AR039842A1 - Compuestos heterociclicos sustituidos y metodos de empleo - Google Patents
Compuestos heterociclicos sustituidos y metodos de empleoInfo
- Publication number
- AR039842A1 AR039842A1 ARP030101777A ARP030101777A AR039842A1 AR 039842 A1 AR039842 A1 AR 039842A1 AR P030101777 A ARP030101777 A AR P030101777A AR P030101777 A ARP030101777 A AR P030101777A AR 039842 A1 AR039842 A1 AR 039842A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- independently
- instance
- nrgrg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- AIDS & HIV (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) o una de sus sales farmacéuticamente aceptable, donde: n es 0, 1 ó 2; R1 es una cadena cerrada de 5, 6 ó 7 miembros, saturada o insaturada, que contiene 0, 1, 2 ó 3 átomos seleccionados de N, O y S, donde la cadena cerrada puede estar fusionada con un grupo benzo, y está sustituida por 0, 1 ó 2 grupos oxo, y donde R1 está adicionalmente sustituido por 0, 1, 2 ó 3 sustituyentes seleccionados de Rd y alquilo C1-4Rd; R2 es alquilo C1-6 sustituido con 1, 2 ó 3 grupos Rd y 0 ó 1 grupos Rc, que están sustituidos por 0, 1 ó 2 grupos Rd, donde R2 no es -C(=O)Obencilo; y donde -R1-R2 no es 3-bencilpiperazin-1-ilo; y donde si tanto R3 como R4 son 4-metilfenilo, -R1-R2 no es 4-(hidroximetil)piperidin-1-ilo; R3 es Rc sustituido por 0, 1, 2 ó 3 sustituyentes seleccionados de Rf y Rd; R4 es Rc sustituido por 0, 1, 2 ó 3 sustituyentes seleccionados de Rf y Rd que no incluyen 1-feniletilamino; siempre que el número total de grupos Rc sustituidos en cada uno de R3 y R4 sea 0 ó 1; R5 es independientemente en cada instancia H, alquilo C1-8 o alquilo C1-6Rc, ambos sustituidos por 0, 1, 2 ó 3 sustituyentes seleccionados de Rd; R6 es independientemente en cada instancia alquilo C1-8 o alquilo C1-6Rc, ambos sustituidos por 0, 1, 2 ó 3 sustituyentes seleccionados de Rd; o R6 es Rd; R7 es independientemente hidrógeno, -alquilo C1-6 o -alquilo C1-4Rc, donde cualquier átomo de carbono de la estructura anterior está sustituido por 0 a 3 sustituyentes seleccionados de Rd; Ra es independientemente en cada instancia h O Rb; Rb es independientemente en cada instancia alquilo C1-8, Rc o alquilo C1-4Rc, cada uno de los cuales está sustituido por 0, 1, 2 ó 3 sustituyentes seleccionados independientemente de Rd; Rc es independientemente en cada instancia arilo o una cadena cerrada heterocíclica de 5, 6 ó 7 miembros saturado o insaturada, que contiene 1, 2 ó 3 átomos seleccionados de N, O y S, donde la cadena cerrada está fusionada con 0 ó 1 grupos benzo y 0 ó 1 cadenas cerradas heterocíclicas de 5, 6 ó 7 miembros, saturadas o insaturadas, que contienen 1, 2 ó 3 átomos seleccionados de N, O y S; donde cualquier cadena cerrada heterocíclica está sustituida por 0, 1 ó 2 grupos oxo; Rd es independientemente en cada instancia alquilo C1-6, halo, haloalquilo C1-4, ciano, -C(=O)Rf, -C(=O)ORe, -C(=O)NRgRg, -C(=NRg)NRgRg, -ORe, --OC(=O)Re, -OC(=O)NRgRg, -OC(=O)N(Rh)S(=O)2Rf, -SRe, -S(=O)Rf, -S(=O)2Rf, -S(=O)2NRgRg, -S(=O)2N(Rh)C(=O)Rf, -S(=O)2N(Rh)C(=O)ORf, -S(=O)2-N(Rh)C(=O)NRgRg, -NRgRg, -N(Rh)C(=O)Re, -N(Rh)C(=O)ORf, -N(Rh)C(=O)NRgRg, -N(Rh)C(=NRg)NRgRg, -N(Rh)S(=O)2Rf ó -N(Rh)S(=O)NRgRg; Re es independientemente en cada instancia hidrógeno o Rf; Rf es independientemente en cada instancia Rc o alquilo C1-8, cualquiera de los cuales está sustituido por 0 a 3 sustituyentes seleccionados de -NRgRg, -C(=O)ORi, -ORi,-N(Ri)C(=O)Rk, -N(Ri)C(=O)ORi, -N(Ri)S(=O)2Rk, -S(=O)nRk, ciano, halo, -O alquilo C1-4 Rc, -S(=O)n alquilo C1-4 