TR200001580T2 - Spesifik etkinliği yüksek eritropoyetin - Google Patents
Spesifik etkinliği yüksek eritropoyetinInfo
- Publication number
- TR200001580T2 TR200001580T2 TR2000/01580T TR200001580T TR200001580T2 TR 200001580 T2 TR200001580 T2 TR 200001580T2 TR 2000/01580 T TR2000/01580 T TR 2000/01580T TR 200001580 T TR200001580 T TR 200001580T TR 200001580 T2 TR200001580 T2 TR 200001580T2
- Authority
- TR
- Turkey
- Prior art keywords
- specific activity
- high specific
- erythropoietin
- compounds
- relates
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title 1
- 108090000394 Erythropoietin Proteins 0.000 title 1
- 229940105423 erythropoietin Drugs 0.000 title 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
- KFEUJDWYNGMDBV-LODBTCKLSA-N N-acetyllactosamine Chemical group O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KFEUJDWYNGMDBV-LODBTCKLSA-N 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bu bulus spesifik etkinligi yüksek yeni EPO bilesimlerine iliskindir. bu bilesimlerin özelligi karbonhidrat yapisinda yüksek N-asetil-laktosamin birim muhteviyati ve/veya dört antenli dallardir. Bulus böyle EPO ürünleri üretmek için bir isleme de iliskindir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997153681 DE19753681A1 (de) | 1997-12-03 | 1997-12-03 | Erythropoietin mit hoher spezifischer Aktivität |
EP98113415 | 1998-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001580T2 true TR200001580T2 (tr) | 2000-12-21 |
Family
ID=26042142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01580T TR200001580T2 (tr) | 1997-12-03 | 1998-12-03 | Spesifik etkinliği yüksek eritropoyetin |
Country Status (12)
Country | Link |
---|---|
US (1) | US7659373B2 (tr) |
EP (1) | EP1037921B1 (tr) |
JP (3) | JP4220125B2 (tr) |
KR (1) | KR100390325B1 (tr) |
CN (1) | CN1280309C (tr) |
AR (1) | AR022358A1 (tr) |
AU (1) | AU744086B2 (tr) |
BR (1) | BR9813391C1 (tr) |
CA (1) | CA2309810C (tr) |
ES (1) | ES2523599T3 (tr) |
TR (1) | TR200001580T2 (tr) |
WO (1) | WO1999028346A1 (tr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
WO2003060071A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
SI1492878T1 (sl) * | 2002-03-26 | 2007-12-31 | Lek Pharmaceutical And Chemical Co. D.D. | Postopek za pripravo Ĺľelenega profila gliko-izoform eritropoietina |
DK1543106T3 (da) | 2002-07-15 | 2007-08-13 | Immunex Corp | Fremgangsmåder og medier til kontrol af sialylering af proteiner, der dannes af mammaliaceller |
KR100473658B1 (ko) * | 2002-10-25 | 2005-03-10 | 드림바이오젠 주식회사 | 위치 선택적 수식법에 의한 혼성형 단백질 치료제 개발을 위한 형질전환 효모 시스템 |
KR100473659B1 (ko) * | 2002-10-25 | 2005-03-15 | 드림바이오젠 주식회사 | 당사슬 위치에 위치선택적 수식법으로 유용한 고분자를수식시킨 혼성형 단백질의 제조방법 |
EP1623023B1 (en) | 2003-05-09 | 2008-11-12 | Crucell Holland B.V. | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom |
DE102004027816A1 (de) | 2004-06-08 | 2006-01-05 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von Erythropoietin |
WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
US8255487B2 (en) * | 2008-05-16 | 2012-08-28 | Integrated Illumination Systems, Inc. | Systems and methods for communicating in a lighting network |
ES2435272T3 (es) * | 2008-09-23 | 2013-12-17 | F. Hoffmann-La Roche Ag | Purificación de la eritropoyetina |
CA2775012A1 (en) * | 2009-09-23 | 2011-03-31 | Biogenerix Ag | Process for the purification of recombinant human erythropoietin (epo), epo thus purified and pharmaceutical compositions comprising same |
US8951807B2 (en) | 2010-01-15 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
US8895707B2 (en) * | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
WO2012050175A1 (ja) | 2010-10-15 | 2012-04-19 | 日本ケミカルリサーチ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
CA2825651C (en) | 2011-02-02 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
