TR200002838T2 - Bir sefalosporin türevinin arıtımı için proses - Google Patents

Bir sefalosporin türevinin arıtımı için proses

Info

Publication number
TR200002838T2
TR200002838T2 TR2000/02838T TR200002838T TR200002838T2 TR 200002838 T2 TR200002838 T2 TR 200002838T2 TR 2000/02838 T TR2000/02838 T TR 2000/02838T TR 200002838 T TR200002838 T TR 200002838T TR 200002838 T2 TR200002838 T2 TR 200002838T2
Authority
TR
Turkey
Prior art keywords
purification
cephalosporin derivative
cefixime
ceph
vwhich
Prior art date
Application number
TR2000/02838T
Other languages
English (en)
Inventor
Decristoforo Martin
Ludescher Johannes
Sturm Hubert
Veit Werner
Original Assignee
Biochemie Gesellschaft M.B.H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gesellschaft M.B.H filed Critical Biochemie Gesellschaft M.B.H
Publication of TR200002838T2 publication Critical patent/TR200002838T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Kristal halinde olabilen ve 7-amino-3-vinil-sef-3-em-4-karboksilik asitten, bir-kaplik bir reaksiyonda üretilebilen bir sefiksim ara maddesinin yeni bir tert. oktilamin tuzu vasitasiyla, sefiksimin aritilmasi için bir proses.
TR2000/02838T 1998-04-02 1999-03-31 Bir sefalosporin türevinin arıtımı için proses TR200002838T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0057598A AT406773B (de) 1998-04-02 1998-04-02 Neues salz von 7-(2-(aminothiazol-4yl)-2-

Publications (1)

Publication Number Publication Date
TR200002838T2 true TR200002838T2 (tr) 2001-02-21

Family

ID=3494225

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02838T TR200002838T2 (tr) 1998-04-02 1999-03-31 Bir sefalosporin türevinin arıtımı için proses

Country Status (16)

Country Link
US (1) US6825345B2 (tr)
EP (1) EP1068211B1 (tr)
JP (1) JP2002510694A (tr)
KR (1) KR20010034671A (tr)
CN (1) CN1134447C (tr)
AT (2) AT406773B (tr)
AU (1) AU3603599A (tr)
BR (1) BR9909898A (tr)
CA (1) CA2326441C (tr)
DE (1) DE69937143T2 (tr)
ES (1) ES2293720T3 (tr)
HK (1) HK1034078A1 (tr)
ID (1) ID26210A (tr)
TR (1) TR200002838T2 (tr)
WO (1) WO1999051607A2 (tr)
ZA (1) ZA200004899B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404727B (de) * 1997-01-16 1999-02-25 Biochemie Gmbh Kristallines salz von cefixim und verfahren zu dessen herstellung
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
AU2003276525A1 (en) * 2002-11-15 2004-06-15 Orchid Chemicals And Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
US7662955B2 (en) * 2003-03-20 2010-02-16 Orchid Chemicals And Pharmaceuticals Ltd. Process for the preparation of cefoxitin
US8008478B2 (en) 2004-12-21 2011-08-30 Lupin Limited Process for the preparation of cefixime
WO2006103686A1 (en) * 2005-03-29 2006-10-05 Hetero Drugs Limited An improved process for the preparation of cefixime
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
CN101812075B (zh) * 2010-05-07 2012-06-13 郝志艳 一种头孢克肟化合物及其新制法
CN103265562A (zh) * 2013-05-29 2013-08-28 四川方向药业有限责任公司 头孢克肟的制备方法
CN103965217A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 3-三嗪环-7-（噻唑羧甲氧亚氨基）头孢烷酸的制备方法
CN103965216A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 7-（噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法
WO2016142902A1 (en) * 2015-03-11 2016-09-15 Lupin Limited Cefixime with reduced surface area and high stability

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS58986A (ja) * 1981-05-07 1983-01-06 Fujisawa Pharmaceut Co Ltd セフェム化合物
JPS57192392A (en) * 1981-05-19 1982-11-26 Sankyo Co Ltd Production of 3-alkoxymethylcephalosporin
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
DE3377061D1 (en) * 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
DE3372768D1 (de) 1982-06-03 1987-09-03 Hoffmann La Roche 1-sulfo-2-oxoazetidine derivatives
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
JPH0692416B2 (ja) * 1985-03-13 1994-11-16 三共株式会社 セフアロスポラン酸誘導体
EP0231845B1 (de) * 1986-02-07 1992-06-17 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Carbonsäureamiden
US5359057A (en) 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
JPH01242589A (ja) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd セフエム化合物
WO1993016084A1 (en) * 1992-02-05 1993-08-19 Biochemie Gesellschaft M.B.H. Process for the purification of a 3-cephem-4-carboxylic acid derivative
DE69427312T2 (de) * 1993-11-17 2001-08-23 Biochemie Gmbh Trennung von Cephalosporinisomeren
AT403049B (de) * 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
EP0831093A1 (en) * 1996-09-23 1998-03-25 F. Hoffmann-La Roche Ag 1-Carba-(dethia)-Cephalosporin Derivatives
TW538045B (en) * 1997-01-16 2003-06-21 Biochemie Gmbh Process for purifying cefixime

Also Published As

Publication number Publication date
WO1999051607A2 (en) 1999-10-14
CA2326441C (en) 2008-03-18
AU3603599A (en) 1999-10-25
KR20010034671A (ko) 2001-04-25
JP2002510694A (ja) 2002-04-09
BR9909898A (pt) 2000-12-26
EP1068211B1 (en) 2007-09-19
CN1295576A (zh) 2001-05-16
ES2293720T3 (es) 2008-03-16
US6825345B2 (en) 2004-11-30
DE69937143D1 (de) 2007-10-31
HK1034078A1 (en) 2001-10-12
ATA57598A (de) 2000-01-15
EP1068211A2 (en) 2001-01-17
US20030208065A1 (en) 2003-11-06
ZA200004899B (en) 2001-12-24
ATE373666T1 (de) 2007-10-15
AT406773B (de) 2000-08-25
CN1134447C (zh) 2004-01-14
ID26210A (id) 2000-12-07
WO1999051607A3 (en) 2000-01-27
CA2326441A1 (en) 1999-10-14
DE69937143T2 (de) 2008-06-12

Similar Documents

Publication Publication Date Title
NL350075I2 (tr)
NZ278072A (en) Phenylacetic acid oxime derivatives; biocides
BR9900177A (pt) Inibidores de metaloprotease.
TR200002838T2 (tr) Bir sefalosporin türevinin arıtımı için proses
GB9722520D0 (en) Compounds
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
EA200000826A1 (ru) Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
TR200403436T2 (tr) Kristalin 1-metilkarbapenem türevleri.
SE8107273L (sv) 2-oxoazetidinderivat, sett att framstella democh anvendning derav
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
ES8606360A1 (es) Un derivado de cefalosporina.
ID28144A (id) Proses pemurnian asam isoftalat melalui kristalisasi
BR0013751A (pt) Processo para produção de derivados de ácido naftiridina-3-carboxìlico
AP2000001760A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
DE60000978T2 (de) 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose
PT1165444E (pt) Utilizacao de derivados de porfirina em aquarios
BG106117A (en) Novel 8a- and 9a-15-membered lactams
IS8034A (is) Imídasó[4,5-B]kínólínafleiður og notkun þeirra sem NO-myndunarhemla
TR199902117T2 (tr) (E)-4,6- Dikloro-3-(2-okso-1-fenilpirolidin-3-iliden metil)-1H-Indol-2-karboksilik asidin kristalimsi hidratlanmis sodyum tuzu.
PL345966A1 (en) N-substituted azabicycloheptane derivatives, production and use thereof
MXPA04002640A (es) Esteres de analogos de 3-desoxi-vitamina d3.
BG105780A (en) Method for producing derivatives of biphenyl-2-carboxylic acid
MXPA05011840A (es) Procedimiento para cristalizar sales de guanidinio.
RS20050620A (en) Nitrate esters of phenylaminothiophenacetic acid derivatives
BG105329A (en) N-substituted azabicycloheptane derivatives, production and use thereof