IL173616A0 - N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors - Google Patents

N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Info

Publication number
IL173616A0
IL173616A0 IL173616A IL17361606A IL173616A0 IL 173616 A0 IL173616 A0 IL 173616A0 IL 173616 A IL173616 A IL 173616A IL 17361606 A IL17361606 A IL 17361606A IL 173616 A0 IL173616 A0 IL 173616A0
Authority
IL
Israel
Prior art keywords
amidyl
benzimidazolyl
substituted pyrazolyl
kit inhibitors
inhibitors
Prior art date
Application number
IL173616A
Other languages
English (en)
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of IL173616A0 publication Critical patent/IL173616A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL173616A 2003-08-21 2006-02-08 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors IL173616A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21
PCT/US2004/026481 WO2005021537A1 (en) 2003-08-21 2004-08-16 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Publications (1)

Publication Number Publication Date
IL173616A0 true IL173616A0 (en) 2006-07-05

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
IL173616A IL173616A0 (en) 2003-08-21 2006-02-08 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Country Status (19)

Country Link
EP (1) EP1664032B1 (enExample)
JP (1) JP4795237B2 (enExample)
KR (1) KR20060115346A (enExample)
CN (1) CN1839130A (enExample)
AP (1) AP2006003553A0 (enExample)
AR (1) AR045389A1 (enExample)
AT (1) ATE413395T1 (enExample)
AU (1) AU2004268948A1 (enExample)
BR (1) BRPI0413785A (enExample)
CA (1) CA2536151A1 (enExample)
DE (1) DE602004017623D1 (enExample)
IL (1) IL173616A0 (enExample)
IS (1) IS8320A (enExample)
MX (1) MXPA06002017A (enExample)
NO (1) NO20060665L (enExample)
RU (1) RU2006108791A (enExample)
TW (1) TW200524911A (enExample)
UA (1) UA84712C2 (enExample)
WO (1) WO2005021537A1 (enExample)

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AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
NZ714049A (en) 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
TW201534597A (zh) 2013-06-20 2015-09-16 Ab Science 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
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Also Published As

Publication number Publication date
ATE413395T1 (de) 2008-11-15
JP4795237B2 (ja) 2011-10-19
BRPI0413785A (pt) 2006-11-07
CN1839130A (zh) 2006-09-27
NO20060665L (no) 2006-05-16
AP2006003553A0 (en) 2006-04-30
MXPA06002017A (es) 2006-05-31
KR20060115346A (ko) 2006-11-08
EP1664032B1 (en) 2008-11-05
TW200524911A (en) 2005-08-01
WO2005021537A1 (en) 2005-03-10
JP2007502820A (ja) 2007-02-15
IS8320A (is) 2006-02-21
DE602004017623D1 (de) 2008-12-18
AR045389A1 (es) 2005-10-26
AU2004268948A1 (en) 2005-03-10
UA84712C2 (en) 2008-11-25
EP1664032A1 (en) 2006-06-07
CA2536151A1 (en) 2005-03-10
RU2006108791A (ru) 2006-07-27

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