TR201818966T4 - İyon değişim kromatografisi girdi optimizasyonunun açıklaması. - Google Patents

İyon değişim kromatografisi girdi optimizasyonunun açıklaması. Download PDF

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Publication number
TR201818966T4
TR201818966T4 TR2018/18966T TR201818966T TR201818966T4 TR 201818966 T4 TR201818966 T4 TR 201818966T4 TR 2018/18966 T TR2018/18966 T TR 2018/18966T TR 201818966 T TR201818966 T TR 201818966T TR 201818966 T4 TR201818966 T4 TR 201818966T4
Authority
TR
Turkey
Prior art keywords
explanation
ion exchange
exchange chromatography
input optimization
present
Prior art date
Application number
TR2018/18966T
Other languages
English (en)
Turkish (tr)
Inventor
Mcdonald Daniel
Patapoff Thomas
Wang Yajun
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TR201818966T4 publication Critical patent/TR201818966T4/tr

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/86Signal analysis
    • G01N30/8658Optimising operation parameters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/34Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Confectionery (AREA)
TR2018/18966T 2013-07-12 2014-07-11 İyon değişim kromatografisi girdi optimizasyonunun açıklaması. TR201818966T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12

Publications (1)

Publication Number Publication Date
TR201818966T4 true TR201818966T4 (tr) 2019-01-21

Family

ID=51257626

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/18966T TR201818966T4 (tr) 2013-07-12 2014-07-11 İyon değişim kromatografisi girdi optimizasyonunun açıklaması.

Country Status (18)

Country Link
US (2) US10274466B2 (https=)
EP (2) EP3019516B1 (https=)
JP (2) JP6462681B2 (https=)
KR (1) KR102251127B1 (https=)
CN (1) CN105377873B (https=)
AU (1) AU2014287044B2 (https=)
BR (1) BR112016000231A8 (https=)
CA (1) CA2918052A1 (https=)
ES (1) ES2705700T3 (https=)
HR (1) HRP20190071T1 (https=)
IL (1) IL243305B (https=)
MX (1) MX368107B (https=)
PL (1) PL3019516T3 (https=)
RU (1) RU2016104542A (https=)
SG (1) SG11201600221YA (https=)
SI (1) SI3019516T1 (https=)
TR (1) TR201818966T4 (https=)
WO (1) WO2015006686A1 (https=)

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US11460455B2 (en) 2014-11-12 2022-10-04 Cytiva Sweden Ab Method and system for determining the influence of experimental parameters on a liquid chromatography protocol
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
AU2019246983B2 (en) * 2018-04-02 2025-12-18 Amgen Inc. Erenumab compositions and uses thereof
WO2020010304A2 (en) * 2018-07-05 2020-01-09 Ovation Diagnostics Llc BCl-2 Antibodies and Immunoassay for Diagnosis of Cancer
KR20200080748A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
WO2024261724A1 (en) * 2023-06-23 2024-12-26 Lupin Limited Ion-exchange chromatography for separation and analysis of charge variants

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Also Published As

Publication number Publication date
WO2015006686A1 (en) 2015-01-15
SG11201600221YA (en) 2016-02-26
CN105377873A (zh) 2016-03-02
JP2019090818A (ja) 2019-06-13
HRP20190071T1 (hr) 2019-02-22
AU2014287044B2 (en) 2020-02-06
HK1222183A1 (zh) 2017-06-23
EP3019516A1 (en) 2016-05-18
US20190310234A1 (en) 2019-10-10
JP6462681B2 (ja) 2019-01-30
CN105377873B (zh) 2021-03-30
IL243305B (en) 2019-09-26
ES2705700T3 (es) 2019-03-26
BR112016000231A8 (pt) 2019-12-31
JP2016529489A (ja) 2016-09-23
PL3019516T3 (pl) 2019-04-30
AU2014287044A1 (en) 2016-02-11
KR20160030251A (ko) 2016-03-16
EP3019516B1 (en) 2018-11-14
IL243305A0 (en) 2016-03-31
US10921297B2 (en) 2021-02-16
RU2016104542A (ru) 2017-08-17
MX368107B (es) 2019-09-18
US10274466B2 (en) 2019-04-30
WO2015006686A8 (en) 2018-10-04
EP3536699A1 (en) 2019-09-11
US20160161455A1 (en) 2016-06-09
MX2016000181A (es) 2016-03-09
CA2918052A1 (en) 2015-01-15
KR102251127B1 (ko) 2021-05-11
SI3019516T1 (sl) 2019-02-28

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