BR9909898A - Processo para purificação de um derivado de cefalosporina - Google Patents
Processo para purificação de um derivado de cefalosporinaInfo
- Publication number
- BR9909898A BR9909898A BR9909898-9A BR9909898A BR9909898A BR 9909898 A BR9909898 A BR 9909898A BR 9909898 A BR9909898 A BR 9909898A BR 9909898 A BR9909898 A BR 9909898A
- Authority
- BR
- Brazil
- Prior art keywords
- purification
- cephalosporin derivative
- cefixime
- ceph
- vwhich
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA PURIFICAçãO DE UM DERIVADO DE CEFALOSPORINA"<D>. Processo para purificação de cefixima através de um novo sal de terc-octilamina de um intermediário que pode ser cristalino e que pode ser produzido em uma reação de pote de ácido 7-amino-3-vinil-cef-3-em-4-carboxílico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0057598A AT406773B (de) | 1998-04-02 | 1998-04-02 | Neues salz von 7-(2-(aminothiazol-4yl)-2- |
PCT/EP1999/002222 WO1999051607A2 (en) | 1998-04-02 | 1999-03-31 | Process for purification of a cephalosporin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909898A true BR9909898A (pt) | 2000-12-26 |
Family
ID=3494225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909898-9A BR9909898A (pt) | 1998-04-02 | 1999-03-31 | Processo para purificação de um derivado de cefalosporina |
Country Status (16)
Country | Link |
---|---|
US (1) | US6825345B2 (pt) |
EP (1) | EP1068211B1 (pt) |
JP (1) | JP2002510694A (pt) |
KR (1) | KR20010034671A (pt) |
CN (1) | CN1134447C (pt) |
AT (2) | AT406773B (pt) |
AU (1) | AU3603599A (pt) |
BR (1) | BR9909898A (pt) |
CA (1) | CA2326441C (pt) |
DE (1) | DE69937143T2 (pt) |
ES (1) | ES2293720T3 (pt) |
HK (1) | HK1034078A1 (pt) |
ID (1) | ID26210A (pt) |
TR (1) | TR200002838T2 (pt) |
WO (1) | WO1999051607A2 (pt) |
ZA (1) | ZA200004899B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT404727B (de) * | 1997-01-16 | 1999-02-25 | Biochemie Gmbh | Kristallines salz von cefixim und verfahren zu dessen herstellung |
ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
US7244842B2 (en) * | 2002-11-15 | 2007-07-17 | Orchid Chemicals & Pharmaceuticals Ltd. | Amorphous hydrate of a cephalosporin antibiotic |
US7662955B2 (en) * | 2003-03-20 | 2010-02-16 | Orchid Chemicals And Pharmaceuticals Ltd. | Process for the preparation of cefoxitin |
MX2007007476A (es) * | 2004-12-21 | 2007-08-15 | Lupin Ltd | Proceso para la preparacion de cefixima. |
US7705142B2 (en) * | 2005-03-29 | 2010-04-27 | Hetero Drugs Limited | Process for the preparation of cefixime |
CN1312158C (zh) * | 2005-05-20 | 2007-04-25 | 天津市医药集团技术发展有限公司 | 一种头孢克肟的制备方法 |
CN101812075B (zh) * | 2010-05-07 | 2012-06-13 | 郝志艳 | 一种头孢克肟化合物及其新制法 |
CN103265562A (zh) * | 2013-05-29 | 2013-08-28 | 四川方向药业有限责任公司 | 头孢克肟的制备方法 |
CN103965216A (zh) * | 2014-05-21 | 2014-08-06 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 7-(噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法 |
CN103965217A (zh) * | 2014-05-21 | 2014-08-06 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 3-三嗪环-7-(噻唑羧甲氧亚氨基)头孢烷酸的制备方法 |
WO2016142902A1 (en) * | 2015-03-11 | 2016-09-15 | Lupin Limited | Cefixime with reduced surface area and high stability |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
JPS58986A (ja) * | 1981-05-07 | 1983-01-06 | Fujisawa Pharmaceut Co Ltd | セフェム化合物 |
JPS57192392A (en) * | 1981-05-19 | 1982-11-26 | Sankyo Co Ltd | Production of 3-alkoxymethylcephalosporin |
AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
EP0096297B1 (de) * | 1982-06-03 | 1988-06-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten |
