HUP0100704A2 - Alfa 1A receptor antagonista ftálimido arilpiperazinok, amelyek jóindulatú prosztata hiperplázia kezelésére alkalmasak - Google Patents
Alfa 1A receptor antagonista ftálimido arilpiperazinok, amelyek jóindulatú prosztata hiperplázia kezelésére alkalmasakInfo
- Publication number
- HUP0100704A2 HUP0100704A2 HU0100704A HUP0100704A HUP0100704A2 HU P0100704 A2 HUP0100704 A2 HU P0100704A2 HU 0100704 A HU0100704 A HU 0100704A HU P0100704 A HUP0100704 A HU P0100704A HU P0100704 A2 HUP0100704 A2 HU P0100704A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- phenyl
- treatment
- benign prostatic
- prostatic hyperplasia
- Prior art date
Links
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title abstract 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title abstract 3
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgya jóindulatú prosztata hiperplázia kezelésérealkalmazható ftálimido arilpiperazin alfa1a receptor antagonisták. Atalálmány (I) általános képletű heterociklusos szubsztituáltpiperazinokra, a vegyületeket tartalmazó gyógyászati készítményekre ésaz előállításukhoz használt intermedierekre vonatkozik. A találmányszerinti vegyületek szelektív gátolják az a1a adrenerg receptorhozvaló kötődést. Ez a receptor a jóindulatú prosztata hiperpláziábanjátszik szerepet. A vegyületek ezen betegség kezelésére alkalmazhatók.Az (I) általános képletben a szubsztituensek jelentése az alábbiakbanmegadott: R1 jelentése hidrogén- vagy halogénatom, 1-5 szénatomosalkoxi-, hidroxil- vagy 1-5 szénatomos alkilcsoport; R2 jelentéseadott esetben helyettesített 1-6 szénatomos alkil-, fenil- vagyfenil(1-5 szénatomos alkil)-csoport; R3 jelentése hidrogénatom,hidroxil- vagy 1-5 szénatomos alkoxicsoport; R4 jelentésehidrogénatom, 1-5 szénatomos alkil-, fenil- vagy fenil-(1-5 szénatomosalkil)-csoport; R5, R6 és R7 jelentése hidrogén- vagy halogénatom,hidroxil- vagy adott esetben szubsztituált 1-8 szénatomosalkilcsoport, vagy 1-5 szénatomos alkoxi-, amino, alkilkarbonil- vagyalkoxi-karbonilcsoport; A,B,E jelentése Nitrogén - vagy szénatom,azzal a megkötéssel, hogy közülük csak az egyik nitrogénatom. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7551098P | 1998-02-20 | 1998-02-20 | |
| PCT/US1999/003694 WO1999042445A1 (en) | 1998-02-20 | 1999-02-19 | Phtalimido arylpiperazines as alpha 1a receptor antagonists useful in the treatment of benign prostatic hyperplasia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100704A2 true HUP0100704A2 (hu) | 2001-10-28 |
| HUP0100704A3 HUP0100704A3 (en) | 2002-10-28 |
Family
ID=22126243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100704A HUP0100704A3 (en) | 1998-02-20 | 1999-02-19 | Phtalimido arylpiperazines as alpha 1a receptor antagonists useful in the treatment of benign prostatic hyperplasia |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20020077476A1 (hu) |
| EP (1) | EP1056720B1 (hu) |
| JP (1) | JP2002503722A (hu) |
| KR (1) | KR100608473B1 (hu) |
| CN (1) | CN1172911C (hu) |
| AR (1) | AR015521A1 (hu) |
| AT (1) | ATE280156T1 (hu) |
| AU (1) | AU766411B2 (hu) |
| BR (1) | BR9908122A (hu) |
| DE (1) | DE69921300T2 (hu) |
| ES (1) | ES2233023T3 (hu) |
| HK (1) | HK1031872A1 (hu) |
| HU (1) | HUP0100704A3 (hu) |
| IL (2) | IL137953A0 (hu) |
| NO (1) | NO317104B1 (hu) |
| NZ (1) | NZ506461A (hu) |
| PL (1) | PL194649B1 (hu) |
| PT (1) | PT1056720E (hu) |
| TR (1) | TR200003224T2 (hu) |
| WO (1) | WO1999042445A1 (hu) |
| ZA (1) | ZA991319B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20010164A1 (it) * | 2001-01-30 | 2002-07-30 | Recordati Chem Pharm | Alfa 1 antagonisti selettivi a + d |
| CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
| HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
| CN106966940B (zh) * | 2015-07-30 | 2019-03-19 | 新发药业有限公司 | 一种西他列汀磷酸盐中间体n-芳甲基-2s-氰基甲基吖啶的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1382742A (en) | 1972-09-19 | 1975-02-05 | Labaz | Benzofuran derivatives and process for preparing the same |
| CH585693A5 (hu) | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| HU177702B (en) | 1977-10-24 | 1981-12-28 | Noevenyvedelmi Kutato Intezet | Plant growth regulator and process for preparing the active materials |
| PT82077B (fr) * | 1985-02-26 | 1987-09-25 | Sanofi Sa | Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides |
| FR2678271B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
| EA001904B1 (ru) * | 1997-05-12 | 2001-10-22 | ОРТО МакНЕЙЛ ФАРМАСЬЮТИКАЛ, ИНК. | Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты |
-
1999
- 1999-02-18 ZA ZA9901319A patent/ZA991319B/xx unknown
- 1999-02-19 NZ NZ506461A patent/NZ506461A/en unknown
- 1999-02-19 DE DE69921300T patent/DE69921300T2/de not_active Expired - Fee Related
- 1999-02-19 PT PT99908303T patent/PT1056720E/pt unknown
- 1999-02-19 AT AT99908303T patent/ATE280156T1/de not_active IP Right Cessation
- 1999-02-19 KR KR1020007009159A patent/KR100608473B1/ko not_active IP Right Cessation
- 1999-02-19 BR BR9908122-9A patent/BR9908122A/pt not_active Application Discontinuation
- 1999-02-19 JP JP2000532397A patent/JP2002503722A/ja not_active Withdrawn
- 1999-02-19 WO PCT/US1999/003694 patent/WO1999042445A1/en active IP Right Grant
- 1999-02-19 EP EP99908303A patent/EP1056720B1/en not_active Expired - Lifetime
- 1999-02-19 CN CNB998030260A patent/CN1172911C/zh not_active Expired - Fee Related
- 1999-02-19 ES ES99908303T patent/ES2233023T3/es not_active Expired - Lifetime
- 1999-02-19 AU AU27765/99A patent/AU766411B2/en not_active Ceased
- 1999-02-19 HU HU0100704A patent/HUP0100704A3/hu unknown
- 1999-02-19 PL PL99342357A patent/PL194649B1/pl not_active IP Right Cessation
- 1999-02-19 TR TR2000/03224T patent/TR200003224T2/xx unknown
- 1999-02-19 IL IL13795399A patent/IL137953A0/xx active IP Right Grant
- 1999-02-23 AR ARP990100676A patent/AR015521A1/es active IP Right Grant
-
2000
- 2000-08-18 IL IL137953A patent/IL137953A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004142A patent/NO317104B1/no not_active IP Right Cessation
-
2001
- 2001-04-03 HK HK01102397A patent/HK1031872A1/xx not_active IP Right Cessation
- 2001-12-11 US US10/014,979 patent/US20020077476A1/en not_active Abandoned
-
2002
- 2002-07-29 US US10/207,473 patent/US6780994B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999042445A1 (en) | 1999-08-26 |
| ES2233023T3 (es) | 2005-06-01 |
| EP1056720A1 (en) | 2000-12-06 |
| US20020077476A1 (en) | 2002-06-20 |
| US6780994B2 (en) | 2004-08-24 |
| IL137953A0 (en) | 2001-10-31 |
| ATE280156T1 (de) | 2004-11-15 |
| NZ506461A (en) | 2003-08-29 |
| DE69921300D1 (de) | 2004-11-25 |
| EP1056720B1 (en) | 2004-10-20 |
| CN1172911C (zh) | 2004-10-27 |
| ZA991319B (en) | 2000-11-20 |
| IL137953A (en) | 2006-12-31 |
| PL342357A1 (en) | 2001-06-04 |
| BR9908122A (pt) | 2001-11-13 |
| DE69921300T2 (de) | 2006-03-09 |
| NO317104B1 (no) | 2004-08-09 |
| KR20010041118A (ko) | 2001-05-15 |
| KR100608473B1 (ko) | 2006-08-09 |
| US20030088099A1 (en) | 2003-05-08 |
| NO20004142D0 (no) | 2000-08-18 |
| HK1031872A1 (en) | 2001-06-29 |
| CN1291185A (zh) | 2001-04-11 |
| HUP0100704A3 (en) | 2002-10-28 |
| NO20004142L (no) | 2000-10-19 |
| AU766411B2 (en) | 2003-10-16 |
| PT1056720E (pt) | 2005-02-28 |
| TR200003224T2 (tr) | 2001-03-21 |
| AR015521A1 (es) | 2001-05-02 |
| AU2776599A (en) | 1999-09-06 |
| JP2002503722A (ja) | 2002-02-05 |
| PL194649B1 (pl) | 2007-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |