TR200103581T2 - Graft versus host hastalığı tedavisinde CD20' ye karşı antikorların kullanımı. - Google Patents
Graft versus host hastalığı tedavisinde CD20' ye karşı antikorların kullanımı.Info
- Publication number
- TR200103581T2 TR200103581T2 TR2001/03581T TR200103581T TR200103581T2 TR 200103581 T2 TR200103581 T2 TR 200103581T2 TR 2001/03581 T TR2001/03581 T TR 2001/03581T TR 200103581 T TR200103581 T TR 200103581T TR 200103581 T2 TR200103581 T2 TR 200103581T2
- Authority
- TR
- Turkey
- Prior art keywords
- treatment
- antibodies against
- versus host
- graft versus
- host disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Harici yüzey antijenleri ile dönüstürülmüs T lenfositler alan hastalarda graft versus host (GVH) hastaligi tedavisine mahsus bilesimlerin hazirlanmasi için normal insan T lenfositlerinde mevcut olmayan harici yüzey antijenlerine karsi antikorlarin kullanimi tarif edilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001299A ITMI991299A1 (it) | 1999-06-11 | 1999-06-11 | Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200103581T2 true TR200103581T2 (tr) | 2002-08-21 |
Family
ID=11383150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/03581T TR200103581T2 (tr) | 1999-06-11 | 2000-06-07 | Graft versus host hastalığı tedavisinde CD20' ye karşı antikorların kullanımı. |
Country Status (26)
Country | Link |
---|---|
US (1) | US20070014785A1 (tr) |
EP (1) | EP1185299B1 (tr) |
JP (1) | JP2003501482A (tr) |
KR (1) | KR20020026455A (tr) |
CN (1) | CN1253208C (tr) |
AU (1) | AU774206B2 (tr) |
BG (1) | BG106193A (tr) |
CA (1) | CA2376288A1 (tr) |
CZ (1) | CZ20014450A3 (tr) |
DE (1) | DE60033030T2 (tr) |
DK (1) | DK1185299T3 (tr) |
EE (1) | EE200100667A (tr) |
ES (1) | ES2278616T3 (tr) |
HK (1) | HK1043549B (tr) |
HU (1) | HUP0201600A3 (tr) |
IL (1) | IL146934A0 (tr) |
IS (1) | IS6195A (tr) |
IT (1) | ITMI991299A1 (tr) |
NO (1) | NO20016035L (tr) |
NZ (1) | NZ515992A (tr) |
PL (1) | PL352860A1 (tr) |
PT (1) | PT1185299E (tr) |
SK (1) | SK18132001A3 (tr) |
TR (1) | TR200103581T2 (tr) |
WO (1) | WO2000076542A1 (tr) |
ZA (1) | ZA200110004B (tr) |
Families Citing this family (45)
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---|---|---|---|---|
AU777970C (en) | 1999-05-07 | 2006-08-17 | F. Hoffman-La Roche Ag | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
EP3263596A1 (en) * | 2002-12-16 | 2018-01-03 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
CN1316019C (zh) * | 2002-12-26 | 2007-05-16 | 中国医学科学院中国协和医科大学血液学研究所血液病医院 | 抗cd20嵌合抗体突变体基因及其应用 |
CA2519870A1 (en) | 2003-04-09 | 2004-10-28 | Genentech, Inc. | Use of rituximab intravenous compositions to treat rheumatoid arthritis |
JP5416338B2 (ja) | 2003-05-09 | 2014-02-12 | デューク ユニバーシティ | Cd20特異的抗体およびその使用方法 |
CA2526402A1 (en) | 2003-06-05 | 2005-01-20 | Genentech, Inc. | Blys antagonists and uses thereof |
US8530187B2 (en) * | 2004-03-22 | 2013-09-10 | The Ohio State University Research Foundation | Methods for transfecting natural killer cells |
CN106075435A (zh) | 2004-06-04 | 2016-11-09 | 健泰科生物技术公司 | 用于治疗多发性硬化的方法 |
BR122018016031B8 (pt) | 2004-08-04 | 2021-07-27 | Applied Molecular Evolution Inc | processo para produzir um anticorpo monoclonal variante com resposta de adcc realçada |
ATE460672T1 (de) | 2005-05-20 | 2010-03-15 | Genentech Inc | Vorbehandlung einer biologischen probe aus einem individuum mit autoimmunkrankheit |
WO2007014278A2 (en) | 2005-07-25 | 2007-02-01 | Trubion Pharmaceuticals, Inc. | B-cell reduction using cd37-specific and cd20-specific binding molecules |
CN101267836A (zh) | 2005-07-25 | 2008-09-17 | 特鲁比昂药品公司 | 单剂量cd20特异性结合分子的用途 |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
US9726673B2 (en) | 2005-11-23 | 2017-08-08 | Genentech, Inc. | Methods and compositions related to B cell assays |
CN101008291B (zh) * | 2006-01-26 | 2010-05-12 | 金海产品有限公司 | 用于水池清洁机的密封盒装置 |
WO2007146968A2 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
CA2584494A1 (en) * | 2007-03-27 | 2008-09-27 | Jeffrey A. Medin | Vector encoding therapeutic polypeptide and safety elements to clear transduced cells |
KR101432191B1 (ko) | 2007-06-22 | 2014-08-20 | 훗카이도 코리츠 다이가쿠 호진 삿포르 이카 다이가쿠 | 이식편대숙주 질환의 검출 또는 치료 방법 |
SG10202005450PA (en) | 2007-07-09 | 2020-07-29 | Genentech Inc | Prevention of disulfide bond reduction during recombinant production of polypeptides |
ES2527297T3 (es) | 2007-07-31 | 2015-01-22 | Regeneron Pharmaceuticals, Inc. | Anticuerpos humanos para CD20 humano y método para utilizar los mismos |
WO2009052293A1 (en) | 2007-10-16 | 2009-04-23 | Zymogenetics, Inc. | Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease |
EP2077281A1 (en) | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
WO2009114942A1 (en) | 2008-03-20 | 2009-09-24 | University Health Network | Thymidylate kinase fusions and uses thereof |
CN102099377A (zh) | 2008-04-11 | 2011-06-15 | 新兴产品开发西雅图有限公司 | Cd37免疫治疗剂及其与双功能化学治疗剂的联合 |
TW201014605A (en) * | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
RU2639288C2 (ru) | 2009-08-11 | 2017-12-20 | Дженентек, Инк. | Получение белков в культуральных средах без глутамина |
TW201129384A (en) | 2010-02-10 | 2011-09-01 | Immunogen Inc | CD20 antibodies and uses thereof |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
EP3221359B1 (en) | 2014-11-17 | 2020-05-27 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
BR112017024610A2 (pt) | 2015-06-24 | 2018-07-31 | F. Hoffmann-La Roche Ag | anticorpos para receptor antitransferrina com afinidade especificada |
CN108367004B (zh) | 2015-09-21 | 2022-09-13 | 阿帕特夫研究和发展有限公司 | Cd3结合多肽 |
CN114031689A (zh) | 2015-10-02 | 2022-02-11 | 豪夫迈·罗氏有限公司 | 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法 |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
CA3044526A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018183929A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
US20230009902A1 (en) | 2018-06-20 | 2023-01-12 | Progenity, Inc. | Treatment of a disease or condition in a tissue orginating from the endoderm |
US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
US11590223B2 (en) | 2018-08-31 | 2023-02-28 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for therapeutic antibodies |
EP3883636A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
EP4309722A2 (en) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272082A (en) * | 1992-03-30 | 1993-12-21 | The Wistar Institute Of Anatomy & Biology | Cytotoxic T-ALL cell lines and uses therefor |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
JP2000511539A (ja) * | 1996-05-31 | 2000-09-05 | ジェネティック・セラピー・インコーポレイテッド | 負の選択マーカーをコード化するポリヌクレオチドを含むt細胞による対宿主性移植片病の予防 |
GB9705744D0 (en) * | 1997-03-20 | 1997-05-07 | Davies Alison M | Methods for selecting cells and their uses |
-
1999
- 1999-06-11 IT IT1999MI001299A patent/ITMI991299A1/it unknown
-
2000
- 2000-06-07 PL PL00352860A patent/PL352860A1/xx not_active IP Right Cessation
- 2000-06-07 TR TR2001/03581T patent/TR200103581T2/tr unknown
- 2000-06-07 PT PT00940332T patent/PT1185299E/pt unknown
- 2000-06-07 CA CA002376288A patent/CA2376288A1/en not_active Abandoned
- 2000-06-07 DK DK00940332T patent/DK1185299T3/da active
- 2000-06-07 KR KR1020017015954A patent/KR20020026455A/ko active IP Right Grant
- 2000-06-07 IL IL14693400A patent/IL146934A0/xx unknown
- 2000-06-07 EP EP00940332A patent/EP1185299B1/en not_active Expired - Lifetime
- 2000-06-07 ES ES00940332T patent/ES2278616T3/es not_active Expired - Lifetime
- 2000-06-07 AU AU55303/00A patent/AU774206B2/en not_active Ceased
- 2000-06-07 NZ NZ515992A patent/NZ515992A/xx unknown
- 2000-06-07 CN CNB008088330A patent/CN1253208C/zh not_active Expired - Fee Related
- 2000-06-07 EE EEP200100667A patent/EE200100667A/xx unknown
- 2000-06-07 CZ CZ20014450A patent/CZ20014450A3/cs unknown
- 2000-06-07 HU HU0201600A patent/HUP0201600A3/hu unknown
- 2000-06-07 WO PCT/EP2000/005212 patent/WO2000076542A1/en active IP Right Grant
- 2000-06-07 DE DE60033030T patent/DE60033030T2/de not_active Expired - Fee Related
- 2000-06-07 SK SK1813-2001A patent/SK18132001A3/sk unknown
- 2000-06-07 JP JP2001502875A patent/JP2003501482A/ja active Pending
-
2001
- 2001-12-05 ZA ZA200110004A patent/ZA200110004B/xx unknown
- 2001-12-07 BG BG106193A patent/BG106193A/bg unknown
- 2001-12-10 NO NO20016035A patent/NO20016035L/no not_active Application Discontinuation
- 2001-12-10 IS IS6195A patent/IS6195A/is unknown
-
2002
- 2002-07-22 HK HK02105388.7A patent/HK1043549B/zh not_active IP Right Cessation
-
2006
- 2006-08-03 US US11/498,103 patent/US20070014785A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1185299A1 (en) | 2002-03-13 |
CN1253208C (zh) | 2006-04-26 |
SK18132001A3 (sk) | 2002-05-09 |
IS6195A (is) | 2001-12-10 |
HUP0201600A2 (en) | 2002-08-28 |
WO2000076542A1 (en) | 2000-12-21 |
ZA200110004B (en) | 2003-02-26 |
AU5530300A (en) | 2001-01-02 |
NZ515992A (en) | 2004-01-30 |
EP1185299B1 (en) | 2007-01-17 |
NO20016035D0 (no) | 2001-12-10 |
ITMI991299A1 (it) | 2000-12-11 |
IL146934A0 (en) | 2002-08-14 |
BG106193A (bg) | 2002-08-30 |
US20070014785A1 (en) | 2007-01-18 |
CZ20014450A3 (cs) | 2002-04-17 |
CN1355712A (zh) | 2002-06-26 |
AU774206B2 (en) | 2004-06-17 |
PL352860A1 (en) | 2003-09-08 |
HUP0201600A3 (en) | 2005-04-28 |
DK1185299T3 (da) | 2007-05-21 |
EE200100667A (et) | 2003-02-17 |
ITMI991299A0 (it) | 1999-06-11 |
JP2003501482A (ja) | 2003-01-14 |
ES2278616T3 (es) | 2007-08-16 |
DE60033030D1 (de) | 2007-03-08 |
NO20016035L (no) | 2002-02-11 |
PT1185299E (pt) | 2007-03-30 |
KR20020026455A (ko) | 2002-04-10 |
HK1043549A1 (en) | 2002-09-20 |
HK1043549B (zh) | 2006-09-01 |
DE60033030T2 (de) | 2007-05-31 |
CA2376288A1 (en) | 2000-12-21 |
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