TR201809630T4 - Çok değerlikli siyalik asit türevleri. - Google Patents
Çok değerlikli siyalik asit türevleri. Download PDFInfo
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- TR201809630T4 TR201809630T4 TR2018/09630T TR201809630T TR201809630T4 TR 201809630 T4 TR201809630 T4 TR 201809630T4 TR 2018/09630 T TR2018/09630 T TR 2018/09630T TR 201809630 T TR201809630 T TR 201809630T TR 201809630 T4 TR201809630 T4 TR 201809630T4
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- Prior art keywords
- sialic acid
- acid derivative
- formula
- groups
- pharmaceutical composition
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- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title claims abstract description 79
- 208000015181 infectious disease Diseases 0.000 claims abstract description 39
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- 210000004027 cell Anatomy 0.000 claims description 54
- 150000001875 compounds Chemical class 0.000 claims description 49
- 239000008194 pharmaceutical composition Substances 0.000 claims description 48
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- 239000007983 Tris buffer Substances 0.000 claims description 25
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 24
- 241000700605 Viruses Species 0.000 claims description 22
- 150000001412 amines Chemical class 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 229910001868 water Inorganic materials 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 13
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 4
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- 125000005629 sialic acid group Chemical group 0.000 abstract description 28
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- RWWYLEGWBNMMLJ-YSOARWBDSA-N remdesivir Chemical compound NC1=NC=NN2C1=CC=C2[C@]1([C@@H]([C@@H]([C@H](O1)CO[P@](=O)(OC1=CC=CC=C1)N[C@H](C(=O)OCC(CC)CC)C)O)O)C#N RWWYLEGWBNMMLJ-YSOARWBDSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical compound [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000024058 virion binding Effects 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1350991 | 2013-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201809630T4 true TR201809630T4 (tr) | 2018-07-23 |
Family
ID=51454687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/09630T TR201809630T4 (tr) | 2013-08-28 | 2014-08-28 | Çok değerlikli siyalik asit türevleri. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10011628B2 (enExample) |
| EP (1) | EP3039029B1 (enExample) |
| JP (1) | JP6360895B2 (enExample) |
| KR (1) | KR20160073372A (enExample) |
| CN (1) | CN105722849B (enExample) |
| AU (1) | AU2014314212B2 (enExample) |
| CA (1) | CA2921634A1 (enExample) |
| ES (1) | ES2677219T3 (enExample) |
| IL (1) | IL244246B (enExample) |
| MX (1) | MX2016002578A (enExample) |
| PL (1) | PL3039029T3 (enExample) |
| TR (1) | TR201809630T4 (enExample) |
| WO (1) | WO2015028548A1 (enExample) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904289D0 (sv) | 1999-11-26 | 1999-11-26 | Niklas Arnberg | Method and camposition for the treatment of adenovairal ocular infections |
| US20070020620A1 (en) | 2005-07-14 | 2007-01-25 | Finn M G | Compositions and methods for coupling a plurality of compounds to a scaffold |
| US20080194801A1 (en) * | 2007-02-14 | 2008-08-14 | Swanson Basil I | Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses |
| CA2765919C (en) | 2009-07-07 | 2017-07-18 | Adenovir Pharma Ab | New antiviral compounds useful for the treatment or the prevention of epidemic keratoconjonctivitis |
| KR101217685B1 (ko) | 2010-05-28 | 2013-01-02 | 서강대학교산학협력단 | 서로 다른 실릴기로 보호된 알킨 그룹을 갖는 삼중연결고리 화합물, 이의 제조방법 및 응용 |
| WO2011158068A1 (en) | 2010-06-18 | 2011-12-22 | Centre National De La Recherche Scientifique (Cnrs) | Non covalent molecular structure, device comprising the same and its use for detection of lectin |
-
2014
- 2014-08-28 PL PL14758353T patent/PL3039029T3/pl unknown
- 2014-08-28 CN CN201480047068.3A patent/CN105722849B/zh not_active Expired - Fee Related
- 2014-08-28 EP EP14758353.8A patent/EP3039029B1/en not_active Not-in-force
- 2014-08-28 MX MX2016002578A patent/MX2016002578A/es unknown
- 2014-08-28 WO PCT/EP2014/068252 patent/WO2015028548A1/en not_active Ceased
- 2014-08-28 ES ES14758353.8T patent/ES2677219T3/es active Active
- 2014-08-28 TR TR2018/09630T patent/TR201809630T4/tr unknown
- 2014-08-28 JP JP2016537292A patent/JP6360895B2/ja not_active Expired - Fee Related
- 2014-08-28 CA CA2921634A patent/CA2921634A1/en not_active Abandoned
- 2014-08-28 KR KR1020167007981A patent/KR20160073372A/ko not_active Ceased
- 2014-08-28 AU AU2014314212A patent/AU2014314212B2/en not_active Ceased
- 2014-08-28 US US14/914,988 patent/US10011628B2/en not_active Expired - Fee Related
-
2016
- 2016-02-23 IL IL244246A patent/IL244246B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US10011628B2 (en) | 2018-07-03 |
| KR20160073372A (ko) | 2016-06-24 |
| EP3039029A1 (en) | 2016-07-06 |
| CA2921634A1 (en) | 2015-03-05 |
| EP3039029B1 (en) | 2018-04-11 |
| CN105722849B (zh) | 2019-01-29 |
| AU2014314212B2 (en) | 2018-03-01 |
| JP2016529269A (ja) | 2016-09-23 |
| US20160207955A1 (en) | 2016-07-21 |
| CN105722849A (zh) | 2016-06-29 |
| IL244246B (en) | 2019-02-28 |
| PL3039029T3 (pl) | 2018-10-31 |
| IL244246A0 (en) | 2016-04-21 |
| WO2015028548A1 (en) | 2015-03-05 |
| MX2016002578A (es) | 2016-09-08 |
| JP6360895B2 (ja) | 2018-07-18 |
| AU2014314212A1 (en) | 2016-03-10 |
| ES2677219T3 (es) | 2018-07-31 |
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