KR101443257B1 (ko) | 2011-10-18 | 2014-09-19 | 주식회사 종근당 | 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법 |
CN104507952B (zh) | 2012-05-30 | 2018-08-10 | 生物辐射实验室股份有限公司 | 基于磷灰石的色谱树脂的原位恢复 |
JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
CN105517718B (zh) | 2014-06-23 | 2019-12-31 | 生物辐射实验室股份有限公司 | 磷灰石原位恢复 |
EP3157689B1 (en) | 2014-06-23 | 2021-04-28 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
JP2020511499A (ja) | 2017-03-20 | 2020-04-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 赤血球生成刺激タンパク質のインビトロでの糖鎖改変のための方法 |
EP4219537A1 (en) * | 2020-09-22 | 2023-08-02 | Jecho Laboratories, Inc. | Glycosylation-modified erythopoietin and use thereof |
WO2024094457A1 (en) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Method for producing glycoprotein compositions |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4745099A (en) * | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
US4954437A (en) * | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
DE3924746A1 (de) * | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
DE4028800A1 (de) * | 1990-09-11 | 1992-03-12 | Behringwerke Ag | Gentechnische sialylierung von glykoproteinen |
US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
US5459031A (en) * | 1993-11-05 | 1995-10-17 | Amgen Inc. | Methods for controlling sialic acid derivatives in recombinant glycoproteins |
FR2716682B1 (fr) * | 1994-01-28 | 1996-04-26 | Centre Nat Rech Scient | Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations. |
TW448184B (en) * | 1994-11-01 | 2001-08-01 | Kirin Brewery | Peptide sequence that forms muscous glycoprotein chain and technique for producing thereof |
IL118201A (en) | 1995-05-11 | 2004-12-15 | Roche Diagnostics Gmbh | Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof |
JP4541539B2 (ja) | 1997-07-23 | 2010-09-08 | ロシュ ダイアグノスティックス ゲーエムベーハー | 内因性遺伝子活性化によるエリスロポエチンの製造 |
-
1998
- 1998-12-03 KR KR10-2000-7006085A patent/KR100390325B1/ko not_active IP Right Cessation
- 1998-12-03 AU AU21581/99A patent/AU744086B2/en not_active Expired
- 1998-12-03 WO PCT/EP1998/007876 patent/WO1999028346A1/de active IP Right Grant
- 1998-12-03 CA CA2309810A patent/CA2309810C/en not_active Expired - Lifetime
- 1998-12-03 BR BRPI9813391A patent/BR9813391C1/pt not_active IP Right Cessation
- 1998-12-03 AR ARP980106125A patent/AR022358A1/es not_active Application Discontinuation
- 1998-12-03 TR TR2000/01580T patent/TR200001580T2/tr unknown
- 1998-12-03 JP JP2000523237A patent/JP4220125B2/ja not_active Expired - Fee Related
- 1998-12-03 EP EP98965756.4A patent/EP1037921B1/de not_active Expired - Lifetime
- 1998-12-03 ES ES98965756.4T patent/ES2523599T3/es not_active Expired - Lifetime
- 1998-12-03 CN CNB988117924A patent/CN1280309C/zh not_active Expired - Lifetime
-
2003
- 2003-03-03 JP JP2003055499A patent/JP3673261B2/ja not_active Expired - Lifetime
-
2004
- 2004-07-27 JP JP2004219290A patent/JP4234647B2/ja not_active Expired - Lifetime
-
2005
- 2005-08-09 US US11/201,006 patent/US7659373B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU744086B2 (en) | 2002-02-14 |
CN1280586A (zh) | 2001-01-17 |
CA2309810C (en) | 2014-07-08 |
ES2523599T3 (es) | 2014-11-27 |
JP4220125B2 (ja) | 2009-02-04 |
KR20010024681A (ko) | 2001-03-26 |
WO1999028346A1 (de) | 1999-06-10 |
KR100390325B1 (ko) | 2003-07-07 |
JP2003238593A (ja) | 2003-08-27 |
AR022358A1 (es) | 2002-09-04 |
EP1037921B1 (de) | 2014-09-24 |
US20050288220A1 (en) | 2005-12-29 |
JP2001525338A (ja) | 2001-12-11 |
JP2004339234A (ja) | 2004-12-02 |
US7659373B2 (en) | 2010-02-09 |
JP4234647B2 (ja) | 2009-03-04 |
BR9813391A (pt) | 2000-10-10 |
AU2158199A (en) | 1999-06-16 |
BR9813391C1 (pt) | 2021-05-25 |
CN1280309C (zh) | 2006-10-18 |
CA2309810A1 (en) | 1999-06-10 |
EP1037921A1 (de) | 2000-09-27 |
JP3673261B2 (ja) | 2005-07-20 |
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