TW200524911A - N-substituted pyrazolyl-amidyl-benzimidazolyl C-KIT inhibitors - Google Patents

N-substituted pyrazolyl-amidyl-benzimidazolyl C-KIT inhibitors Download PDF

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Publication number
TW200524911A
TW200524911A TW093125240A TW93125240A TW200524911A TW 200524911 A TW200524911 A TW 200524911A TW 093125240 A TW093125240 A TW 093125240A TW 93125240 A TW93125240 A TW 93125240A TW 200524911 A TW200524911 A TW 200524911A
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TW
Taiwan
Prior art keywords
alkyl
cancer
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
TW093125240A
Other languages
English (en)
Chinese (zh)
Inventor
Joshua Bolger
Arlindo L Castelhano
Andrew Phillip Crew
Radoslaw Laufer
An-Hu Li
Smith Colin Peter Sambrook
Yingchuan Sun
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of TW200524911A publication Critical patent/TW200524911A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW093125240A 2003-08-21 2004-08-20 N-substituted pyrazolyl-amidyl-benzimidazolyl C-KIT inhibitors TW200524911A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21

Publications (1)

Publication Number Publication Date
TW200524911A true TW200524911A (en) 2005-08-01

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093125240A TW200524911A (en) 2003-08-21 2004-08-20 N-substituted pyrazolyl-amidyl-benzimidazolyl C-KIT inhibitors

Country Status (19)

Country Link
EP (1) EP1664032B1 (enExample)
JP (1) JP4795237B2 (enExample)
KR (1) KR20060115346A (enExample)
CN (1) CN1839130A (enExample)
AP (1) AP2006003553A0 (enExample)
AR (1) AR045389A1 (enExample)
AT (1) ATE413395T1 (enExample)
AU (1) AU2004268948A1 (enExample)
BR (1) BRPI0413785A (enExample)
CA (1) CA2536151A1 (enExample)
DE (1) DE602004017623D1 (enExample)
IL (1) IL173616A0 (enExample)
IS (1) IS8320A (enExample)
MX (1) MXPA06002017A (enExample)
NO (1) NO20060665L (enExample)
RU (1) RU2006108791A (enExample)
TW (1) TW200524911A (enExample)
UA (1) UA84712C2 (enExample)
WO (1) WO2005021537A1 (enExample)

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US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
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CN110072528B (zh) 2017-02-08 2022-04-26 卫材R&D管理有限公司 治疗肿瘤的药物组合物
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Also Published As

Publication number Publication date
AP2006003553A0 (en) 2006-04-30
IL173616A0 (en) 2006-07-05
RU2006108791A (ru) 2006-07-27
UA84712C2 (en) 2008-11-25
BRPI0413785A (pt) 2006-11-07
AR045389A1 (es) 2005-10-26
ATE413395T1 (de) 2008-11-15
JP2007502820A (ja) 2007-02-15
JP4795237B2 (ja) 2011-10-19
CA2536151A1 (en) 2005-03-10
EP1664032B1 (en) 2008-11-05
DE602004017623D1 (de) 2008-12-18
CN1839130A (zh) 2006-09-27
EP1664032A1 (en) 2006-06-07
IS8320A (is) 2006-02-21
AU2004268948A1 (en) 2005-03-10
NO20060665L (no) 2006-05-16
MXPA06002017A (es) 2006-05-31
WO2005021537A1 (en) 2005-03-10
KR20060115346A (ko) 2006-11-08

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