TW200408399A - Compositions and methods for treating epithelial and retinal tissue diseases - Google Patents
Compositions and methods for treating epithelial and retinal tissue diseases Download PDFInfo
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- TW200408399A TW200408399A TW092104241A TW92104241A TW200408399A TW 200408399 A TW200408399 A TW 200408399A TW 092104241 A TW092104241 A TW 092104241A TW 92104241 A TW92104241 A TW 92104241A TW 200408399 A TW200408399 A TW 200408399A
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
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Applications Claiming Priority (1)
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|---|---|---|---|
| US10/082,998 US7115585B2 (en) | 2000-08-21 | 2002-02-27 | Compositions for treating epithelial and retinal tissue diseases |
Publications (1)
| Publication Number | Publication Date |
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| TW200408399A true TW200408399A (en) | 2004-06-01 |
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Family Applications (1)
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| EP (2) | EP1545555A4 (OSRAM) |
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| US7435724B2 (en) * | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| WO2006071186A1 (en) * | 2004-12-27 | 2006-07-06 | Astrazeneca Ab | Use of gabab receptor agonists |
| EP1863826A1 (en) * | 2005-03-30 | 2007-12-12 | Inspire Pharmaceuticals, Inc. | Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles |
| KR100870104B1 (ko) * | 2005-11-28 | 2008-11-26 | 주식회사 머젠스 | 안구건조증 치료 및 예방용 조성물 |
| EP2123285A1 (en) * | 2008-05-21 | 2009-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleosidic phosphoantigens for use in VGAMMA9DELTA2 T cell-mediated therapy |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| EP2646449B1 (en) * | 2010-12-01 | 2015-08-19 | Bar-Ilan University | Uridine di- or tri-phosphate derivatives and uses thereof |
| CN103429605B (zh) * | 2011-01-26 | 2017-11-07 | 北京康倍得医药技术开发有限公司 | 呋喃核糖基嘌呤类化合物及其制备方法和应用 |
| WO2014060941A2 (en) * | 2012-10-17 | 2014-04-24 | Mahesh Kandula | Compositions and methods of neuroprotective agents for the treatment of neurological and neurodegenerative diseases |
| KR102622656B1 (ko) | 2016-02-18 | 2024-01-10 | 인버사, 인크. | 5'-아데노신 디포스페이트 리보오스 (adpr)의 사용 방법 |
| JP2020519585A (ja) * | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | 医学療法のための延長放出マイクロ粒子及びその懸濁液 |
| CA3091027A1 (en) | 2018-02-02 | 2019-08-08 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
| US10946034B2 (en) | 2018-03-27 | 2021-03-16 | Invirsa, Inc. | Methods for the use of 5′-adenosine diphosphate ribose (ADPR) |
| EP3849992A4 (en) | 2018-09-11 | 2022-06-29 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
| US11530234B2 (en) | 2018-09-11 | 2022-12-20 | Risen (Suzhou) Pharma Tech Co., Ltd. | CD73 inhibitors and pharmaceutical uses thereof |
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| US3321462A (en) * | 1963-07-15 | 1967-05-23 | Syntex Corp | Process for the preparation of nucleoside polyphosphates |
| US3324110A (en) * | 1965-02-05 | 1967-06-06 | Schering Corp | Method of phosphorylation and novel intermediates produced thereby |
| JPS509872B1 (OSRAM) * | 1969-12-22 | 1975-04-16 | ||
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| JPS5427582A (en) * | 1977-08-02 | 1979-03-01 | Mitsubishi Chem Ind Ltd | Preparation of dinucleoside triphosphate |
| US4386078A (en) * | 1980-03-03 | 1983-05-31 | The Ohio State University Research Foundation | Therapeutic agents for preventing phospholipid degradation and free fatty acid proliferation |
| US4710566A (en) * | 1984-12-27 | 1987-12-01 | Yale University | Purification of the messenger RNA cap-binding protein |
| GB8529684D0 (en) * | 1985-12-02 | 1986-01-08 | Medical Res Council | Photo-labile protecting agents |
| JPS62265299A (ja) * | 1985-12-18 | 1987-11-18 | Senjiyu Seiyaku Kk | α―トコフェロールとウリジンとのリン酸ジエステル,そのハロゲン置換体もしくはこれらの塩およびそれらの製造法 |
| IL86423A0 (en) * | 1987-05-19 | 1988-11-15 | Baylor College Medicine | Pharmaceutical compositions for the treatment of alzheimer's disease |
| DK0508687T3 (da) | 1991-04-06 | 1996-02-05 | Astra Pharma Prod | ATP-analoger |
| US5654285A (en) * | 1991-04-06 | 1997-08-05 | Astra Pharmaceuticals Limited | ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| KR100315612B1 (ko) | 1993-02-10 | 2002-06-20 | 추후제출 | N-알킬-2-치환아데노신트리포스페이트동족체 |
| US5444541A (en) * | 1994-02-16 | 1995-08-22 | Eastern Washington University | Methods for photoacoustically analyzing chemicals and chemical reactions using photoactive particle-emitting compounds |
| US5536822A (en) * | 1994-03-09 | 1996-07-16 | University Of Virginia Alumni Patents Foundation | γ-phosphate linked adenosine 5' triphosphate sepharose |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5747496A (en) | 1995-07-11 | 1998-05-05 | Astra Pharmaceuticals Limited | Inhibitors of platelet aggregation |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| WO1997021452A2 (en) * | 1995-12-14 | 1997-06-19 | Advanced Magnetics, Inc. | Macromolecular prodrugs of nucleotide analogs |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US6319908B1 (en) * | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| CA2241687A1 (en) * | 1996-10-30 | 1998-05-07 | Kenneth A. Jacobson | P2y receptor antagonists |
| AU5501598A (en) | 1996-12-20 | 1998-07-17 | Astra Pharmaceuticals Limited | Triazolo{4,5-(d)}pyrimidinyl derivatives and their use as medicaments |
| DE69834392T2 (de) * | 1997-02-06 | 2007-02-08 | Inspire Pharmaceuticals, Inc. | Dinukleotide und ihre verwendungen |
| SE9701219D0 (sv) * | 1997-04-04 | 1997-04-04 | Astra Pharma Prod | New compounds |
| SE9702774D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
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| EP1086233A2 (en) * | 1998-06-08 | 2001-03-28 | McMaster, Christopher | Cloning of human choline / ethanolaminephospho - transferases; synthesis of phosphatidyl - choline, phosphatidyle - thanolamine, and platelet activating factor |
| SE9804175D0 (sv) | 1998-12-02 | 1998-12-02 | Astra Pharma Prod | New assay |
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
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| US6399335B1 (en) * | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
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| US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| CA2328684A1 (en) * | 2000-12-15 | 2002-06-15 | Yahia Gawad | Photon-triggered luminescent assay |
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| US7115585B2 (en) | 2006-10-03 |
| EP1545555A2 (en) | 2005-06-29 |
| WO2003072067A3 (en) | 2005-04-28 |
| JP4745610B2 (ja) | 2011-08-10 |
| US20030008834A1 (en) | 2003-01-09 |
| MXPA04008293A (es) | 2004-11-26 |
| AR038612A1 (es) | 2005-01-19 |
| JP2005526046A (ja) | 2005-09-02 |
| CN1671398A (zh) | 2005-09-21 |
| CA2477241C (en) | 2012-04-10 |
| CA2477241A1 (en) | 2003-09-04 |
| AU2003223225B2 (en) | 2007-02-22 |
| AU2003223225A1 (en) | 2003-09-09 |
| BR0307783A (pt) | 2005-09-13 |
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