PT3473619T - Inibidor da cinase aurora a - Google Patents

Inibidor da cinase aurora a

Info

Publication number
PT3473619T
PT3473619T PT182043893T PT18204389T PT3473619T PT 3473619 T PT3473619 T PT 3473619T PT 182043893 T PT182043893 T PT 182043893T PT 18204389 T PT18204389 T PT 18204389T PT 3473619 T PT3473619 T PT 3473619T
Authority
PT
Portugal
Prior art keywords
aurora
kinase inhibitor
kinase
inhibitor
Prior art date
Application number
PT182043893T
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT3473619T publication Critical patent/PT3473619T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT182043893T 2014-11-14 2015-11-06 Inibidor da cinase aurora a PT3473619T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462079742P 2014-11-14 2014-11-14

Publications (1)

Publication Number Publication Date
PT3473619T true PT3473619T (pt) 2020-11-11

Family

ID=54697647

Family Applications (2)

Application Number Title Priority Date Filing Date
PT15798602T PT3218366T (pt) 2014-11-14 2015-11-06 Inibidor da cinase aurora a
PT182043893T PT3473619T (pt) 2014-11-14 2015-11-06 Inibidor da cinase aurora a

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT15798602T PT3218366T (pt) 2014-11-14 2015-11-06 Inibidor da cinase aurora a

Country Status (41)

Country Link
US (2) US9637474B2 (pt)
EP (2) EP3218366B1 (pt)
JP (1) JP6159029B2 (pt)
KR (1) KR101930182B1 (pt)
CN (1) CN107108567B (pt)
AR (1) AR102463A1 (pt)
AU (1) AU2015347043B2 (pt)
BR (1) BR112017007239B1 (pt)
CA (1) CA2963473C (pt)
CL (1) CL2017001209A1 (pt)
CO (1) CO2017004784A2 (pt)
CR (1) CR20170158A (pt)
CY (2) CY1121334T1 (pt)
DK (2) DK3473619T3 (pt)
DO (1) DOP2017000111A (pt)
EA (1) EA032102B1 (pt)
EC (1) ECSP17029203A (pt)
ES (2) ES2826448T3 (pt)
HR (2) HRP20190324T1 (pt)
HU (2) HUE043759T2 (pt)
IL (1) IL251406B (pt)
JO (1) JO3488B1 (pt)
LT (2) LT3473619T (pt)
ME (1) ME03325B (pt)
MX (1) MX2017006275A (pt)
MY (1) MY188313A (pt)
NZ (1) NZ730771A (pt)
PE (1) PE20170898A1 (pt)
PH (1) PH12017500881B1 (pt)
PL (1) PL3218366T3 (pt)
PT (2) PT3218366T (pt)
RS (2) RS58347B1 (pt)
SG (1) SG11201703394RA (pt)
SI (2) SI3218366T1 (pt)
SV (1) SV2017005418A (pt)
TN (1) TN2017000116A1 (pt)
TR (1) TR201902686T4 (pt)
TW (1) TWI693218B (pt)
UA (1) UA117983C2 (pt)
WO (1) WO2016077161A1 (pt)
ZA (1) ZA201702199B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3804721A4 (en) * 2018-05-29 2022-03-16 Taiho Pharmaceutical Co., Ltd. ANTITUMORS AGENTS AND METHODS FOR TUMOR THERAPY
EP3886855A1 (en) * 2018-11-30 2021-10-06 Eli Lilly And Company An aurora a kinase inhibitor for use in the treatment of neuroblastoma
CN112239465A (zh) * 2019-07-16 2021-01-19 微境生物医药科技(上海)有限公司 极光激酶抑制剂及其用途
CN112898292A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
TWI785474B (zh) * 2020-01-22 2022-12-01 大陸商北京加科思新藥研發有限公司 用作選擇性Aurora A抑制劑的新型雜環化合物
AU2022280845A1 (en) 2021-05-24 2023-12-14 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound, preparation method therefor, and application thereof in medicines
CN117836285A (zh) * 2021-07-28 2024-04-05 北京加科思新药研发有限公司 Aurora a选择性抑制剂的多晶型及其用途
WO2023196887A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company Method of treatment including kras g12c inhibitors and aurora a inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709475B2 (en) * 2004-05-21 2010-05-04 Banyu Pharmaceutical Co., Ltd. Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton
JP2008081492A (ja) * 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
EP2254888B1 (en) * 2008-02-22 2014-12-24 Msd K.K. Novel aminopyridine derivatives having aurora a selective inhibitory action
AU2010229140A1 (en) * 2009-03-24 2011-11-10 Msd K.K. Novel aminopyridine derivatives having Aurora A selective inhibitory action
TWI485146B (zh) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof

Also Published As

Publication number Publication date
JP2016539942A (ja) 2016-12-22
CN107108567A (zh) 2017-08-29
PH12017500881A1 (en) 2017-11-06
PH12017500881B1 (en) 2017-11-06
US20160137628A1 (en) 2016-05-19
CR20170158A (es) 2017-06-21
CL2017001209A1 (es) 2018-01-12
PE20170898A1 (es) 2017-07-12
EP3218366B1 (en) 2019-01-09
SI3473619T1 (sl) 2020-10-30
ECSP17029203A (es) 2018-01-31
ME03325B (me) 2019-10-20
CA2963473C (en) 2018-12-18
DOP2017000111A (es) 2017-06-15
CY1121334T1 (el) 2020-05-29
ES2716732T3 (es) 2019-06-14
US10010540B2 (en) 2018-07-03
DK3218366T3 (en) 2019-04-01
NZ730771A (en) 2018-07-27
EP3473619B8 (en) 2020-11-04
KR20170066623A (ko) 2017-06-14
TN2017000116A1 (en) 2018-07-04
HUE051530T2 (hu) 2021-03-01
SG11201703394RA (en) 2017-05-30
IL251406B (en) 2019-08-29
LT3473619T (lt) 2020-11-10
EA032102B1 (ru) 2019-04-30
HRP20201681T1 (hr) 2020-12-25
SI3218366T1 (sl) 2019-02-28
IL251406A0 (en) 2017-05-29
MY188313A (en) 2021-11-27
PL3218366T3 (pl) 2019-06-28
EP3218366A1 (en) 2017-09-20
EP3473619B1 (en) 2020-09-09
TW201629038A (zh) 2016-08-16
LT3218366T (lt) 2019-04-10
RS58347B1 (sr) 2019-03-29
TR201902686T4 (tr) 2019-03-21
ES2826448T3 (es) 2021-05-18
MX2017006275A (es) 2017-08-14
RS60999B1 (sr) 2020-11-30
HRP20190324T1 (hr) 2019-04-19
CY1123592T1 (el) 2022-03-24
TWI693218B (zh) 2020-05-11
AU2015347043B2 (en) 2018-03-22
AU2015347043A1 (en) 2017-05-04
WO2016077161A1 (en) 2016-05-19
US9637474B2 (en) 2017-05-02
CN107108567B (zh) 2020-01-10
SV2017005418A (es) 2018-10-09
ZA201702199B (en) 2018-12-19
CA2963473A1 (en) 2016-05-19
EP3473619A1 (en) 2019-04-24
CO2017004784A2 (es) 2017-08-31
DK3473619T3 (da) 2020-09-21
BR112017007239B1 (pt) 2023-01-31
KR101930182B1 (ko) 2018-12-17
US20170119751A1 (en) 2017-05-04
UA117983C2 (uk) 2018-10-25
AR102463A1 (es) 2017-03-01
EA201790838A1 (ru) 2017-12-29
JO3488B1 (ar) 2020-07-05
HUE043759T2 (hu) 2019-09-30
JP6159029B2 (ja) 2017-07-05
PT3218366T (pt) 2019-04-01
BR112017007239A2 (pt) 2017-12-19

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