TR200000058T2 - Benzotiyofen türevleri-kullanım ve terkipleri. - Google Patents

Benzotiyofen türevleri-kullanım ve terkipleri.

Info

Publication number
TR200000058T2
TR200000058T2 TR2000/00058T TR200000058T TR200000058T2 TR 200000058 T2 TR200000058 T2 TR 200000058T2 TR 2000/00058 T TR2000/00058 T TR 2000/00058T TR 200000058 T TR200000058 T TR 200000058T TR 200000058 T2 TR200000058 T2 TR 200000058T2
Authority
TR
Turkey
Prior art keywords
alkyl
co2r8
nr9r10
halogen
usage
Prior art date
Application number
TR2000/00058T
Other languages
English (en)
Inventor
Monge Vega Antonio
Del Rio Zambrana Joaquin
Lasheras Aldaz Berta
Antonio Palop Cubillo Juan
Bosch Rovira Anna
Carlos Del Castillo Nieto Juan
Roca Acin Juan
Original Assignee
Vita-Invest, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita-Invest, S.A. filed Critical Vita-Invest, S.A.
Publication of TR200000058T2 publication Critical patent/TR200000058T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Z' nin -CO-, -CH(OR6)-,-C(NOR7)-, R1 in H., C1-C6 alkil, halojen veya OR8;R2 ve R3 ün H, alkil, halojen, OR8, nitro, siano, NR9R10; -COR8; CO2R8; -SO2NR9R10; -SO2R8; -SR8; -CONR9R19; R4 ve R5 in H, alkil, halojen, haloalkil, -OR8, nitro, NR9R10; -COR8; CO2R8; -SO2NR9R10; -SO2R8; SR8, siano; -CONR9R10 oldugu veya R4 ve R4 ve R5' in bir benzen halkasi olusturdugu; R6' nin H, alkil, CO2R8, -C(O)NR9R10, naftil veya fenil; R7'nin H veya alkil;R82in H, C1-C6 alkil veya fenil;R9 ve R 10'un H, alkil veya fenil oldugu R9 ve R10' un 5- veya 6-elementli bir halka olusturdugu formül (I): Formül (I) Benzotiyofen bilesimleri ve bu bilesimlerin uygun kullanimi ve terkibi. Bu bilesimler anksiyete veya depresyon tedavisinde etkilidir.
TR2000/00058T 1997-07-08 1998-07-01 Benzotiyofen türevleri-kullanım ve terkipleri. TR200000058T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701517A ES2128266B1 (es) 1997-07-08 1997-07-08 Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Publications (1)

Publication Number Publication Date
TR200000058T2 true TR200000058T2 (tr) 2000-09-21

Family

ID=8299986

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00058T TR200000058T2 (tr) 1997-07-08 1998-07-01 Benzotiyofen türevleri-kullanım ve terkipleri.

Country Status (21)

Country Link
US (1) US6262056B1 (tr)
EP (1) EP1008594B1 (tr)
JP (1) JP2002511883A (tr)
KR (1) KR20010021632A (tr)
CN (1) CN1125821C (tr)
AT (1) ATE261956T1 (tr)
AU (1) AU735637B2 (tr)
BR (1) BR9810557A (tr)
CA (1) CA2295715A1 (tr)
DE (1) DE69822478D1 (tr)
EA (1) EA002687B1 (tr)
ES (1) ES2128266B1 (tr)
HU (1) HUP0002861A3 (tr)
IL (1) IL133566A (tr)
IS (1) IS5328A (tr)
NZ (1) NZ502128A (tr)
OA (1) OA11274A (tr)
PL (1) PL337930A1 (tr)
SK (1) SK272000A3 (tr)
TR (1) TR200000058T2 (tr)
WO (1) WO1999002516A1 (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6050500A (en) * 1999-07-21 2001-02-13 Eli Lilly And Company Benzothiophene derivatives
EP1246816B1 (en) * 1999-12-30 2004-03-17 H. Lundbeck A/S Substituted phenyl-piperazine derivatives, their preparation and use
DE10043659A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazinderivate
ES2188344B1 (es) * 2000-11-29 2004-09-16 Laboratorios Vita, S.A. Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
NZ541009A (en) 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof
WO2004082686A2 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AU2008251259B2 (en) * 2007-05-14 2013-02-14 Sk Biopharmaceuticals Co., Ltd. Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
CN101613347B (zh) * 2008-06-23 2012-07-04 中国人民解放军军事医学科学院毒物药物研究所 胺类化合物及其医药用途
CN101619056B (zh) * 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
US9273027B2 (en) * 2010-02-24 2016-03-01 Research Triangle Institute Arylpiperazine opioid receptor antagonists
WO2015090235A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
WO2021152113A1 (en) 2020-01-31 2021-08-05 Bayer Aktiengesellschaft Substituted 2,3-benzodiazepines derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2979507A (en) * 1959-03-26 1961-04-11 Paul Adriaan J Janssen 1-(2-thenoyl) alkyl-4-arylpiperazines
US3002976A (en) * 1959-10-12 1961-10-03 Paul A J Janssen 1-(2-thienyl)-omega-(4-arylpiperazine)alkanols
GB1096341A (en) * 1965-03-09 1967-12-29 Mauvernay Roland Yves Novel derivatives of the phenyl-piperazine series and process for their preparation
US4515793A (en) * 1983-07-27 1985-05-07 Edna Mcconnell Clark Foundation Phenylpiperazines which are useful in the treatment of schistosomiasis
US5466691A (en) * 1991-08-09 1995-11-14 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compound
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5632898A (en) * 1996-08-13 1997-05-27 Isis Pharmaceuticals, Inc. Method for removing unreacted electrophiles from a reaction mixture

Also Published As

Publication number Publication date
NZ502128A (en) 2001-09-28
US6262056B1 (en) 2001-07-17
HUP0002861A3 (en) 2001-09-28
KR20010021632A (ko) 2001-03-15
EP1008594B1 (en) 2004-03-17
AU735637B2 (en) 2001-07-12
IS5328A (is) 1999-12-29
EA200000101A1 (ru) 2000-08-28
ES2128266A1 (es) 1999-05-01
JP2002511883A (ja) 2002-04-16
ATE261956T1 (de) 2004-04-15
HUP0002861A2 (hu) 2001-08-28
BR9810557A (pt) 2000-08-08
IL133566A0 (en) 2001-04-30
EP1008594A1 (en) 2000-06-14
IL133566A (en) 2003-10-31
PL337930A1 (en) 2000-09-11
OA11274A (en) 2003-07-29
SK272000A3 (en) 2000-07-11
EA002687B1 (ru) 2002-08-29
WO1999002516A1 (es) 1999-01-21
DE69822478D1 (de) 2004-04-22
ES2128266B1 (es) 2000-01-16
CN1265106A (zh) 2000-08-30
CN1125821C (zh) 2003-10-29
CA2295715A1 (en) 1999-01-21
AU8111398A (en) 1999-02-08

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