AR041885A1 - Compuesto de sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion - Google Patents
Compuesto de sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicionInfo
- Publication number
- AR041885A1 AR041885A1 ARP030104038A ARP030104038A AR041885A1 AR 041885 A1 AR041885 A1 AR 041885A1 AR P030104038 A ARP030104038 A AR P030104038A AR P030104038 A ARP030104038 A AR P030104038A AR 041885 A1 AR041885 A1 AR 041885A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- composition
- pharmaceutical composition
- sulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de sulfonamida que tiene la fórmula (1), en la cual: Ar es fenilo sustituido o sin sustituir con uno o dos de los siguientes: halógenos, CN, S(alquilo C1-6), CF3, OCF3, SCF3, alquilo C1-6, alcoxi C1-6, CO2(alquilo C1-6) o NO2; Y es O o S; Z es hidrógeno, halógeno o alquilo C1-6; R2 es hidrógeno, halógeno, CN o alquilo C1-4; R1 es hidrógeno o alquilo C1-6; o una sal farmacéuticamente aceptable del mismo. Composición farmacéutica que comprende un compuesto de fórmula (1) y un vehículo o excipiente farmacéuticamente aceptable. La presente se refiere a sulfonamidas, composiciones farmacéuticas que las contienen y su uso para tratar estados asociados con un desequilibrio de urotensina-II antagonizando el receptor de uretensina-II. Dichos estados pueden ser fallo cardiaco congestivo, apoplejía, enfermedad cardiaca isquémica, angina, isquemia de miocardio, arritmia cardiaca, hipertensión esencial y pulmonar, enfermedad renal, fallo renal agudo y crónico, entre otros.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42416202P | 2002-11-06 | 2002-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR041885A1 true AR041885A1 (es) | 2005-06-01 |
Family
ID=32312762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104038A AR041885A1 (es) | 2002-11-06 | 2003-11-04 | Compuesto de sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR041885A1 (es) |
AU (2) | AU2003291264A1 (es) |
TW (1) | TW200418831A (es) |
WO (2) | WO2004043463A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004275488A1 (en) | 2003-09-26 | 2005-04-07 | Actelion Pharmaceuticals Ltd | Pyridine derivatives and use thereof as urotensin II antagonists |
CN101039930B (zh) | 2004-10-12 | 2010-08-11 | 埃科特莱茵药品有限公司 | 作为结晶硫酸盐的1-[2-(4-甲苯基-4-羟基-哌啶-1-基)-乙基]-3-(2-甲基-喹啉-4-基)-脲 |
CL2007002097A1 (es) | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
EP2590957B1 (en) | 2010-07-09 | 2014-11-12 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3378565A (en) * | 1966-04-25 | 1968-04-16 | Dow Chemical Co | Sulfamoylpyridyl phosphorothioates and intermediates therefor |
US5338739A (en) * | 1994-03-10 | 1994-08-16 | Hoechst-Roussel Pharmaceuticals Inc. | (Pyrrolidinyl)phenyl carbamates, compositions and use |
US5869428A (en) * | 1995-03-13 | 1999-02-09 | Ishihara Sangyo Kaisha Ltd. | Pyridonesulfonylurea compounds, process for their production and herbicides containing them |
-
2003
- 2003-11-04 TW TW092130759A patent/TW200418831A/zh unknown
- 2003-11-04 AR ARP030104038A patent/AR041885A1/es unknown
- 2003-11-06 AU AU2003291264A patent/AU2003291264A1/en not_active Abandoned
- 2003-11-06 WO PCT/US2003/035370 patent/WO2004043463A2/en not_active Application Discontinuation
- 2003-11-06 AU AU2003287529A patent/AU2003287529A1/en not_active Abandoned
- 2003-11-06 WO PCT/US2003/035369 patent/WO2004043948A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2003291264A1 (en) | 2004-06-03 |
AU2003287529A1 (en) | 2004-06-03 |
WO2004043463A3 (en) | 2004-06-17 |
WO2004043463A2 (en) | 2004-05-27 |
WO2004043948A1 (en) | 2004-05-27 |
TW200418831A (en) | 2004-10-01 |
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Legal Events
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FB | Suspension of granting procedure |