HK1043549B - 利用抗cd20抗體治療移植物抗宿主疾病 - Google Patents
利用抗cd20抗體治療移植物抗宿主疾病Info
- Publication number
- HK1043549B HK1043549B HK02105388.7A HK02105388A HK1043549B HK 1043549 B HK1043549 B HK 1043549B HK 02105388 A HK02105388 A HK 02105388A HK 1043549 B HK1043549 B HK 1043549B
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- antibodies against
- host disease
- versus host
- graft versus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001299A ITMI991299A1 (it) | 1999-06-11 | 1999-06-11 | Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite |
PCT/EP2000/005212 WO2000076542A1 (en) | 1999-06-11 | 2000-06-07 | Use of antibodies against cd20 for the treatment of the graft versus host disease |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1043549A1 HK1043549A1 (en) | 2002-09-20 |
HK1043549B true HK1043549B (zh) | 2006-09-01 |
Family
ID=11383150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02105388.7A HK1043549B (zh) | 1999-06-11 | 2002-07-22 | 利用抗cd20抗體治療移植物抗宿主疾病 |
Country Status (26)
Country | Link |
---|---|
US (1) | US20070014785A1 (zh) |
EP (1) | EP1185299B1 (zh) |
JP (1) | JP2003501482A (zh) |
KR (1) | KR20020026455A (zh) |
CN (1) | CN1253208C (zh) |
AU (1) | AU774206B2 (zh) |
BG (1) | BG106193A (zh) |
CA (1) | CA2376288A1 (zh) |
CZ (1) | CZ20014450A3 (zh) |
DE (1) | DE60033030T2 (zh) |
DK (1) | DK1185299T3 (zh) |
EE (1) | EE200100667A (zh) |
ES (1) | ES2278616T3 (zh) |
HK (1) | HK1043549B (zh) |
HU (1) | HUP0201600A3 (zh) |
IL (1) | IL146934A0 (zh) |
IS (1) | IS6195A (zh) |
IT (1) | ITMI991299A1 (zh) |
NO (1) | NO20016035L (zh) |
NZ (1) | NZ515992A (zh) |
PL (1) | PL352860A1 (zh) |
PT (1) | PT1185299E (zh) |
SK (1) | SK18132001A3 (zh) |
TR (1) | TR200103581T2 (zh) |
WO (1) | WO2000076542A1 (zh) |
ZA (1) | ZA200110004B (zh) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
EP1944320A1 (en) * | 2002-12-16 | 2008-07-16 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
CN1316019C (zh) * | 2002-12-26 | 2007-05-16 | 中国医学科学院中国协和医科大学血液学研究所血液病医院 | 抗cd20嵌合抗体突变体基因及其应用 |
MXPA05010778A (es) | 2003-04-09 | 2005-12-12 | Genentech Inc | Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa. |
WO2005000901A2 (en) | 2003-05-09 | 2005-01-06 | Duke University | Cd20-specific antibodies and methods of employing same |
MXPA05013117A (es) | 2003-06-05 | 2006-03-17 | Genentech Inc | Terapia de combinacion para trastornos de celulas-b. |
WO2005093079A1 (en) * | 2004-03-22 | 2005-10-06 | The Ohio State University Research Foundation | Methods for transfecting natural killer cells |
AR049200A1 (es) | 2004-06-04 | 2006-07-05 | Genentech Inc | Metodo para tratar esclerosis multiple con una composicion que contiene un anticuerpo cd20 |
WO2006020114A2 (en) | 2004-08-04 | 2006-02-23 | Applied Molecular Evolution, Inc. | Variant fc regions |
EP1902320B1 (en) | 2005-05-20 | 2010-03-10 | Genentech, Inc. | Pretreatment of a biological sample from an autoimmune disease subject |
RS54088B1 (en) | 2005-07-25 | 2015-10-30 | Emergent Products Development Seattle Llc | B-CELL REDUCTION BY USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES |
CA2616386A1 (en) | 2005-07-25 | 2007-02-01 | Trubion Pharmaceuticals Inc. | Single dose use of cd20-specific binding molecules |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
AU2006318539B2 (en) | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
CN101008291B (zh) * | 2006-01-26 | 2010-05-12 | 金海产品有限公司 | 用于水池清洁机的密封盒装置 |
KR101571027B1 (ko) | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
CA2584494A1 (en) * | 2007-03-27 | 2008-09-27 | Jeffrey A. Medin | Vector encoding therapeutic polypeptide and safety elements to clear transduced cells |
EP2163896B1 (en) * | 2007-06-22 | 2013-09-25 | Sapporo Medical University | Method for detection or treatment of graft versus host disease |
KR101643514B1 (ko) | 2007-07-09 | 2016-07-27 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
CN101809037B (zh) | 2007-07-31 | 2014-01-15 | 瑞泽恩制药公司 | 人cd20的人抗体及其使用方法 |
EP2233149B1 (en) | 2007-10-16 | 2016-02-10 | ZymoGenetics, Inc. | Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for treatment of autoimmune disease |
EP2077281A1 (en) | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
US8568709B2 (en) | 2008-03-20 | 2013-10-29 | University Health Network | Thymidylate kinase fusions and uses thereof |
NZ588671A (en) | 2008-04-11 | 2012-11-30 | Emergent Product Dev Seattle | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
AR073295A1 (es) | 2008-09-16 | 2010-10-28 | Genentech Inc | Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
KR20180010324A (ko) | 2009-08-11 | 2018-01-30 | 제넨테크, 인크. | 글루타민-비함유 세포 배양 배지에서의 단백질의 생성 |
MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
HUE050831T2 (hu) | 2014-11-17 | 2021-01-28 | Regeneron Pharma | Daganatkezelési módszerek a CD3XCD20 bispecifikus antitest használatával |
RS60441B1 (sr) | 2015-05-30 | 2020-07-31 | Molecular Templates Inc | De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti |
PE20221007A1 (es) | 2015-06-24 | 2022-06-15 | Hoffmann La Roche | Anticuerpos anti-receptor de transferrina con afinidad disenada |
CA2999138C (en) | 2015-09-21 | 2024-05-21 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
CN114031689A (zh) | 2015-10-02 | 2022-02-11 | 豪夫迈·罗氏有限公司 | 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法 |
EP4252629A3 (en) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Gastrointestinal tract detection methods, devices and systems |
EP3600416B1 (en) | 2017-03-30 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
US20230009902A1 (en) | 2018-06-20 | 2023-01-12 | Progenity, Inc. | Treatment of a disease or condition in a tissue orginating from the endoderm |
AU2019331024A1 (en) | 2018-08-31 | 2021-03-18 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for CD3/C20 bispecific antibodies |
EP3883634A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
EP4309722A2 (en) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272082A (en) * | 1992-03-30 | 1993-12-21 | The Wistar Institute Of Anatomy & Biology | Cytotoxic T-ALL cell lines and uses therefor |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
NZ333053A (en) * | 1996-05-31 | 2000-06-23 | Genetic Therapy Inc | Use of an interaction agent or T-cells having polynucleotides encoding negative selective markers to prevent graft-versus-host disease |
GB9705744D0 (en) * | 1997-03-20 | 1997-05-07 | Davies Alison M | Methods for selecting cells and their uses |
-
1999
- 1999-06-11 IT IT1999MI001299A patent/ITMI991299A1/it unknown
-
2000
- 2000-06-07 ES ES00940332T patent/ES2278616T3/es not_active Expired - Lifetime
- 2000-06-07 CA CA002376288A patent/CA2376288A1/en not_active Abandoned
- 2000-06-07 NZ NZ515992A patent/NZ515992A/xx unknown
- 2000-06-07 TR TR2001/03581T patent/TR200103581T2/xx unknown
- 2000-06-07 DK DK00940332T patent/DK1185299T3/da active
- 2000-06-07 CZ CZ20014450A patent/CZ20014450A3/cs unknown
- 2000-06-07 SK SK1813-2001A patent/SK18132001A3/sk unknown
- 2000-06-07 DE DE60033030T patent/DE60033030T2/de not_active Expired - Fee Related
- 2000-06-07 HU HU0201600A patent/HUP0201600A3/hu unknown
- 2000-06-07 EE EEP200100667A patent/EE200100667A/xx unknown
- 2000-06-07 AU AU55303/00A patent/AU774206B2/en not_active Ceased
- 2000-06-07 EP EP00940332A patent/EP1185299B1/en not_active Expired - Lifetime
- 2000-06-07 PT PT00940332T patent/PT1185299E/pt unknown
- 2000-06-07 PL PL00352860A patent/PL352860A1/xx not_active IP Right Cessation
- 2000-06-07 IL IL14693400A patent/IL146934A0/xx unknown
- 2000-06-07 KR KR1020017015954A patent/KR20020026455A/ko active IP Right Grant
- 2000-06-07 WO PCT/EP2000/005212 patent/WO2000076542A1/en active IP Right Grant
- 2000-06-07 CN CNB008088330A patent/CN1253208C/zh not_active Expired - Fee Related
- 2000-06-07 JP JP2001502875A patent/JP2003501482A/ja active Pending
-
2001
- 2001-12-05 ZA ZA200110004A patent/ZA200110004B/xx unknown
- 2001-12-07 BG BG106193A patent/BG106193A/bg unknown
- 2001-12-10 IS IS6195A patent/IS6195A/is unknown
- 2001-12-10 NO NO20016035A patent/NO20016035L/no not_active Application Discontinuation
-
2002
- 2002-07-22 HK HK02105388.7A patent/HK1043549B/zh not_active IP Right Cessation
-
2006
- 2006-08-03 US US11/498,103 patent/US20070014785A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070014785A1 (en) | 2007-01-18 |
EP1185299B1 (en) | 2007-01-17 |
CA2376288A1 (en) | 2000-12-21 |
DE60033030D1 (de) | 2007-03-08 |
CN1355712A (zh) | 2002-06-26 |
TR200103581T2 (tr) | 2002-08-21 |
JP2003501482A (ja) | 2003-01-14 |
HUP0201600A3 (en) | 2005-04-28 |
KR20020026455A (ko) | 2002-04-10 |
ES2278616T3 (es) | 2007-08-16 |
ITMI991299A0 (it) | 1999-06-11 |
NZ515992A (en) | 2004-01-30 |
EP1185299A1 (en) | 2002-03-13 |
PL352860A1 (en) | 2003-09-08 |
DK1185299T3 (da) | 2007-05-21 |
IS6195A (is) | 2001-12-10 |
ZA200110004B (en) | 2003-02-26 |
HK1043549A1 (en) | 2002-09-20 |
IL146934A0 (en) | 2002-08-14 |
BG106193A (bg) | 2002-08-30 |
CN1253208C (zh) | 2006-04-26 |
ITMI991299A1 (it) | 2000-12-11 |
WO2000076542A1 (en) | 2000-12-21 |
DE60033030T2 (de) | 2007-05-31 |
EE200100667A (et) | 2003-02-17 |
NO20016035D0 (no) | 2001-12-10 |
HUP0201600A2 (en) | 2002-08-28 |
AU774206B2 (en) | 2004-06-17 |
NO20016035L (no) | 2002-02-11 |
CZ20014450A3 (cs) | 2002-04-17 |
SK18132001A3 (sk) | 2002-05-09 |
AU5530300A (en) | 2001-01-02 |
PT1185299E (pt) | 2007-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20100607 |