TR201908638T4 - Ang2 bağlayıcı moleküller. - Google Patents

Ang2 bağlayıcı moleküller. Download PDF

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Publication number
TR201908638T4
TR201908638T4 TR2019/08638T TR201908638T TR201908638T4 TR 201908638 T4 TR201908638 T4 TR 201908638T4 TR 2019/08638 T TR2019/08638 T TR 2019/08638T TR 201908638 T TR201908638 T TR 201908638T TR 201908638 T4 TR201908638 T4 TR 201908638T4
Authority
TR
Turkey
Prior art keywords
binding molecules
ang2 binding
ang2
vhhs
angiogenesis
Prior art date
Application number
TR2019/08638T
Other languages
English (en)
Turkish (tr)
Inventor
Borges Eric
Gschwind Andreas
Georg Ott Rene
Buyse Marie-Ange
Boucneau Joachim
Merchiers Pascal
Depla Erik
Stevenaert Frederik
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48190468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201908638(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TR201908638T4 publication Critical patent/TR201908638T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TR2019/08638T 2012-03-30 2013-03-27 Ang2 bağlayıcı moleküller. TR201908638T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12162615 2012-03-30

Publications (1)

Publication Number Publication Date
TR201908638T4 true TR201908638T4 (tr) 2019-07-22

Family

ID=48190468

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/08638T TR201908638T4 (tr) 2012-03-30 2013-03-27 Ang2 bağlayıcı moleküller.

Country Status (27)

Country Link
US (5) US20130259859A1 (cg-RX-API-DMAC7.html)
EP (1) EP2831111B1 (cg-RX-API-DMAC7.html)
JP (1) JP5970734B2 (cg-RX-API-DMAC7.html)
KR (1) KR102020255B1 (cg-RX-API-DMAC7.html)
CN (1) CN104321344B (cg-RX-API-DMAC7.html)
AU (1) AU2013241769B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014023415B1 (cg-RX-API-DMAC7.html)
CA (1) CA2865464C (cg-RX-API-DMAC7.html)
CL (1) CL2014002393A1 (cg-RX-API-DMAC7.html)
CY (1) CY1122007T1 (cg-RX-API-DMAC7.html)
DK (1) DK2831111T3 (cg-RX-API-DMAC7.html)
EA (1) EA031182B1 (cg-RX-API-DMAC7.html)
ES (1) ES2729165T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20190817T1 (cg-RX-API-DMAC7.html)
HU (1) HUE044263T2 (cg-RX-API-DMAC7.html)
IL (1) IL234234B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN06904A (cg-RX-API-DMAC7.html)
LT (1) LT2831111T (cg-RX-API-DMAC7.html)
MX (1) MX350248B (cg-RX-API-DMAC7.html)
NZ (1) NZ628584A (cg-RX-API-DMAC7.html)
PH (1) PH12014502179B1 (cg-RX-API-DMAC7.html)
PL (1) PL2831111T3 (cg-RX-API-DMAC7.html)
PT (1) PT2831111T (cg-RX-API-DMAC7.html)
RS (1) RS58732B1 (cg-RX-API-DMAC7.html)
SI (1) SI2831111T1 (cg-RX-API-DMAC7.html)
TR (1) TR201908638T4 (cg-RX-API-DMAC7.html)
WO (1) WO2013144266A1 (cg-RX-API-DMAC7.html)

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AU2016239949A1 (en) * 2015-03-31 2017-09-07 Sorriso Pharmaceuticals, Inc. Peptide construct having a protease-cleavable linker
RU2749674C2 (ru) 2015-07-29 2021-06-16 Аллерган, Инк. Антитела против ang-2, содержащие только тяжелую цепь
WO2018071824A1 (en) * 2016-10-13 2018-04-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for predicting response and resistance to ctla4 blockade in melanoma using a gene expression signature
KR102143132B1 (ko) * 2016-12-26 2020-08-10 기초과학연구원 항 Ang2 항체를 포함하는 안구질환 예방 및 치료용 조성물
EP3565839A4 (en) 2017-01-05 2021-04-21 Gensun Biopharma Inc. CHECKPOINT REGULATOR ANTAGONISTS
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JP2021529557A (ja) 2018-06-29 2021-11-04 ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． 抗腫瘍免疫チェックポイント調節因子アンタゴニスト
US20220204603A1 (en) * 2019-02-25 2022-06-30 Pharmabcine Inc. Anti-ang2 antibody and use thereof
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EP3990116A1 (en) 2019-06-28 2022-05-04 Gensun Biopharma Inc. ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
WO2021178209A1 (en) * 2020-03-03 2021-09-10 Aptitude Medical Systems, Inc. Aptamers and use thereof
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US20220389120A1 (en) 2021-06-03 2022-12-08 Gensun Biopharma Inc. Multispecific antagonists
EP4400512A4 (en) * 2021-09-10 2025-07-23 Soter Biopharma Pte Ltd ANTI-ANG2 ANTIBODY, ITS PREPARATION METHOD AND ITS USE
JP2025533028A (ja) 2022-09-28 2025-10-03 科▲興▼生物制▲薬▼股▲ふん▼有限公司 Ａｎｇ－２を認識できる抗体または抗原結合断片及びｖｅｇｆとａｎｇ－２を同時に認識できる二重抗体
CN115819592B (zh) * 2022-12-27 2026-04-24 上海医药集团生物治疗技术有限公司 靶向ror1的抗原结合蛋白
WO2025117641A2 (en) * 2023-12-01 2025-06-05 Tavotek Biotherapeutics (Hong Kong) Limited ANTIBODIES TARGETING DISEASE ASSOCIATED ANTIGEN AND γδ T CELL RECEPTORS AND USES THEREOF
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WO2026016001A1 (en) * 2024-07-15 2026-01-22 Quaerite Biopharm Research (Beijing) Co., Ltd. Anti-ang2 monospecific and multispecific antibody constructs

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Also Published As

Publication number Publication date
PH12014502179A1 (en) 2014-12-10
EA031182B1 (ru) 2018-11-30
EA201401065A1 (ru) 2015-03-31
US20230203146A1 (en) 2023-06-29
HUE044263T2 (hu) 2019-10-28
JP2015516805A (ja) 2015-06-18
BR112014023415B1 (pt) 2022-04-12
CL2014002393A1 (es) 2015-01-23
CA2865464A1 (en) 2013-10-03
DK2831111T3 (en) 2019-04-29
IN2014DN06904A (cg-RX-API-DMAC7.html) 2015-05-15
AU2013241769A1 (en) 2014-08-28
PT2831111T (pt) 2019-05-31
CY1122007T1 (el) 2020-10-14
CA2865464C (en) 2022-07-12
RS58732B1 (sr) 2019-06-28
SI2831111T1 (sl) 2019-06-28
JP5970734B2 (ja) 2016-08-17
NZ628584A (en) 2016-04-29
ES2729165T3 (es) 2019-10-30
WO2013144266A1 (en) 2013-10-03
US20190135907A1 (en) 2019-05-09
CN104321344A (zh) 2015-01-28
US20200207845A1 (en) 2020-07-02
US20130259859A1 (en) 2013-10-03
IL234234B (en) 2020-06-30
KR102020255B1 (ko) 2019-09-10
MX350248B (es) 2017-08-31
CN104321344B (zh) 2017-11-21
EP2831111A1 (en) 2015-02-04
MX2014011171A (es) 2015-03-06
HRP20190817T1 (hr) 2019-06-28
PH12014502179B1 (en) 2014-12-10
AU2013241769B2 (en) 2017-05-11
EP2831111B1 (en) 2019-03-20
BR112014023415A2 (pt) 2017-07-11
LT2831111T (lt) 2019-05-10
US20170107281A1 (en) 2017-04-20
PL2831111T3 (pl) 2019-09-30
KR20140146606A (ko) 2014-12-26

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