Rc y Rc, donde cualquier Rc en Rf puede estar sustituido, también, por alquilo C1-8 o haloalquilo C1-4; Rg es independientemente en cada instancia hidrógeno, Rc, alquilo C1-10 o -alquilo C1-4Rc, donde cada uno está sustituido por 0 a 3 sustituyentes seleccionados de -NRiRi, -N(Ri)C(=O)Rk, -N(Ri)C(=O)ORk, -N(Ri)S(=O)2Rk, -ORi, -S(=O)nRk, ciano, alquilo C1-8 y haloalquilo C1-4; Rh independientemente en cada instancia hidrógeno, alquilo C1-8 o alquilo C1-4Rc cada uno de los cuales está sustituido por 0 a 3 sustituyentes seleccionados de -NRiRi, -N(Ri)C(=O)Rk, -N(Ri)C(=O)ORk, -N(Ri)S(=O)2Rk, -ORi, -S(=O)nRk, ciano, alquilo C1-8 y haloalquilo C1-4; Ri es Rk o hidrógeno; Rk es alquilo C1-6, fenilo o bencilo; V es -N=, -NR5-, -CR6=, C=O, C=S o C=NR7; W es -N=, -NR5-, -CR6=, C=O, C=S o C=NR7; y X es -N=, -NR5-, -CR6=, C=O, C=S o C=NR7; donde el número total de grupos -NR5-, C=O, C=S o C=NR7 representados por V, W y X debe ser 0 ó 2; y al menos uno de V, W y X contiene un átomo de N. También se incluye un método para la profilaxis o el tratamiento de: inflamación, artritis reumatoidea, mal de Paget, osteoporosis, mieloma múltiple, uveitis, leucemia mielógeno aguda o crónica, destrucción de las células beta pancreáticas, osteoartritis, espondilitis reumatoidea, artiritis gotosa, enfermedad inflamatoria intestinal, síndrome de distrés respiratorio del adulto [ARDS, por sus siglas en inglés], soriasis, enfermedad de Crohn, rinitis alérgica, colitis ulcerosa, anafilaxis, dermatitis por contacto, asma, degeneración muscular, caquexia, síndrome de Reiter, diabetes del tipo I y del tipo II, enfermedades relacionadas con la resorción ósea, reacción injerto contra huésped, Mal de Alzheimer, ataque cerebrovascular, infarto del miocardio, lesión por isquemia-reperfusión, ateroesclerosis, trauma cerebral, esclerosis múltiple, malaria cerebral, sepsis, choque séptico, síndrome de choque tóxico, fiebre, mialgias padecidas a raíz de infecciones por VIH-1, VIH-2, VIH-3, citomegalovirus [CMV], gripe, adenovirus, herpes viral o infección por herpes zóster en un mamífero, que comprende la administración de una cantidad eficaz de un compuesto tal como el que se describió previamente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38269902P | 2002-05-21 | 2002-05-21 | |
US10/438,553 US7026326B2 (en) | 2002-05-21 | 2003-05-13 | Substituted heterocyclic compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039842A1 true AR039842A1 (es) | 2005-03-02 |
Family
ID=29584444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101777A AR039842A1 (es) | 2002-05-21 | 2003-05-22 | Compuestos heterociclicos sustituidos y metodos de empleo |
Country Status (10)
Country | Link |
---|---|
US (1) | US7026326B2 (es) |
EP (1) | EP1506186A1 (es) |
JP (2) | JP4606161B2 (es) |
AR (1) | AR039842A1 (es) |
AU (1) | AU2003234628B2 (es) |
CA (1) | CA2485166A1 (es) |
MX (1) | MXPA04011470A (es) |
PL (1) | PL376575A1 (es) |
TW (1) | TW200406399A (es) |
WO (1) | WO2003099808A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004261587B2 (en) * | 2003-07-25 | 2008-02-21 | Amgen Inc. | Substituted pyridones and pyrimidinones with antiinflammatory properties |
CA2535644A1 (en) * | 2003-08-20 | 2005-03-03 | Amgen Inc. | Substituted pyrimdinone derivatives and methods of use |
JP4980928B2 (ja) * | 2004-12-24 | 2012-07-18 | プロシディオン・リミテッド | Gタンパク質共役受容体(gpr116)作動薬および肥満および糖尿病治療のためのその使用 |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
US8062824B2 (en) * | 2006-07-17 | 2011-11-22 | E. I. Du Pont De Nemours And Company | Thermally imageable dielectric layers, thermal transfer donors and receivers |
US7528448B2 (en) * | 2006-07-17 | 2009-05-05 | E.I. Du Pont De Nemours And Company | Thin film transistor comprising novel conductor and dielectric compositions |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
US7666568B2 (en) * | 2007-10-23 | 2010-02-23 | E. I. Du Pont De Nemours And Company | Composition and method for providing a patterned metal layer having high conductivity |
US7666567B2 (en) | 2007-10-23 | 2010-02-23 | E. I. Du Pont De Nemours And Company | Negative imaging method for providing a patterned metal layer having high conductivity |
WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
SG10201402250TA (en) | 2009-05-12 | 2014-07-30 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
WO2012062750A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
US9133187B2 (en) | 2011-02-28 | 2015-09-15 | Array Biopharma Inc. | Serine/threonine kinase inhibitors |
RU2014108140A (ru) | 2011-08-04 | 2015-09-10 | Эррэй Биофарма Инк. | Соединение на основе хинозолина в качестве ингибиторов серен-треониновых киназ |
WO2013066729A1 (en) * | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
ES2857649T3 (es) * | 2012-03-01 | 2021-09-29 | Array Biopharma Inc | Inhibidores de serina/treonina cinasa |
KR20150047597A (ko) | 2012-08-27 | 2015-05-04 | 어레이 바이오파마 인크. | 과증식성 질환의 치료를 위한 세린/트레오닌 키나아제 억제제 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
EA201891617A3 (ru) | 2014-01-21 | 2019-04-30 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
AU2018251415B2 (en) * | 2017-04-11 | 2021-08-05 | Mitsui Chemicals Crop & Life Solutions, Inc. | Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients |
CN116041321A (zh) * | 2017-08-23 | 2023-05-02 | 思普瑞特生物科学公司 | 吡啶胺-吡啶酮化合物和嘧啶胺-吡啶酮化合物 |
PL3672941T3 (pl) * | 2017-08-23 | 2022-06-13 | Sprint Bioscience Ab | Związki pirydylopirydonu |
WO2022115545A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection |
WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
US11993580B1 (en) | 2022-12-02 | 2024-05-28 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2602794A (en) * | 1952-07-08 | Process for preparation of x-amino-s | ||
WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
EP1621206A1 (en) | 1994-12-12 | 2006-02-01 | Beth Israel Deaconess Medical Center, Inc. | Chimeric cytokines and uses thereof |
IL125552A0 (en) | 1996-02-09 | 1999-03-12 | Amgen Inc | Composition comprising interleukin-1 inhibitor and controlled release polymer |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
WO1998024780A2 (en) * | 1996-12-05 | 1998-06-11 | Amgen Inc. | Substituted pyrimidinone and pyridinone compounds and their use |
AR038955A1 (es) | 1996-12-05 | 2005-02-02 | Amgen Inc | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso |
US6096753A (en) * | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
US6410729B1 (en) * | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
DE69738948D1 (de) | 1996-12-06 | 2008-10-09 | Amgen Inc | Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten |
KR19980066046A (ko) | 1997-01-18 | 1998-10-15 | 정용훈 | 고역가의 CTLA4-Ig 융합단백질 |
CN1202862C (zh) | 1997-04-17 | 2005-05-25 | 安姆根有限公司 | 包含具有抗体Fc链的稳定、有活性人OB蛋白的结合物的组合物及方法 |
EP1373222A2 (de) * | 2001-03-15 | 2004-01-02 | Basf Aktiengesellschaft | 5-phenylpyrimidine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von schadpilzen |
-
2003
- 2003-05-13 JP JP2004507465A patent/JP4606161B2/ja not_active Expired - Fee Related
- 2003-05-13 US US10/438,553 patent/US7026326B2/en not_active Expired - Lifetime
- 2003-05-13 WO PCT/US2003/015473 patent/WO2003099808A1/en active Search and Examination
- 2003-05-13 CA CA002485166A patent/CA2485166A1/en not_active Abandoned
- 2003-05-13 AU AU2003234628A patent/AU2003234628B2/en not_active Ceased
- 2003-05-13 MX MXPA04011470A patent/MXPA04011470A/es active IP Right Grant
- 2003-05-15 PL PL376575A patent/PL376575A1/pl not_active Application Discontinuation
- 2003-05-15 EP EP03728971A patent/EP1506186A1/en not_active Withdrawn
- 2003-05-21 TW TW092113725A patent/TW200406399A/zh unknown
- 2003-05-22 AR ARP030101777A patent/AR039842A1/es not_active Application Discontinuation
-
2010
- 2010-07-09 JP JP2010157000A patent/JP2010280669A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2005530810A (ja) | 2005-10-13 |
TW200406399A (en) | 2004-05-01 |
CA2485166A1 (en) | 2003-12-04 |
PL376575A1 (pl) | 2006-01-09 |
WO2003099808A1 (en) | 2003-12-04 |
EP1506186A1 (en) | 2005-02-16 |
US20050038010A1 (en) | 2005-02-17 |
AU2003234628A1 (en) | 2003-12-12 |
MXPA04011470A (es) | 2005-02-14 |
US7026326B2 (en) | 2006-04-11 |
AU2003234628B2 (en) | 2007-08-23 |
JP4606161B2 (ja) | 2011-01-05 |
WO2003099808A8 (en) | 2009-02-05 |
JP2010280669A (ja) | 2010-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR039842A1 (es) | Compuestos heterociclicos sustituidos y metodos de empleo | |
KR101930106B1 (ko) | 지질 합성의 헤테로사이클릭 조절자 | |
BR112020018610A2 (pt) | Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas | |
NO20076185L (no) | 2-amido-6-amino-8-oksopurinderivater som "Toll-like receptor" modulatorer for behandling av cancer og virale infeksjoner slik som hepatitt C | |
AR104417A2 (es) | Compuestos de tiadiazolidina, procedimiento para su preparación, composición farmacéutica que lo compone y usos de dichos compuestos | |
CA2945693C (en) | 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication | |
PE20141010A1 (es) | Derivados de piridin-2(1h)-ona utiles como medicamentos para el tratamiento de transtornos mieloproliferativos, rechazo de transplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias | |
AU612350B2 (en) | Novel thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions | |
JP2007530598A5 (es) | ||
WO2010117926A1 (en) | Substituted triazolopyridines and analogs thereof | |
RU2008133382A (ru) | Соединения гидантоина для лечения воспалительных заболеваний | |
WO2010053438A1 (en) | Modulators of amyloid beta. | |
CA2682473A1 (en) | Novel pyrrolinone derivative and pharmaceutical composition comprising the same | |
JP6372666B2 (ja) | サイトメガロウイルスの阻害剤 | |
AR054208A1 (es) | Derivados de oxopiperidina, su preparacion, una composicion farmaceutica y compuestos intermediarios | |
JP6567505B2 (ja) | キナゾリン誘導体およびdnaメチルトランスフェラーゼ阻害剤としてのその使用 | |
AR078321A1 (es) | Derivados de 2,4'-bipiridina como inhibidores de cinasa (cdk9) | |
PE20220252A1 (es) | Compuestos de pirrol | |
CA2488761A1 (en) | 2-benzofuryl or benzothiophenyl-quinuclidinyl amides as nicotinic acetylcholine receptor inhibitors | |
AR040253A1 (es) | Fluorobenzamidas, procesos de preparacion y medicamento | |
KR20090029182A (ko) | 단백질 키나제 억제제로서 티아졸릴디하이드로인다졸 유도체 | |
CS224634B2 (en) | Method for producong a derivate of 5,6,7,7a-tetrahydro-4h-thieno-/3,2-c/pyridin-2-one | |
ATE393157T1 (de) | Substituierte heterocyclische verbindungen und anwendungsverfahren | |
HUP0001698A2 (hu) | Szubsztituált pirimidinszármazékok és ezeket tartalmazó gyógyászati készítmények | |
EA032872B1 (ru) | Макроциклические ингибиторы rip2-киназы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |