DE60138127D1 - Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine - Google Patents

Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine

Info

Publication number
DE60138127D1
DE60138127D1 DE60138127T DE60138127T DE60138127D1 DE 60138127 D1 DE60138127 D1 DE 60138127D1 DE 60138127 T DE60138127 T DE 60138127T DE 60138127 T DE60138127 T DE 60138127T DE 60138127 D1 DE60138127 D1 DE 60138127D1
Authority
DE
Germany
Prior art keywords
host cells
recombinant host
polypeptide
fertilizers
recombinant proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138127T
Other languages
English (en)
Inventor
Dana Andersen
John Joly
Bradley R Snedecor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22928808&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60138127(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE60138127D1 publication Critical patent/DE60138127D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fertilizers (AREA)
DE60138127T 2000-11-03 2001-11-01 Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine Expired - Lifetime DE60138127D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24596200P 2000-11-03 2000-11-03
PCT/US2001/045623 WO2002040697A2 (en) 2000-11-03 2001-11-01 Metabolic rate shifts in fermentations expressing recombinant proteins

Publications (1)

Publication Number Publication Date
DE60138127D1 true DE60138127D1 (de) 2009-05-07

Family

ID=22928808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60138127T Expired - Lifetime DE60138127D1 (de) 2000-11-03 2001-11-01 Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine

Country Status (14)

Country Link
US (1) US6716602B2 (de)
EP (1) EP1332222B1 (de)
JP (1) JP4878724B2 (de)
AT (1) ATE426674T1 (de)
AU (1) AU3944002A (de)
CA (1) CA2426100A1 (de)
CY (1) CY1110494T1 (de)
DE (1) DE60138127D1 (de)
DK (1) DK1332222T3 (de)
ES (1) ES2324645T3 (de)
HK (1) HK1054765A1 (de)
IL (2) IL155482A0 (de)
PT (1) PT1332222E (de)
WO (1) WO2002040697A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
JP2005528112A (ja) * 2002-05-30 2005-09-22 カーギル ダウ エルエルシー 酵母におけるｄ−乳酸の生産方法およびその材料
GB0321100D0 (en) * 2003-09-09 2003-10-08 Celltech R&D Ltd Biological products
US20110269233A1 (en) 2008-09-15 2011-11-03 Laetitia Malphettes Compositions and methods for regulating cell osmolarity
PL2493922T3 (pl) 2009-10-26 2017-07-31 F.Hoffmann-La Roche Ag Sposób wytwarzania glikozylowanych immunoglobulin
GB2482536B (en) 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
AR092630A1 (es) 2012-09-19 2015-04-29 Genentech Inc Metodos y composiciones para prevenir la incorporacion erronea de norleucina en proteinas
EP3030671B1 (de) 2013-08-05 2018-10-03 Greenlight Biosciences, Inc. Manipulierte proteine mit einer proteaseschnittstelle
EP3147369A4 (de) * 2014-05-21 2018-02-07 Ajinomoto Co., Inc. Verfahren zur herstellung eines fibroinartigen proteins
CN104164465B (zh) * 2014-07-14 2017-07-04 北京泰德制药股份有限公司 一种表达重组蛋白的发酵工艺
KR20170075793A (ko) * 2014-11-05 2017-07-03 제넨테크, 인크. 박테리아 내 2쇄 단백질을 생산하는 방법
AU2015342964B2 (en) 2014-11-05 2021-06-24 Genentech, Inc. Methods of producing two chain proteins in bacteria
US11225678B2 (en) * 2015-05-29 2022-01-18 Cargill, Incorporated Fermentation methods for producing steviol glycosides with multi-phase feeding
AU2016271125A1 (en) 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
CA2987585C (en) 2015-05-29 2023-08-29 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high ph and compositions obtained therefrom
JP2018521680A (ja) 2015-08-06 2018-08-09 カーギル・インコーポレイテッド ステビオール配糖体を生成するための発酵法
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
US11261462B2 (en) 2016-01-27 2022-03-01 Just-Evotec Biologics, Inc. Inducible expression from transposon-based vectors and uses
US11098310B2 (en) 2016-01-27 2021-08-24 Just-Evotec Biologics, Inc. Expression from transposon-based vectors and uses
US11028410B2 (en) 2016-01-27 2021-06-08 Just-Evotec Biologics, Inc. Hybrid promoter and uses thereof
NZ758485A (en) 2017-04-27 2024-02-23 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565785A (en) 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4673641A (en) 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4738921A (en) 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4795706A (en) 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5342763A (en) 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
CA2153445C (en) * 1994-09-08 2002-05-21 Ashok Raj Saxena Video optimized media streamer user interface
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
US5790423A (en) * 1995-06-14 1998-08-04 Audible, Inc. Interactive audio transmission receiving and playback system
AR005035A1 (es) 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
US6615192B1 (en) * 1999-03-12 2003-09-02 Matsushita Electric Industrial Co., Ltd. Contents copying system, copying method, computer-readable recording medium and disc drive copying contents but not a cipher key via a host computer
ID27746A (id) * 1999-05-28 2001-04-26 Matsushita Electric Ind Co Ltd Kartu semikonduktor, peralatan playback, peralatan perekaman, metoda playback, metoda perekaman, dan media perekaman dapat dibaca kombuter
DE19943919B4 (de) * 1999-09-14 2004-05-27 Pharmacia Ab Verfahren zur Steigerung der Ausbeute von rekombinanten Proteinen in mikrobiellen Fermentationsprozessen

Also Published As

Publication number Publication date
DK1332222T3 (da) 2009-07-06
US20020164700A1 (en) 2002-11-07
JP4878724B2 (ja) 2012-02-15
CA2426100A1 (en) 2002-05-23
AU3944002A (en) 2002-05-27
IL155482A (en) 2010-12-30
WO2002040697A3 (en) 2003-03-13
US6716602B2 (en) 2004-04-06
WO2002040697A2 (en) 2002-05-23
CY1110494T1 (el) 2015-04-29
PT1332222E (pt) 2009-06-30
EP1332222A2 (de) 2003-08-06
ES2324645T3 (es) 2009-08-12
JP2004517614A (ja) 2004-06-17
ATE426674T1 (de) 2009-04-15
IL155482A0 (en) 2003-11-23
HK1054765A1 (en) 2003-12-12
EP1332222B1 (de) 2009-03-25

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