TW200406399A - Substituted heterocyclic compounds and methods of use - Google Patents

Substituted heterocyclic compounds and methods of use Download PDF

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Publication number
TW200406399A
TW200406399A TW092113725A TW92113725A TW200406399A TW 200406399 A TW200406399 A TW 200406399A TW 092113725 A TW092113725 A TW 092113725A TW 92113725 A TW92113725 A TW 92113725A TW 200406399 A TW200406399 A TW 200406399A
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Taiwan
Prior art keywords
methyl
substituted
alkyl
phenyl
group
Prior art date
Application number
TW092113725A
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English (en)
Chinese (zh)
Inventor
Celia Dominguez
Da-Wei Zhang
Guo-Qiang Cao
Martin H Goldberg
Fang-Tsao Hong
K C Sham Kelvin
Tadesse Seifu
A Tamayo Nuria
E Weiler Kurt
Liao Hongyu
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Amgen Inc
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Publication of TW200406399A publication Critical patent/TW200406399A/zh

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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TW092113725A 2002-05-21 2003-05-21 Substituted heterocyclic compounds and methods of use TW200406399A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38269902P 2002-05-21 2002-05-21
US10/438,553 US7026326B2 (en) 2002-05-21 2003-05-13 Substituted heterocyclic compounds and methods of use

Publications (1)

Publication Number Publication Date
TW200406399A true TW200406399A (en) 2004-05-01

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TW092113725A TW200406399A (en) 2002-05-21 2003-05-21 Substituted heterocyclic compounds and methods of use

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US (1) US7026326B2 (enExample)
EP (1) EP1506186A1 (enExample)
JP (2) JP4606161B2 (enExample)
AR (1) AR039842A1 (enExample)
AU (1) AU2003234628B2 (enExample)
CA (1) CA2485166A1 (enExample)
MX (1) MXPA04011470A (enExample)
PL (1) PL376575A1 (enExample)
TW (1) TW200406399A (enExample)
WO (1) WO2003099808A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1654250A1 (en) * 2003-07-25 2006-05-10 Amgen Inc. Substituted pyridones and pyrimidinones with antiinflammatory properties
EP1656366A1 (en) * 2003-08-20 2006-05-17 Amgen Inc. Substituted pyrimdinone derivatives and methods of use
AU2005317769A1 (en) * 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor (GPR116) agonists and use thereof for treating obesity and diabetes
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
US8062824B2 (en) * 2006-07-17 2011-11-22 E. I. Du Pont De Nemours And Company Thermally imageable dielectric layers, thermal transfer donors and receivers
US7528448B2 (en) * 2006-07-17 2009-05-05 E.I. Du Pont De Nemours And Company Thin film transistor comprising novel conductor and dielectric compositions
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TWI475995B (zh) 2007-09-14 2015-03-11 詹森藥物公司 1’,3’-二取代-4-苯基-3,4,5,6-四氫-2h,1’h-〔1,4’〕聯吡啶基-2’-酮化物
US7666567B2 (en) 2007-10-23 2010-02-23 E. I. Du Pont De Nemours And Company Negative imaging method for providing a patterned metal layer having high conductivity
US7666568B2 (en) * 2007-10-23 2010-02-23 E. I. Du Pont De Nemours And Company Composition and method for providing a patterned metal layer having high conductivity
MX2011002042A (es) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico.
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AR076859A1 (es) 2009-05-12 2011-07-13 Ortho Mcneil Janssen Pharm Derivados de 1,2,4-triazolo[4,3-a]piridina moduladores alostericos positivos de receptores mglur2 , composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos neurologicos y siquiatricos.
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
WO2012062751A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852666B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CN103635472B (zh) 2011-02-28 2018-01-12 阵列生物制药公司 丝氨酸/苏氨酸激酶抑制剂
EP2739618B1 (en) 2011-08-04 2015-09-16 Array Biopharma, Inc. Quinazoline compounds as serine/threonine kinase inhibitors
WO2013066729A1 (en) * 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
KR102093526B1 (ko) 2012-03-01 2020-03-25 어레이 바이오파마 인크. 세린/트레오닌 키나제 억제제
AR092253A1 (es) 2012-08-27 2015-04-08 Array Biopharma Inc Inhibidores de serina/treonina cinasa
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
CN109999025A (zh) 2014-01-21 2019-07-12 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
JP7071965B2 (ja) * 2017-04-11 2022-05-19 三井化学アグロ株式会社 ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤
SMT202200493T1 (it) * 2017-08-23 2023-01-13 Sprint Bioscience Ab Composti di piridinammina-piridone e pirimidinammina-piridone
TWI787335B (zh) * 2017-08-23 2022-12-21 瑞典商斯普林特生物科技公司 吡啶基吡啶酮化合物
WO2020163689A1 (en) 2019-02-08 2020-08-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 20-hete formation inhibitors
EP4251152A1 (en) 2020-11-25 2023-10-04 Deciphera Pharmaceuticals, LLC Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection
IL314895A (en) * 2022-02-16 2024-10-01 Duke Street Bio Ltd Pharmaceutical compound
WO2024119067A1 (en) 2022-12-02 2024-06-06 Neumora Therapeutics, Inc. Methods of treating neurological disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2602794A (en) * 1952-07-08 Process for preparation of x-amino-s
WO1995009917A1 (en) 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies
DE69534265T2 (de) 1994-12-12 2006-05-04 Beth Israel Deaconess Medical Center, Inc., Boston Chimäre zytokine und ihre verwendung
NZ503548A (en) 1996-02-09 2001-09-28 Amgen Inc A fusion protein comprising an IL-1ra receptor antagonist with a constant domain of human immunoglobulin at the carboxy terminus
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US6410729B1 (en) * 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
JP2002514196A (ja) * 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジノンおよびピリドン化合物ならびに使用方法
JP2002514195A (ja) * 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジン化合物およびそれの使用
US6096753A (en) * 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
WO1998024477A1 (en) 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
KR19980066046A (ko) 1997-01-18 1998-10-15 정용훈 고역가의 CTLA4-Ig 융합단백질
CN1202862C (zh) 1997-04-17 2005-05-25 安姆根有限公司 包含具有抗体Fc链的稳定、有活性人OB蛋白的结合物的组合物及方法
MXPA03008121A (es) * 2001-03-15 2003-12-12 Basf Ag 5-fenilpirimidinas, metodos y productos intermedios para su produccion y uso de las mismas para controlar hongos patogenicos.

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JP2005530810A (ja) 2005-10-13
JP2010280669A (ja) 2010-12-16
US7026326B2 (en) 2006-04-11
WO2003099808A1 (en) 2003-12-04
PL376575A1 (pl) 2006-01-09
WO2003099808A8 (en) 2009-02-05
EP1506186A1 (en) 2005-02-16
AU2003234628A1 (en) 2003-12-12
US20050038010A1 (en) 2005-02-17
AR039842A1 (es) 2005-03-02

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