AR015521A1 - Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen. - Google Patents
Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen.Info
- Publication number
- AR015521A1 AR015521A1 ARP990100676A ARP990100676A AR015521A1 AR 015521 A1 AR015521 A1 AR 015521A1 AR P990100676 A ARP990100676 A AR P990100676A AR P990100676 A ARP990100676 A AR P990100676A AR 015521 A1 AR015521 A1 AR 015521A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- independently selected
- substituted
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Ftalimido arilpiperazinas de la formula I en donde: R1 es hidrogeno, halogeno, alcoxi C1-5, hidroxilo o alquilo C1-5, R2 es alquilo C1-6, alquilo C1-6sustituido donde los sustituyentes de alquilo son independientemente seleccionados entre uno o másh alogenos, fenilo, fenilo sustituido donde los sustituyentesde fenilo son independientemente seleccionados entre uno o más miembros del grupo que consiste de alquilo C1-5, alcoxi C1-5 y trihaloalquiloC1-5, fenilalquiloC1-5, o fenilalquilo C1-5sustitu ido donde los sustituyentes de fenilo se seleccionan independientemente entre uno o más miembros del grupo que consiste dealquiloC1-5, halogeno, alcoxiC1-5 y trihaloalquiloC1-5; R3 es hidrogeno, hidroxi, o alcoxiC1-5, si la línea punteadaestá ausent e, o es oxígeno si la líneapunteada está presente; R4 es hidrogeno, alquilo C1-5, fenilalquilo C1-5 o fenilalquiloC1-5 sustituido, donde los sustituyentes de fenilo se seleccionanindependientemente entre uno o más miembros del grupo queconsiste de a lquilo C1-5, alcoxiC1-5 y trihaloalquiloC1-5; R5 es hidrogeno, halogeno, hidroxi,alquiloC1-8, alquiloC1-8 sustituido donde los sustituyentes de alquilo se seleccionan independientemente entre uno o más halogenos, alcoxiC1-5, amino,alquilC1-5amino, d ialquilC1-5amino, alquilC1-5carbonilo, alcoxiC1-5caarbonilo, nitrilo, o nitro; R6 es hidrogeno, halogeno, hidroxi, alquiloC1-8, alquiloC1-8sustituido donde los sustituyentes de alquilo se seleccionan independientemente entre uno omás halogenos, alco xiC1-5, amino, alquilC1-amino, dialquilC1-5amino, alquilC1-5carbonilo, alcoxiC1-5carbonilo, o nitro; A es nitrogeno o carbono; B es nitrogeno o carbono; E es nitrogeno o carbono; con la condicion de que solouno de A, B o E esnitrogeno; sales farmacé uticamente aceptables del mismo; y esteroisomeros, mezclas racémicas, así comotambién enentiomeros del mismo;composiciones farmacéuticas que los contienen, su uso para la fabricacion de un medicamento, procedimientos para supreparacion y compuestos para su exclusivouso en dichos procedimientos. Dichos compuestos inhiben selectivamente el enlace al receptor adrenérgico alfa1a, un receptor que ha sido involucrado en
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7551098P | 1998-02-20 | 1998-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015521A1 true AR015521A1 (es) | 2001-05-02 |
Family
ID=22126243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100676A AR015521A1 (es) | 1998-02-20 | 1999-02-23 | Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20020077476A1 (es) |
| EP (1) | EP1056720B1 (es) |
| JP (1) | JP2002503722A (es) |
| KR (1) | KR100608473B1 (es) |
| CN (1) | CN1172911C (es) |
| AR (1) | AR015521A1 (es) |
| AT (1) | ATE280156T1 (es) |
| AU (1) | AU766411B2 (es) |
| BR (1) | BR9908122A (es) |
| DE (1) | DE69921300T2 (es) |
| ES (1) | ES2233023T3 (es) |
| HK (1) | HK1031872A1 (es) |
| HU (1) | HUP0100704A3 (es) |
| IL (2) | IL137953A0 (es) |
| NO (1) | NO317104B1 (es) |
| NZ (1) | NZ506461A (es) |
| PL (1) | PL194649B1 (es) |
| PT (1) | PT1056720E (es) |
| TR (1) | TR200003224T2 (es) |
| WO (1) | WO1999042445A1 (es) |
| ZA (1) | ZA991319B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20010164A1 (it) * | 2001-01-30 | 2002-07-30 | Recordati Chem Pharm | Alfa 1 antagonisti selettivi a + d |
| CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
| HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
| CN106966940B (zh) * | 2015-07-30 | 2019-03-19 | 新发药业有限公司 | 一种西他列汀磷酸盐中间体n-芳甲基-2s-氰基甲基吖啶的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1382742A (en) | 1972-09-19 | 1975-02-05 | Labaz | Benzofuran derivatives and process for preparing the same |
| CH585693A5 (es) | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| HU177702B (en) | 1977-10-24 | 1981-12-28 | Noevenyvedelmi Kutato Intezet | Plant growth regulator and process for preparing the active materials |
| PT82077B (fr) * | 1985-02-26 | 1987-09-25 | Sanofi Sa | Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides |
| FR2678271B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
| EA001904B1 (ru) * | 1997-05-12 | 2001-10-22 | ОРТО МакНЕЙЛ ФАРМАСЬЮТИКАЛ, ИНК. | Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты |
-
1999
- 1999-02-18 ZA ZA9901319A patent/ZA991319B/xx unknown
- 1999-02-19 NZ NZ506461A patent/NZ506461A/en unknown
- 1999-02-19 DE DE69921300T patent/DE69921300T2/de not_active Expired - Fee Related
- 1999-02-19 PT PT99908303T patent/PT1056720E/pt unknown
- 1999-02-19 AT AT99908303T patent/ATE280156T1/de not_active IP Right Cessation
- 1999-02-19 KR KR1020007009159A patent/KR100608473B1/ko not_active IP Right Cessation
- 1999-02-19 BR BR9908122-9A patent/BR9908122A/pt not_active Application Discontinuation
- 1999-02-19 JP JP2000532397A patent/JP2002503722A/ja not_active Withdrawn
- 1999-02-19 WO PCT/US1999/003694 patent/WO1999042445A1/en active IP Right Grant
- 1999-02-19 EP EP99908303A patent/EP1056720B1/en not_active Expired - Lifetime
- 1999-02-19 CN CNB998030260A patent/CN1172911C/zh not_active Expired - Fee Related
- 1999-02-19 ES ES99908303T patent/ES2233023T3/es not_active Expired - Lifetime
- 1999-02-19 AU AU27765/99A patent/AU766411B2/en not_active Ceased
- 1999-02-19 HU HU0100704A patent/HUP0100704A3/hu unknown
- 1999-02-19 PL PL99342357A patent/PL194649B1/pl not_active IP Right Cessation
- 1999-02-19 TR TR2000/03224T patent/TR200003224T2/xx unknown
- 1999-02-19 IL IL13795399A patent/IL137953A0/xx active IP Right Grant
- 1999-02-23 AR ARP990100676A patent/AR015521A1/es active IP Right Grant
-
2000
- 2000-08-18 IL IL137953A patent/IL137953A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004142A patent/NO317104B1/no not_active IP Right Cessation
-
2001
- 2001-04-03 HK HK01102397A patent/HK1031872A1/xx not_active IP Right Cessation
- 2001-12-11 US US10/014,979 patent/US20020077476A1/en not_active Abandoned
-
2002
- 2002-07-29 US US10/207,473 patent/US6780994B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999042445A1 (en) | 1999-08-26 |
| ES2233023T3 (es) | 2005-06-01 |
| EP1056720A1 (en) | 2000-12-06 |
| US20020077476A1 (en) | 2002-06-20 |
| HUP0100704A2 (hu) | 2001-10-28 |
| US6780994B2 (en) | 2004-08-24 |
| IL137953A0 (en) | 2001-10-31 |
| ATE280156T1 (de) | 2004-11-15 |
| NZ506461A (en) | 2003-08-29 |
| DE69921300D1 (de) | 2004-11-25 |
| EP1056720B1 (en) | 2004-10-20 |
| CN1172911C (zh) | 2004-10-27 |
| ZA991319B (en) | 2000-11-20 |
| IL137953A (en) | 2006-12-31 |
| PL342357A1 (en) | 2001-06-04 |
| BR9908122A (pt) | 2001-11-13 |
| DE69921300T2 (de) | 2006-03-09 |
| NO317104B1 (no) | 2004-08-09 |
| KR20010041118A (ko) | 2001-05-15 |
| KR100608473B1 (ko) | 2006-08-09 |
| US20030088099A1 (en) | 2003-05-08 |
| NO20004142D0 (no) | 2000-08-18 |
| HK1031872A1 (en) | 2001-06-29 |
| CN1291185A (zh) | 2001-04-11 |
| HUP0100704A3 (en) | 2002-10-28 |
| NO20004142L (no) | 2000-10-19 |
| AU766411B2 (en) | 2003-10-16 |
| PT1056720E (pt) | 2005-02-28 |
| TR200003224T2 (tr) | 2001-03-21 |
| AU2776599A (en) | 1999-09-06 |
| JP2002503722A (ja) | 2002-02-05 |
| PL194649B1 (pl) | 2007-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |