UA84712C2 - N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors - Google Patents

N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Info

Publication number
UA84712C2
UA84712C2 UAA200602943A UAA200602943A UA84712C2 UA 84712 C2 UA84712 C2 UA 84712C2 UA A200602943 A UAA200602943 A UA A200602943A UA A200602943 A UAA200602943 A UA A200602943A UA 84712 C2 UA84712 C2 UA 84712C2
Authority
UA
Ukraine
Prior art keywords
amidyl
benzimidazolyl
substituted pyrazolyl
kit inhibitors
inhibitors
Prior art date
Application number
UAA200602943A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джошуа Болджер
Арлиндо Л. Кастелано
Эндрю Филип Крю
Радослав Лауфер
Ань-Ху Ли
Смит Колин Питер Сембрук
Инчуань Суй
Original Assignee
Оси Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оси Фармасьютикалз, Инк. filed Critical Оси Фармасьютикалз, Инк.
Publication of UA84712C2 publication Critical patent/UA84712C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения, представленные формулой (І), или их фармацевтически приемлемые соли или N-оксиды могут применяться для лечения рака.
UAA200602943A 2003-08-21 2004-08-16 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors UA84712C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21

Publications (1)

Publication Number Publication Date
UA84712C2 true UA84712C2 (en) 2008-11-25

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602943A UA84712C2 (en) 2003-08-21 2004-08-16 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Country Status (19)

Country Link
EP (1) EP1664032B1 (ru)
JP (1) JP4795237B2 (ru)
KR (1) KR20060115346A (ru)
CN (1) CN1839130A (ru)
AP (1) AP2006003553A0 (ru)
AR (1) AR045389A1 (ru)
AT (1) ATE413395T1 (ru)
AU (1) AU2004268948A1 (ru)
BR (1) BRPI0413785A (ru)
CA (1) CA2536151A1 (ru)
DE (1) DE602004017623D1 (ru)
IL (1) IL173616A0 (ru)
IS (1) IS8320A (ru)
MX (1) MXPA06002017A (ru)
NO (1) NO20060665L (ru)
RU (1) RU2006108791A (ru)
TW (1) TW200524911A (ru)
UA (1) UA84712C2 (ru)
WO (1) WO2005021537A1 (ru)

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KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
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Also Published As

Publication number Publication date
KR20060115346A (ko) 2006-11-08
AP2006003553A0 (en) 2006-04-30
IL173616A0 (en) 2006-07-05
CN1839130A (zh) 2006-09-27
AR045389A1 (es) 2005-10-26
BRPI0413785A (pt) 2006-11-07
JP4795237B2 (ja) 2011-10-19
IS8320A (is) 2006-02-21
TW200524911A (en) 2005-08-01
MXPA06002017A (es) 2006-05-31
RU2006108791A (ru) 2006-07-27
NO20060665L (no) 2006-05-16
JP2007502820A (ja) 2007-02-15
AU2004268948A1 (en) 2005-03-10
EP1664032B1 (en) 2008-11-05
ATE413395T1 (de) 2008-11-15
DE602004017623D1 (de) 2008-12-18
WO2005021537A1 (en) 2005-03-10
CA2536151A1 (en) 2005-03-10
EP1664032A1 (en) 2006-06-07

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