TR201910409T4 - Sitrülin barındıran adjuvan bileşimi. - Google Patents
Sitrülin barındıran adjuvan bileşimi. Download PDFInfo
- Publication number
- TR201910409T4 TR201910409T4 TR2019/10409T TR201910409T TR201910409T4 TR 201910409 T4 TR201910409 T4 TR 201910409T4 TR 2019/10409 T TR2019/10409 T TR 2019/10409T TR 201910409 T TR201910409 T TR 201910409T TR 201910409 T4 TR201910409 T4 TR 201910409T4
- Authority
- TR
- Turkey
- Prior art keywords
- adjuvant composition
- composition
- adjuvant
- composition containing
- containing citrulline
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title abstract 7
- 235000013477 citrulline Nutrition 0.000 title abstract 2
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 title 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 title 1
- 229960002173 citrulline Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 abstract 3
- 229940037003 alum Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Alüm gibi geleneksel adjuvana kıyasla güvenlik ve uygunluk bakımından mükemmel olan yeni bir adjuvan bileşimi sağlanmaktadır. Canlı vücutta bulunan suda çözünü madde olan sitrülinleri ve/veya bunun bir tuzunu içeren bir adjuvan bileşimi; söz konusu adjuvan bileşimi ve bir antijeni içeren bir aşı bileşimi; söz konusu adjuvan bileşiminin ve söz konusu aşı bileşiminin hazırlanmasına yönelik bir proses; ve söz konusu adjuvan bileşimi ve söz konusu aşı bileşiminin uygulanmasına yönelik bir yöntem sağlanmaktadır.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011053658 | 2011-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201910409T4 true TR201910409T4 (tr) | 2019-08-21 |
Family
ID=46830703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/10409T TR201910409T4 (tr) | 2011-03-11 | 2012-03-09 | Sitrülin barındıran adjuvan bileşimi. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9381242B2 (tr) |
| EP (1) | EP2684572B1 (tr) |
| JP (1) | JP5914458B2 (tr) |
| KR (1) | KR101847848B1 (tr) |
| CN (1) | CN103561764B (tr) |
| ES (1) | ES2731636T3 (tr) |
| TR (1) | TR201910409T4 (tr) |
| WO (1) | WO2012124631A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106232577B (zh) | 2014-04-25 | 2019-02-22 | 味之素株式会社 | 免疫刺激剂 |
| JP2018188434A (ja) | 2017-04-28 | 2018-11-29 | 味の素株式会社 | 免疫賦活剤 |
| CA3121613A1 (en) * | 2018-12-26 | 2020-07-02 | Sumitomo Dainippon Pharma Co., Ltd. | Preparation including vaccine adjuvant |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725545A (en) * | 1971-02-03 | 1973-04-03 | R Maes | Enhancement of antibody production by nucleic acid-polycation complexes |
| JPS5375387A (en) | 1976-12-13 | 1978-07-04 | Kyowa Hakko Kogyo Co Ltd | Preparation of l-citrulline |
| JPH0755155B2 (ja) | 1986-09-10 | 1995-06-14 | 協和醗酵工業株式会社 | アミノ酸の製造法 |
| US20040062773A1 (en) * | 1993-04-22 | 2004-04-01 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
| US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| WO1997049430A1 (en) * | 1996-06-26 | 1997-12-31 | Antigen Express, Inc. | Immunotherapy by modulation of antigen presentation |
| US20010056068A1 (en) * | 1998-03-04 | 2001-12-27 | Kristof Chwalisz | Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives |
| JP3843298B2 (ja) | 2001-02-05 | 2006-11-08 | 国立大学法人 奈良先端科学技術大学院大学 | シトルリンを含有する活性酸素消去剤 |
| PT1909830E (pt) * | 2005-08-02 | 2011-11-24 | Novartis Vaccines & Diagnostic | Redução de interferência entre adjuvantes contendo óleo e antigénios contendo tensioactivos |
| WO2009053535A2 (en) * | 2007-10-26 | 2009-04-30 | Glykos Finland Oy | Peptide vaccine for influenza virus |
| EP3011961B1 (en) * | 2006-12-21 | 2020-11-11 | Biokine Therapeutics LTD. | 4f-benzoyl-tn14003 for the mobilisation of hematopoietic progenitor cells in view of transplantation |
| JP5349297B2 (ja) | 2007-04-20 | 2013-11-20 | 一般財団法人化学及血清療法研究所 | ペプチド免疫応答増強方法 |
| CN102215836B (zh) * | 2008-09-19 | 2015-07-08 | 雀巢产品技术援助有限公司 | 预防或减轻在抗癌治疗期间的骨髓瘫痪或中性白细胞减少症的营养支持 |
| BRPI1005670A8 (pt) * | 2009-01-05 | 2017-12-26 | Epitogenesis Inc | composições adjuvantes e processos de uso. |
| AU2010282169A1 (en) * | 2009-08-10 | 2012-03-08 | Immunotech Developments Inc. | Vaccine having a peptide adjuvant for eliciting a specific immune response to treat viral infection and other conditions |
| CN102612559B (zh) | 2009-08-28 | 2015-06-10 | 一般财团法人化学及血清疗法研究所 | 源自流感m2的修饰的肽疫苗 |
| EP2545071A2 (en) * | 2010-03-09 | 2013-01-16 | Maksyutov, Amir | Polyepitope constructs and methods for their preparation and use |
-
2012
- 2012-03-09 EP EP12757500.9A patent/EP2684572B1/en active Active
- 2012-03-09 TR TR2019/10409T patent/TR201910409T4/tr unknown
- 2012-03-09 CN CN201280022634.6A patent/CN103561764B/zh active Active
- 2012-03-09 US US14/004,308 patent/US9381242B2/en active Active
- 2012-03-09 JP JP2013504708A patent/JP5914458B2/ja active Active
- 2012-03-09 ES ES12757500T patent/ES2731636T3/es active Active
- 2012-03-09 WO PCT/JP2012/056132 patent/WO2012124631A1/ja active Application Filing
- 2012-03-09 KR KR1020137025814A patent/KR101847848B1/ko active IP Right Grant
-
2016
- 2016-05-31 US US15/168,839 patent/US10556005B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5914458B2 (ja) | 2016-05-11 |
| EP2684572A1 (en) | 2014-01-15 |
| US20170239348A1 (en) | 2017-08-24 |
| CN103561764B (zh) | 2015-09-16 |
| WO2012124631A1 (ja) | 2012-09-20 |
| US10556005B2 (en) | 2020-02-11 |
| JPWO2012124631A1 (ja) | 2014-07-24 |
| US20140065179A1 (en) | 2014-03-06 |
| CN103561764A (zh) | 2014-02-05 |
| US9381242B2 (en) | 2016-07-05 |
| EP2684572A4 (en) | 2014-09-10 |
| EP2684572B1 (en) | 2019-05-22 |
| KR20140012115A (ko) | 2014-01-29 |
| ES2731636T3 (es) | 2019-11-18 |
| KR101847848B1 (ko) | 2018-04-12 |
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