EP0096296B1 (de) | 1982-06-03 | 1987-07-29 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1-Sulfo-2-oxoazetidinderivate |
JPS59163387A (ja) * | 1983-03-07 | 1984-09-14 | Sankyo Co Ltd | 3−アルコキシメチルセフアロスポリンの製造方法 |
JPH0692416B2 (ja) * | 1985-03-13 | 1994-11-16 | 三共株式会社 | セフアロスポラン酸誘導体 |
DE3779768D1 (de) * | 1986-02-07 | 1992-07-23 | Hoffmann La Roche | Verfahren zur herstellung von carbonsaeureamiden. |
US5359057A (en) | 1986-02-07 | 1994-10-25 | Hoffmann-La Roche Inc. | Acylation of amines |
JPH01242589A (ja) * | 1988-03-22 | 1989-09-27 | Fujisawa Pharmaceut Co Ltd | セフエム化合物 |
KR950700311A (ko) * | 1992-02-05 | 1995-01-16 | 게오르게스 그렐리니, 한스 루돌프하우스 | 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives) |
DK0658558T3 (da) * | 1993-11-17 | 2001-04-17 | Biochemie Gmbh | Adskillelse af cephalosporinisomere |
AT403049B (de) * | 1995-08-14 | 1997-10-27 | Biochemie Gmbh | Abreicherung von 7-adca in 3-vinyl-aca |
AT404251B (de) * | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
EP0831093A1 (en) * | 1996-09-23 | 1998-03-25 | F. Hoffmann-La Roche Ag | 1-Carba-(dethia)-Cephalosporin Derivatives |
TW538045B (en) * | 1997-01-16 | 2003-06-21 | Biochemie Gmbh | Process for purifying cefixime |
-
1998
- 1998-04-02 AT AT0057598A patent/AT406773B/de not_active IP Right Cessation
-
1999
- 1999-03-31 CN CNB998046205A patent/CN1134447C/zh not_active Expired - Fee Related
- 1999-03-31 ES ES99917938T patent/ES2293720T3/es not_active Expired - Lifetime
- 1999-03-31 AT AT99917938T patent/ATE373666T1/de not_active IP Right Cessation
- 1999-03-31 DE DE69937143T patent/DE69937143T2/de not_active Expired - Lifetime
- 1999-03-31 ID IDW20001932A patent/ID26210A/id unknown
- 1999-03-31 BR BR9909898-9A patent/BR9909898A/pt not_active Application Discontinuation
- 1999-03-31 KR KR1020007010634A patent/KR20010034671A/ko not_active Application Discontinuation
- 1999-03-31 JP JP2000542328A patent/JP2002510694A/ja active Pending
- 1999-03-31 WO PCT/EP1999/002222 patent/WO1999051607A2/en active IP Right Grant
- 1999-03-31 CA CA002326441A patent/CA2326441C/en not_active Expired - Fee Related
- 1999-03-31 EP EP99917938A patent/EP1068211B1/en not_active Expired - Lifetime
- 1999-03-31 TR TR2000/02838T patent/TR200002838T2/xx unknown
- 1999-03-31 AU AU36035/99A patent/AU3603599A/en not_active Abandoned
-
2000
- 2000-09-14 ZA ZA200004899A patent/ZA200004899B/xx unknown
-
2001
- 2001-07-03 HK HK01104565A patent/HK1034078A1/xx not_active IP Right Cessation
-
2002
- 2002-09-30 US US10/261,748 patent/US6825345B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999051607A3 (en) | 2000-01-27 |
CN1134447C (zh) | 2004-01-14 |
EP1068211A2 (en) | 2001-01-17 |
DE69937143T2 (de) | 2008-06-12 |
CA2326441A1 (en) | 1999-10-14 |
ES2293720T3 (es) | 2008-03-16 |
ZA200004899B (en) | 2001-12-24 |
ATE373666T1 (de) | 2007-10-15 |
CA2326441C (en) | 2008-03-18 |
AU3603599A (en) | 1999-10-25 |
DE69937143D1 (de) | 2007-10-31 |
US20030208065A1 (en) | 2003-11-06 |
US6825345B2 (en) | 2004-11-30 |
CN1295576A (zh) | 2001-05-16 |
EP1068211B1 (en) | 2007-09-19 |
AT406773B (de) | 2000-08-25 |
ATA57598A (de) | 2000-01-15 |
TR200002838T2 (tr) | 2001-02-21 |
ID26210A (id) | 2000-12-07 |
HK1034078A1 (en) | 2001-10-12 |
KR20010034671A (ko) | 2001-04-25 |
WO1999051607A2 (en) | 1999-10-14 |
JP2002510694A (ja) | 2002-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT. CL: CO7D 501/22; CO7D 277/82; CO7D 501/00; CO7D 501/06; CO7D 277/74; A61K 31/546. Ipc: C07D 501/22 (2008.04), C07D 277/74 (2008.04) |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O, 13 E 25 DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |