TR201902686T4 - Aurora A kinaz inhibitörü. - Google Patents

Aurora A kinaz inhibitörü. Download PDF

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Publication number
TR201902686T4
TR201902686T4 TR2019/02686T TR201902686T TR201902686T4 TR 201902686 T4 TR201902686 T4 TR 201902686T4 TR 2019/02686 T TR2019/02686 T TR 2019/02686T TR 201902686 T TR201902686 T TR 201902686T TR 201902686 T4 TR201902686 T4 TR 201902686T4
Authority
TR
Turkey
Prior art keywords
methyl
fluoro
aurora
kinase inhibitor
pyrazol
Prior art date
Application number
TR2019/02686T
Other languages
English (en)
Inventor
Robert Henry James
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TR201902686T4 publication Critical patent/TR201902686T4/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Bu buluş (2S,4S)-l-[(3-kloro-2-floro-fenil)metil]-4-[[3-floro-6-[(5-metil-lH-pirazol-3-il)amino]-2-piridil]metil]-2-metil- piperidin-4-karboksilik asit (1. Formül) ve (2R,4R)-l-[(3-kloro-2-floro-fenil)metil]-4-[[3-floro-6- [(5-metil-lH-pirazol-3-il)amino]-2-piridil]metil]-2-metil- piperidin-4-karboksilik asit (2. Formül) veya bunların farmasötik olarak kabul edilebilir bir tuzundan oluşan gruptan seçilen, Aurora A?yı inhibe eden ve dolayısıyla kanser tedavisinde yararlı olabilen bir aminopiridin bileşiği sağlar.
TR2019/02686T 2014-11-14 2015-11-06 Aurora A kinaz inhibitörü. TR201902686T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462079742P 2014-11-14 2014-11-14

Publications (1)

Publication Number Publication Date
TR201902686T4 true TR201902686T4 (tr) 2019-03-21

Family

ID=54697647

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/02686T TR201902686T4 (tr) 2014-11-14 2015-11-06 Aurora A kinaz inhibitörü.

Country Status (41)

Country Link
US (2) US9637474B2 (tr)
EP (2) EP3473619B8 (tr)
JP (1) JP6159029B2 (tr)
KR (1) KR101930182B1 (tr)
CN (1) CN107108567B (tr)
AR (1) AR102463A1 (tr)
AU (1) AU2015347043B2 (tr)
BR (1) BR112017007239B1 (tr)
CA (1) CA2963473C (tr)
CL (1) CL2017001209A1 (tr)
CO (1) CO2017004784A2 (tr)
CR (1) CR20170158A (tr)
CY (2) CY1121334T1 (tr)
DK (2) DK3473619T3 (tr)
DO (1) DOP2017000111A (tr)
EA (1) EA032102B1 (tr)
EC (1) ECSP17029203A (tr)
ES (2) ES2716732T3 (tr)
HR (2) HRP20190324T1 (tr)
HU (2) HUE043759T2 (tr)
IL (1) IL251406B (tr)
JO (1) JO3488B1 (tr)
LT (2) LT3473619T (tr)
ME (1) ME03325B (tr)
MX (1) MX2017006275A (tr)
MY (1) MY188313A (tr)
NZ (1) NZ730771A (tr)
PE (1) PE20170898A1 (tr)
PH (1) PH12017500881B1 (tr)
PL (1) PL3218366T3 (tr)
PT (2) PT3218366T (tr)
RS (2) RS60999B1 (tr)
SG (1) SG11201703394RA (tr)
SI (2) SI3473619T1 (tr)
SV (1) SV2017005418A (tr)
TN (1) TN2017000116A1 (tr)
TR (1) TR201902686T4 (tr)
TW (1) TWI693218B (tr)
UA (1) UA117983C2 (tr)
WO (1) WO2016077161A1 (tr)
ZA (1) ZA201702199B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210236475A1 (en) * 2018-05-29 2021-08-05 Taiho Pharmaceutical Co., Ltd. Antitumor agent and method for tumor therapy
US20220000855A1 (en) * 2018-11-30 2022-01-06 Eli Lilly And Company An aurora a kinase inhibitor for use in the treatment of neuroblastoma
CN112239465A (zh) 2019-07-16 2021-01-19 微境生物医药科技(上海)有限公司 极光激酶抑制剂及其用途
CN112898292A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
TWI785474B (zh) * 2020-01-22 2022-12-01 大陸商北京加科思新藥研發有限公司 用作選擇性Aurora A抑制劑的新型雜環化合物
AU2022280845A1 (en) 2021-05-24 2023-12-14 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound, preparation method therefor, and application thereof in medicines
CN117836285A (zh) * 2021-07-28 2024-04-05 北京加科思新药研发有限公司 Aurora a选择性抑制剂的多晶型及其用途
WO2023196887A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company Method of treatment including kras g12c inhibitors and aurora a inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1956982A (zh) * 2004-05-21 2007-05-02 万有制药株式会社 具有氨基噻唑骨架的Cdk4、6选择性抑制剂
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
WO2009104802A1 (en) * 2008-02-22 2009-08-27 Banyu Pharmaceutical Co., Ltd. Novel aminopyridine derivatives having aurora a selective inhibitory action
US8367690B2 (en) * 2009-03-24 2013-02-05 Vertex Pharmaceuticals Inc. Aminopyridine derivatives having aurora a selective inhibitory action
TWI485146B (zh) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof

Also Published As

Publication number Publication date
SG11201703394RA (en) 2017-05-30
BR112017007239A2 (pt) 2017-12-19
CY1123592T1 (el) 2022-03-24
CA2963473A1 (en) 2016-05-19
EP3473619B8 (en) 2020-11-04
EP3473619B1 (en) 2020-09-09
PT3218366T (pt) 2019-04-01
MX2017006275A (es) 2017-08-14
LT3473619T (lt) 2020-11-10
AU2015347043A1 (en) 2017-05-04
JO3488B1 (ar) 2020-07-05
TN2017000116A1 (en) 2018-07-04
HRP20190324T1 (hr) 2019-04-19
LT3218366T (lt) 2019-04-10
EP3218366B1 (en) 2019-01-09
HRP20201681T1 (hr) 2020-12-25
BR112017007239B1 (pt) 2023-01-31
ES2716732T3 (es) 2019-06-14
ME03325B (me) 2019-10-20
SI3218366T1 (sl) 2019-02-28
DK3218366T3 (en) 2019-04-01
UA117983C2 (uk) 2018-10-25
PE20170898A1 (es) 2017-07-12
CY1121334T1 (el) 2020-05-29
MY188313A (en) 2021-11-27
AU2015347043B2 (en) 2018-03-22
RS58347B1 (sr) 2019-03-29
RS60999B1 (sr) 2020-11-30
JP6159029B2 (ja) 2017-07-05
CL2017001209A1 (es) 2018-01-12
US20160137628A1 (en) 2016-05-19
AR102463A1 (es) 2017-03-01
SI3473619T1 (sl) 2020-10-30
CA2963473C (en) 2018-12-18
PH12017500881A1 (en) 2017-11-06
IL251406A0 (en) 2017-05-29
EP3473619A1 (en) 2019-04-24
CR20170158A (es) 2017-06-21
PL3218366T3 (pl) 2019-06-28
EA201790838A1 (ru) 2017-12-29
TWI693218B (zh) 2020-05-11
US9637474B2 (en) 2017-05-02
NZ730771A (en) 2018-07-27
ECSP17029203A (es) 2018-01-31
ZA201702199B (en) 2018-12-19
PH12017500881B1 (en) 2017-11-06
HUE051530T2 (hu) 2021-03-01
SV2017005418A (es) 2018-10-09
CO2017004784A2 (es) 2017-08-31
DOP2017000111A (es) 2017-06-15
JP2016539942A (ja) 2016-12-22
CN107108567A (zh) 2017-08-29
EA032102B1 (ru) 2019-04-30
DK3473619T3 (da) 2020-09-21
PT3473619T (pt) 2020-11-11
CN107108567B (zh) 2020-01-10
WO2016077161A1 (en) 2016-05-19
EP3218366A1 (en) 2017-09-20
HUE043759T2 (hu) 2019-09-30
IL251406B (en) 2019-08-29
US10010540B2 (en) 2018-07-03
US20170119751A1 (en) 2017-05-04
KR20170066623A (ko) 2017-06-14
KR101930182B1 (ko) 2018-12-17
TW201629038A (zh) 2016-08-16
ES2826448T3 (es) 2021-05-18

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