UA117983C2 - Інгібітор кінази aurora a - Google Patents

Інгібітор кінази aurora a

Info

Publication number
UA117983C2
UA117983C2 UAA201704577A UAA201704577A UA117983C2 UA 117983 C2 UA117983 C2 UA 117983C2 UA A201704577 A UAA201704577 A UA A201704577A UA A201704577 A UAA201704577 A UA A201704577A UA 117983 C2 UA117983 C2 UA 117983C2
Authority
UA
Ukraine
Prior art keywords
methyl
fluoro
aurora
kinase inhibitor
pyrazol
Prior art date
Application number
UAA201704577A
Other languages
English (en)
Inventor
Джеймз Роберт Хенрі
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA117983C2 publication Critical patent/UA117983C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Цим винаходом запропонована амінопіридинова сполука, вибрана з групи, яку складають (2S,4S)-1-[(3-хлор-2-фторфеніл)метил]-4-[[3-фтор-6-[(5-метил-1Н-піразол-3-іл)аміно]-2-піридил]метил]-2-метилпіперидин-4-карбонова кислота і (2R,4R)-1-[(3-хлор-2-фторфеніл)метил]-4-[[3-фтор-6-[(5-метил-1Н-піразол-3-іл)аміно]-2-піридил]метил]-2-метилпіперидин-4-карбонова кислота або її фармацевтично прийнятна сіль, яка пригнічує кіназу Aurora А і тому може бути корисною для лікування раку.
UAA201704577A 2014-11-14 2015-11-06 Інгібітор кінази aurora a UA117983C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462079742P 2014-11-14 2014-11-14
PCT/US2015/059390 WO2016077161A1 (en) 2014-11-14 2015-11-06 Aurora a kinase inhibitor

Publications (1)

Publication Number Publication Date
UA117983C2 true UA117983C2 (uk) 2018-10-25

Family

ID=54697647

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201704577A UA117983C2 (uk) 2014-11-14 2015-11-06 Інгібітор кінази aurora a

Country Status (41)

Country Link
US (2) US9637474B2 (uk)
EP (2) EP3218366B1 (uk)
JP (1) JP6159029B2 (uk)
KR (1) KR101930182B1 (uk)
CN (1) CN107108567B (uk)
AR (1) AR102463A1 (uk)
AU (1) AU2015347043B2 (uk)
BR (1) BR112017007239B1 (uk)
CA (1) CA2963473C (uk)
CL (1) CL2017001209A1 (uk)
CO (1) CO2017004784A2 (uk)
CR (1) CR20170158A (uk)
CY (2) CY1121334T1 (uk)
DK (2) DK3218366T3 (uk)
DO (1) DOP2017000111A (uk)
EA (1) EA032102B1 (uk)
EC (1) ECSP17029203A (uk)
ES (2) ES2716732T3 (uk)
HR (2) HRP20190324T1 (uk)
HU (2) HUE043759T2 (uk)
IL (1) IL251406B (uk)
JO (1) JO3488B1 (uk)
LT (2) LT3218366T (uk)
ME (1) ME03325B (uk)
MX (1) MX2017006275A (uk)
MY (1) MY188313A (uk)
NZ (1) NZ730771A (uk)
PE (1) PE20170898A1 (uk)
PH (1) PH12017500881B1 (uk)
PL (1) PL3218366T3 (uk)
PT (2) PT3473619T (uk)
RS (2) RS58347B1 (uk)
SG (1) SG11201703394RA (uk)
SI (2) SI3218366T1 (uk)
SV (1) SV2017005418A (uk)
TN (1) TN2017000116A1 (uk)
TR (1) TR201902686T4 (uk)
TW (1) TWI693218B (uk)
UA (1) UA117983C2 (uk)
WO (1) WO2016077161A1 (uk)
ZA (1) ZA201702199B (uk)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA52793A (fr) * 2018-05-29 2021-04-14 Taiho Pharmaceutical Co Ltd Agent antitumoral et méthode de traitement d'une tumeur
US20220000855A1 (en) * 2018-11-30 2022-01-06 Eli Lilly And Company An aurora a kinase inhibitor for use in the treatment of neuroblastoma
CN112239465A (zh) 2019-07-16 2021-01-19 微境生物医药科技(上海)有限公司 极光激酶抑制剂及其用途
CN112898292A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
TWI785474B (zh) * 2020-01-22 2022-12-01 大陸商北京加科思新藥研發有限公司 用作選擇性Aurora A抑制劑的新型雜環化合物
KR20240012437A (ko) 2021-05-24 2024-01-29 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 질소 함유 헤테로사이클릭 화합물, 이의 제조 방법 및 의학에서 이의 응용
TW202321215A (zh) * 2021-07-28 2023-06-01 大陸商北京加科思新藥研發有限公司 Aurora a 選擇性抑制劑的多晶型及其用途
WO2023196887A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company Method of treatment including kras g12c inhibitors and aurora a inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005264213A1 (en) * 2004-05-21 2006-01-26 Msd K.K. Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton
KR20070072562A (ko) * 2004-10-29 2007-07-04 반유 세이야꾸 가부시끼가이샤 오로라 ａ 선택적 억제 활성을 갖는 신규한 아미노피리딘유도체
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US8519136B2 (en) * 2008-02-22 2013-08-27 Msd K.K. Aminopyridine derivatives having aurora a selective inhibitory action
AU2010229140A1 (en) * 2009-03-24 2011-11-10 Msd K.K. Novel aminopyridine derivatives having Aurora A selective inhibitory action
TWI485146B (zh) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof

Also Published As

Publication number Publication date
CN107108567A (zh) 2017-08-29
AU2015347043A1 (en) 2017-05-04
PH12017500881A1 (en) 2017-11-06
TR201902686T4 (tr) 2019-03-21
LT3218366T (lt) 2019-04-10
HUE051530T2 (hu) 2021-03-01
EP3218366B1 (en) 2019-01-09
CY1121334T1 (el) 2020-05-29
JP6159029B2 (ja) 2017-07-05
ES2826448T3 (es) 2021-05-18
CY1123592T1 (el) 2022-03-24
EP3473619B1 (en) 2020-09-09
AR102463A1 (es) 2017-03-01
HRP20190324T1 (hr) 2019-04-19
DOP2017000111A (es) 2017-06-15
US9637474B2 (en) 2017-05-02
TW201629038A (zh) 2016-08-16
DK3473619T3 (da) 2020-09-21
HRP20201681T1 (hr) 2020-12-25
CL2017001209A1 (es) 2018-01-12
PT3218366T (pt) 2019-04-01
JP2016539942A (ja) 2016-12-22
NZ730771A (en) 2018-07-27
ES2716732T3 (es) 2019-06-14
RS58347B1 (sr) 2019-03-29
SI3218366T1 (sl) 2019-02-28
PT3473619T (pt) 2020-11-11
ZA201702199B (en) 2018-12-19
EP3218366A1 (en) 2017-09-20
WO2016077161A1 (en) 2016-05-19
PE20170898A1 (es) 2017-07-12
US20170119751A1 (en) 2017-05-04
PL3218366T3 (pl) 2019-06-28
BR112017007239B1 (pt) 2023-01-31
TWI693218B (zh) 2020-05-11
CN107108567B (zh) 2020-01-10
HUE043759T2 (hu) 2019-09-30
AU2015347043B2 (en) 2018-03-22
LT3473619T (lt) 2020-11-10
SG11201703394RA (en) 2017-05-30
CO2017004784A2 (es) 2017-08-31
KR20170066623A (ko) 2017-06-14
EA032102B1 (ru) 2019-04-30
PH12017500881B1 (en) 2017-11-06
MX2017006275A (es) 2017-08-14
SI3473619T1 (sl) 2020-10-30
SV2017005418A (es) 2018-10-09
IL251406B (en) 2019-08-29
EP3473619B8 (en) 2020-11-04
US20160137628A1 (en) 2016-05-19
EP3473619A1 (en) 2019-04-24
EA201790838A1 (ru) 2017-12-29
CR20170158A (es) 2017-06-21
ME03325B (me) 2019-10-20
US10010540B2 (en) 2018-07-03
MY188313A (en) 2021-11-27
DK3218366T3 (en) 2019-04-01
IL251406A0 (en) 2017-05-29
JO3488B1 (ar) 2020-07-05
CA2963473C (en) 2018-12-18
RS60999B1 (sr) 2020-11-30
TN2017000116A1 (en) 2018-07-04
BR112017007239A2 (pt) 2017-12-19
CA2963473A1 (en) 2016-05-19
ECSP17029203A (es) 2018-01-31
KR101930182B1 (ko) 2018-12-17

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