CA2477241C - Compositions and methods for treating epithelial and retinal tissue diseases - Google Patents
Compositions and methods for treating epithelial and retinal tissue diseases Download PDFInfo
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- CA2477241C CA2477241C CA2477241A CA2477241A CA2477241C CA 2477241 C CA2477241 C CA 2477241C CA 2477241 A CA2477241 A CA 2477241A CA 2477241 A CA2477241 A CA 2477241A CA 2477241 C CA2477241 C CA 2477241C
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US10/082,998 US7115585B2 (en) | 2000-08-21 | 2002-02-27 | Compositions for treating epithelial and retinal tissue diseases |
| US10/082,998 | 2002-02-27 | ||
| PCT/US2003/006691 WO2003072067A2 (en) | 2002-02-27 | 2003-02-27 | Compositions and methods for treating epithelial and retinal tissue diseases |
Publications (2)
| Publication Number | Publication Date |
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| CA2477241A1 CA2477241A1 (en) | 2003-09-04 |
| CA2477241C true CA2477241C (en) | 2012-04-10 |
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| MX (1) | MXPA04008293A (OSRAM) |
| TW (1) | TW200408399A (OSRAM) |
| WO (1) | WO2003072067A2 (OSRAM) |
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| US7435724B2 (en) * | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| WO2006071186A1 (en) * | 2004-12-27 | 2006-07-06 | Astrazeneca Ab | Use of gabab receptor agonists |
| US7741473B2 (en) * | 2005-03-30 | 2010-06-22 | Inspire Pharmaceuticals, Inc. | Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles |
| KR100870104B1 (ko) * | 2005-11-28 | 2008-11-26 | 주식회사 머젠스 | 안구건조증 치료 및 예방용 조성물 |
| EP2123285A1 (en) * | 2008-05-21 | 2009-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleosidic phosphoantigens for use in VGAMMA9DELTA2 T cell-mediated therapy |
| GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| EP2646449B1 (en) * | 2010-12-01 | 2015-08-19 | Bar-Ilan University | Uridine di- or tri-phosphate derivatives and uses thereof |
| CN103429605B (zh) * | 2011-01-26 | 2017-11-07 | 北京康倍得医药技术开发有限公司 | 呋喃核糖基嘌呤类化合物及其制备方法和应用 |
| WO2014060941A2 (en) * | 2012-10-17 | 2014-04-24 | Mahesh Kandula | Compositions and methods of neuroprotective agents for the treatment of neurological and neurodegenerative diseases |
| KR102883682B1 (ko) | 2016-02-18 | 2025-11-10 | 인버사, 인크. | 5'-아데노신 디포스페이트 리보오스 (adpr)의 사용 방법 |
| MX2019013363A (es) * | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| EP3746134A1 (en) | 2018-02-02 | 2020-12-09 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
| US10946034B2 (en) | 2018-03-27 | 2021-03-16 | Invirsa, Inc. | Methods for the use of 5′-adenosine diphosphate ribose (ADPR) |
| US11530234B2 (en) | 2018-09-11 | 2022-12-20 | Risen (Suzhou) Pharma Tech Co., Ltd. | CD73 inhibitors and pharmaceutical uses thereof |
| EP3849992A4 (en) | 2018-09-11 | 2022-06-29 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
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| US3321462A (en) * | 1963-07-15 | 1967-05-23 | Syntex Corp | Process for the preparation of nucleoside polyphosphates |
| US3324110A (en) * | 1965-02-05 | 1967-06-06 | Schering Corp | Method of phosphorylation and novel intermediates produced thereby |
| JPS509872B1 (OSRAM) * | 1969-12-22 | 1975-04-16 | ||
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| JPS5427581A (en) * | 1977-08-02 | 1979-03-01 | Mitsubishi Chem Ind Ltd | P1-s-phenylthiop2-nucleoside 5'-pyrophosphates and their preparation |
| US4386078A (en) * | 1980-03-03 | 1983-05-31 | The Ohio State University Research Foundation | Therapeutic agents for preventing phospholipid degradation and free fatty acid proliferation |
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| JPS62265299A (ja) * | 1985-12-18 | 1987-11-18 | Senjiyu Seiyaku Kk | α―トコフェロールとウリジンとのリン酸ジエステル，そのハロゲン置換体もしくはこれらの塩およびそれらの製造法 |
| AU1790988A (en) * | 1987-05-19 | 1988-12-21 | Baylor College Of Medicine | Phosphoethanolamine for treatment of alzheimer's disease |
| EP0508687B1 (en) | 1991-04-06 | 1995-09-13 | Astra Pharmaceuticals Limited | ATP analogues |
| US5654285A (en) * | 1991-04-06 | 1997-08-05 | Astra Pharmaceuticals Limited | ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| PL175623B1 (pl) | 1993-02-10 | 1999-01-29 | Astra Pharma Prod | N-alkilo-2-podstawione analogi ATP, sposób ich wytwarzania i kompozycja farmaceutyczna je zawierająca |
| US5444541A (en) * | 1994-02-16 | 1995-08-22 | Eastern Washington University | Methods for photoacoustically analyzing chemicals and chemical reactions using photoactive particle-emitting compounds |
| US5536822A (en) * | 1994-03-09 | 1996-07-16 | University Of Virginia Alumni Patents Foundation | γ-phosphate linked adenosine 5' triphosphate sepharose |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| TW427996B (en) * | 1995-07-11 | 2001-04-01 | Astra Pharma Prod | Novel triazolopyrimidines and their use as medicaments |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US5981507A (en) * | 1995-12-14 | 1999-11-09 | Advanced Magnetics, Inc. | Polymeric carriers linked to nucleotide analogues via a phosphoramide bond |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US6319908B1 (en) * | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| JP2001504097A (ja) * | 1996-10-30 | 2001-03-27 | ザ・ユニヴァーシティ・オブ・ノース・キャロライナ・アト・チャペル・ヒル | Ｐ２ｙレセプターアンタゴニスト |
| WO1998028300A1 (en) | 1996-12-20 | 1998-07-02 | Astra Pharmaceuticals Ltd. | Triazolo[4,5-d]pyrimidinyl derivatives and their use as medicaments |
| NZ337225A (en) * | 1997-02-06 | 2002-03-28 | Inspire Pharmaceuticals Inc | Dinucleotides useful for treating chronic pulmonary obstructive disorder |
| SE9701219D0 (sv) * | 1997-04-04 | 1997-04-04 | Astra Pharma Prod | New compounds |
| SE9702774D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| CA2332540A1 (en) * | 1998-05-22 | 1999-12-02 | Benjamin R. Yerxa | Therapeutic dinucleotide and derivatives |
| US6451568B1 (en) * | 1998-06-08 | 2002-09-17 | Dalhousie University | Cloning of human choline ethanolaminephospho transferases synthesis of phosphatidyl choline phosphatidyle thanolamine and platelet activating factor |
| SE9804175D0 (sv) | 1998-12-02 | 1998-12-02 | Astra Pharma Prod | New assay |
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
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| US6399335B1 (en) * | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
| SE9904377D0 (sv) | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| CA2328684A1 (en) * | 2000-12-15 | 2002-06-15 | Yahia Gawad | Photon-triggered luminescent assay |
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| AU2003223225B2 (en) | 2007-02-22 |
| MXPA04008293A (es) | 2004-11-26 |
| JP4745610B2 (ja) | 2011-08-10 |
| KR20040094736A (ko) | 2004-11-10 |
| US7115585B2 (en) | 2006-10-03 |
| AR038612A1 (es) | 2005-01-19 |
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