW200526630 A TW 200526630A TW 093129149 A TW093129149 A TW 093129149A TW 93129149 A TW93129149 A TW 93129149A TW 200526630 A TW200526630 A TW 200526630A
Authority
TW
Taiwan
Prior art keywords
ethyl
ratio
dimethyl
ureido
methyl
Prior art date
Application number
TW093129149A
Other languages
English (en)
Chinese (zh)
Inventor
Boris Mathys
Claus Muller
Michael Scherz
Thomas Weller
Martine Clozel
Jorg Velker
Daniel Bur
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of TW200526630A publication Critical patent/TW200526630A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
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TW093129149A 2003-09-26 2004-09-24 Novel pyridine derivatives TW200526630A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0310746 2003-09-26

Publications (1)

Publication Number Publication Date
TW200526630A true TW200526630A (en) 2005-08-16

Family

ID=34384524

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093129149A TW200526630A (en) 2003-09-26 2004-09-24 Novel pyridine derivatives

Country Status (18)

Country Link
US (1) US7750161B2 (enExample)
EP (1) EP1670470B1 (enExample)
JP (1) JP4851328B2 (enExample)
KR (1) KR20070014108A (enExample)
CN (1) CN1856305B (enExample)
AR (1) AR045949A1 (enExample)
AT (1) ATE427748T1 (enExample)
AU (1) AU2004275488A1 (enExample)
BR (1) BRPI0414777A (enExample)
CA (1) CA2540196C (enExample)
DE (1) DE602004020486D1 (enExample)
IL (1) IL174497A0 (enExample)
MX (1) MXPA06003264A (enExample)
NO (1) NO20061395L (enExample)
RU (1) RU2006113948A (enExample)
TW (1) TW200526630A (enExample)
WO (1) WO2005030209A1 (enExample)
ZA (1) ZA200602442B (enExample)

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KR20070014108A (ko) 2007-01-31
CA2540196A1 (en) 2005-04-07
RU2006113948A (ru) 2007-11-10
EP1670470B1 (en) 2009-04-08
ZA200602442B (en) 2007-09-26
IL174497A0 (en) 2006-08-01
WO2005030209A1 (en) 2005-04-07
WO2005030209A8 (en) 2006-05-11
MXPA06003264A (es) 2006-06-08
CA2540196C (en) 2012-03-20
BRPI0414777A (pt) 2006-11-21
US20070043081A1 (en) 2007-02-22
US7750161B2 (en) 2010-07-06
JP4851328B2 (ja) 2012-01-11
CN1856305B (zh) 2010-04-28
AR045949A1 (es) 2005-11-16
NO20061395L (no) 2006-06-22
DE602004020486D1 (de) 2009-05-20
CN1856305A (zh) 2006-11-01
AU2004275488A1 (en) 2005-04-07
EP1670470A1 (en) 2006-06-21
JP2007506692A (ja) 2007-03-22
ATE427748T1 (de) 2009-04-15

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