MX2015011443A - Proteínas de fusión y métodos para identificar compuestos inhibidores del bromodomino. - Google Patents

Proteínas de fusión y métodos para identificar compuestos inhibidores del bromodomino.

Info

Publication number
MX2015011443A
MX2015011443A MX2015011443A MX2015011443A MX2015011443A MX 2015011443 A MX2015011443 A MX 2015011443A MX 2015011443 A MX2015011443 A MX 2015011443A MX 2015011443 A MX2015011443 A MX 2015011443A MX 2015011443 A MX2015011443 A MX 2015011443A
Authority
MX
Mexico
Prior art keywords
fusion proteins
identifying
methods
inhibiting compounds
bromodomain inhibiting
Prior art date
Application number
MX2015011443A
Other languages
English (en)
Inventor
Hon-Ren Huang
Robert J Sims Iii
Steven Frank Bellon
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of MX2015011443A publication Critical patent/MX2015011443A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a proteínas de fusión que comprenden al menos un módulo de unión a la cromatina y al menos un módulo indicador, donde una pluralidad de proteínas de fusión son capaces de formar focos, y métodos asociados para la identificación de compuestos que inhiben al bromodominio.
MX2015011443A 2013-03-15 2014-03-14 Proteínas de fusión y métodos para identificar compuestos inhibidores del bromodomino. MX2015011443A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798644P 2013-03-15 2013-03-15
US201361902690P 2013-11-11 2013-11-11
PCT/US2014/028650 WO2014144303A1 (en) 2013-03-15 2014-03-14 Fusion proteins and methods for identifying bromodomain inhibiting compounds

Publications (1)

Publication Number Publication Date
MX2015011443A true MX2015011443A (es) 2016-05-26

Family

ID=50588893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011443A MX2015011443A (es) 2013-03-15 2014-03-14 Proteínas de fusión y métodos para identificar compuestos inhibidores del bromodomino.

Country Status (11)

Country Link
US (2) US20160002306A1 (es)
EP (1) EP2970414B1 (es)
JP (1) JP6408555B2 (es)
KR (1) KR20150132222A (es)
CN (1) CN105555798A (es)
BR (1) BR112015023119A2 (es)
CA (1) CA2903547A1 (es)
HK (1) HK1218422A1 (es)
MX (1) MX2015011443A (es)
RU (1) RU2015144279A (es)
WO (1) WO2014144303A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3075743A1 (en) * 2015-03-30 2016-10-05 Universität Stuttgart Isolation of nucleosomes having multiple-modified histone protein octamers
WO2020132260A1 (en) * 2018-12-21 2020-06-25 Ptm Bio Llc Reagents and methods for detecting protein lysine lactylation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060230465A1 (en) * 2004-09-10 2006-10-12 Andreas Winterpacht K203 gene and protein
JP5283104B2 (ja) * 2007-01-10 2013-09-04 独立行政法人理化学研究所 アセチル化及び脱アセチル化の蛍光可視化検出方法

Also Published As

Publication number Publication date
KR20150132222A (ko) 2015-11-25
HK1218422A1 (zh) 2017-02-17
CA2903547A1 (en) 2014-09-18
CN105555798A (zh) 2016-05-04
US20190048048A1 (en) 2019-02-14
US20160002306A1 (en) 2016-01-07
JP6408555B2 (ja) 2018-10-17
BR112015023119A2 (pt) 2017-11-21
JP2016512847A (ja) 2016-05-09
RU2015144279A (ru) 2017-04-19
WO2014144303A1 (en) 2014-09-18
EP2970414A1 (en) 2016-01-20
EP2970414B1 (en) 2018-10-31

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