DK1543106T3 - Fremgangsmåder og medier til kontrol af sialylering af proteiner, der dannes af mammaliaceller - Google Patents
Fremgangsmåder og medier til kontrol af sialylering af proteiner, der dannes af mammaliacellerInfo
- Publication number
- DK1543106T3 DK1543106T3 DK03764511T DK03764511T DK1543106T3 DK 1543106 T3 DK1543106 T3 DK 1543106T3 DK 03764511 T DK03764511 T DK 03764511T DK 03764511 T DK03764511 T DK 03764511T DK 1543106 T3 DK1543106 T3 DK 1543106T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- cells
- mammalian cells
- media
- proteins produced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39622102P | 2002-07-15 | 2002-07-15 | |
PCT/US2003/021733 WO2004008100A2 (en) | 2002-07-15 | 2003-07-14 | Methods and media for controlling sialylation of proteins produced by mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1543106T3 true DK1543106T3 (da) | 2007-08-13 |
Family
ID=30115987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03764511T DK1543106T3 (da) | 2002-07-15 | 2003-07-14 | Fremgangsmåder og medier til kontrol af sialylering af proteiner, der dannes af mammaliaceller |
Country Status (15)
Country | Link |
---|---|
US (1) | US7645609B2 (da) |
EP (1) | EP1543106B1 (da) |
JP (1) | JP4510938B2 (da) |
AT (1) | ATE359358T1 (da) |
AU (1) | AU2003249055B2 (da) |
CA (1) | CA2492267C (da) |
CY (1) | CY1107689T1 (da) |
DE (1) | DE60313188T2 (da) |
DK (1) | DK1543106T3 (da) |
ES (1) | ES2285188T3 (da) |
MX (1) | MXPA05000552A (da) |
PL (1) | PL376381A1 (da) |
PT (1) | PT1543106E (da) |
SI (1) | SI1543106T1 (da) |
WO (1) | WO2004008100A2 (da) |
Families Citing this family (59)
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---|---|---|---|---|
JP4496086B2 (ja) † | 2002-12-23 | 2010-07-07 | ブリストル−マイヤーズ スクイブ カンパニー | タンパク質製造のための哺乳類細胞培養方法を用いる生成物品質の増大 |
WO2006044790A2 (en) * | 2004-10-15 | 2006-04-27 | Zymequest, Inc. | Compositions and methods for prolonging survival of platelets |
ES2376777T3 (es) * | 2004-09-07 | 2012-03-16 | Velico Medical, Inc. | Aparato para prolongar la supervivencia de plaquetas |
CA2614039C (en) | 2005-07-22 | 2015-10-13 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
WO2007024743A2 (en) * | 2005-08-19 | 2007-03-01 | Centocor, Inc. | Proteolysis resistant antibody preparations |
EP1954304A4 (en) * | 2005-10-14 | 2010-03-10 | Zymequest Inc | COMPOSITIONS AND METHOD FOR EXTENDING THE LIFE OF PLATES |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
TWI398520B (zh) * | 2005-12-20 | 2013-06-11 | 必治妥美雅史谷比公司 | 組合物及製造組合物之方法 |
US8129145B2 (en) | 2006-07-13 | 2012-03-06 | Wyeth Llc | Production of glycoproteins |
MX346523B (es) | 2006-09-13 | 2017-03-23 | Abbvie Inc | Mejoras de cultivos celulares. |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
WO2008120570A1 (ja) * | 2007-03-19 | 2008-10-09 | National University Corporation Okayama University | タンパク質産生用およびウイルス増殖用の培地 |
TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
US8338569B2 (en) | 2008-08-04 | 2012-12-25 | Five Prime Therapeutics, Inc. | FGFR extracellular domain acidic region muteins |
SG195577A1 (en) | 2008-10-20 | 2013-12-30 | Abbott Lab | Viral inactivation during purification of antibodies |
CN105111309A (zh) | 2008-10-20 | 2015-12-02 | Abbvie公司 | 使用a蛋白亲和层析分离和纯化抗体 |
EP2233502A1 (en) * | 2009-03-27 | 2010-09-29 | Deutsches Rheuma-Forschungszentrum Berlin | Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them |
US8445445B2 (en) | 2009-09-15 | 2013-05-21 | Five Prime Therapeutics, Inc. | Method of promoting hair growth using FGFR4 extracellular domains |
AU2010319327B2 (en) | 2009-11-13 | 2015-08-13 | Five Prime Therapeutics, Inc. | Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2 |
NZ600278A (en) | 2009-11-13 | 2014-04-30 | Grifols Therapeutics Inc | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
EP2325296A1 (en) | 2009-11-20 | 2011-05-25 | LEK Pharmaceuticals d.d. | Production of glycoproteins with low N-glycolylneuraminic acid (Neu5Gc) content |
US8685931B2 (en) | 2009-12-17 | 2014-04-01 | Five Prime Therapeutics, Inc. | Hair growth methods using FGFR3 extracellular domains |
JP6347949B2 (ja) | 2010-04-26 | 2018-06-27 | ノバルティス アーゲー | 改良型細胞培養培地 |
US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
BR112014000352A2 (pt) * | 2011-07-08 | 2017-02-14 | Merck Sharp & Dohe Corp | método de purificar uma proteína de fusão-fc, proteínas de fusão contendo fc purificada, tnfr:fc purificada, e tnfr:fc elevadamente purificada |
WO2013074492A1 (en) | 2011-11-14 | 2013-05-23 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
US20140106405A1 (en) * | 2012-10-15 | 2014-04-17 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
US9499614B2 (en) * | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
TWI771890B (zh) | 2013-03-14 | 2022-07-21 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
JP6689189B2 (ja) | 2013-03-26 | 2020-04-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | タンパク質産生方法 |
US9481901B2 (en) * | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
CN106102749B (zh) * | 2014-03-05 | 2019-07-12 | 奥特吉尼克斯制药公司 | 唾液酸化糖蛋白组合物及其用途 |
JP6652334B2 (ja) * | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
US20160130324A1 (en) | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
BR112018010160A8 (pt) | 2015-11-19 | 2019-02-26 | Shire Human Genetic Therapies | inibidor da c1 esterase humana recombinante e usos do mesmo |
US20220091129A1 (en) * | 2018-12-21 | 2022-03-24 | Jingjie Ptm Biolab (Hangzhou) Co., Inc | Reagents and methods for detecting protein lysine lactylation |
JP2024503239A (ja) | 2020-12-22 | 2024-01-25 | アムジェン インコーポレイテッド | 細胞培養法 |
JP2024509543A (ja) | 2021-03-03 | 2024-03-04 | フォーマイコン アーゲー | ACE2 Fc融合タンパク質の製剤 |
WO2023094507A1 (en) | 2021-11-24 | 2023-06-01 | Formycon Ag | Improved ace2 fusion proteins |
CN114317446B (zh) * | 2021-12-30 | 2023-12-05 | 广州康盛生物科技股份有限公司 | 一种无血清培养基用添加剂及其应用 |
EP4331571A1 (en) | 2022-09-02 | 2024-03-06 | Formycon AG | Formulations of ace2-igm fusion proteins |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672502A (en) * | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
JP3375140B2 (ja) | 1991-03-08 | 2003-02-10 | 森永製菓株式会社 | モノクローナル抗体生産用培地の作製法及びそのキット |
DE69311873T2 (de) * | 1992-05-01 | 1998-02-12 | Teijin Ltd | Fed-batch-Verfahren für Proteine sekretierende Zellen |
JPH06292592A (ja) * | 1993-02-09 | 1994-10-21 | Snow Brand Milk Prod Co Ltd | 糖蛋白質の生産方法 |
US5858783A (en) * | 1993-05-25 | 1999-01-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Production of normal mammalian organ culture using a medium containing mem-alpha, leibovitz L-15, glucose galactose fructose |
ES2264181T3 (es) * | 1997-10-01 | 2006-12-16 | Dsm Ip Assets B.V. | Procedimiento para la produccion de proteinas. |
WO1999028455A1 (de) * | 1997-12-03 | 1999-06-10 | Roche Diagnostics Gmbh | Verfahren zur herstellung von polypeptiden mit geeigneter glykosilierung |
WO1999028346A1 (de) | 1997-12-03 | 1999-06-10 | Roche Diagnostics Gmbh | Erythropoietin mit hoher spezifischer aktivität |
AU5339699A (en) * | 1998-08-06 | 2000-02-28 | Johns Hopkins University School Of Medicine, The | Compounds for altering cell surface sialic acids and methods of use therefor |
DE19852729A1 (de) | 1998-11-16 | 2000-05-18 | Werner Reutter | Rekombinante Glycoproteine, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und ihre Verwendung |
US6949372B2 (en) * | 1999-03-02 | 2005-09-27 | The Johns Hopkins University | Engineering intracellular sialylation pathways |
US6261805B1 (en) * | 1999-07-15 | 2001-07-17 | Boyce Thompson Institute For Plant Research, Inc. | Sialyiation of N-linked glycoproteins in the baculovirus expression vector system |
EP1298217A4 (en) * | 2000-07-05 | 2004-09-08 | Mitsubishi Pharma Corp | GLYCOPROTEIN PRODUCTION PROCESS |
US20040214228A9 (en) * | 2001-09-14 | 2004-10-28 | Ganesh Venkataraman | Methods of evaluating glycomolecules for enhanced activities |
JP4281797B2 (ja) | 2006-12-21 | 2009-06-17 | 三菱自動車工業株式会社 | 車両の車体構造 |
-
2003
- 2003-07-14 MX MXPA05000552A patent/MXPA05000552A/es active IP Right Grant
- 2003-07-14 ES ES03764511T patent/ES2285188T3/es not_active Expired - Lifetime
- 2003-07-14 WO PCT/US2003/021733 patent/WO2004008100A2/en active IP Right Grant
- 2003-07-14 PL PL03376381A patent/PL376381A1/xx not_active Application Discontinuation
- 2003-07-14 AU AU2003249055A patent/AU2003249055B2/en not_active Expired
- 2003-07-14 CA CA2492267A patent/CA2492267C/en not_active Expired - Lifetime
- 2003-07-14 EP EP03764511A patent/EP1543106B1/en not_active Expired - Lifetime
- 2003-07-14 DK DK03764511T patent/DK1543106T3/da active
- 2003-07-14 SI SI200330783T patent/SI1543106T1/sl unknown
- 2003-07-14 AT AT03764511T patent/ATE359358T1/de not_active IP Right Cessation
- 2003-07-14 DE DE60313188T patent/DE60313188T2/de not_active Expired - Lifetime
- 2003-07-14 JP JP2004521682A patent/JP4510938B2/ja not_active Expired - Lifetime
- 2003-07-14 PT PT03764511T patent/PT1543106E/pt unknown
- 2003-07-15 US US10/620,064 patent/US7645609B2/en not_active Expired - Lifetime
-
2007
- 2007-07-02 CY CY20071100866T patent/CY1107689T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2492267C (en) | 2013-09-10 |
ATE359358T1 (de) | 2007-05-15 |
AU2003249055A1 (en) | 2004-02-02 |
US20040115768A1 (en) | 2004-06-17 |
EP1543106A2 (en) | 2005-06-22 |
EP1543106A4 (en) | 2005-08-10 |
JP2005532813A (ja) | 2005-11-04 |
SI1543106T1 (sl) | 2007-08-31 |
JP4510938B2 (ja) | 2010-07-28 |
AU2003249055B2 (en) | 2008-06-26 |
CA2492267A1 (en) | 2004-01-22 |
CY1107689T1 (el) | 2013-04-18 |
MXPA05000552A (es) | 2005-04-28 |
WO2004008100A2 (en) | 2004-01-22 |
WO2004008100A3 (en) | 2004-03-25 |
DE60313188D1 (de) | 2007-05-24 |
EP1543106B1 (en) | 2007-04-11 |
PT1543106E (pt) | 2007-05-31 |
PL376381A1 (en) | 2005-12-27 |
ES2285188T3 (es) | 2007-11-16 |
US7645609B2 (en) | 2010-01-12 |
DE60313188T2 (de) | 2007-12-20 |
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