BR9908122A - Ftalmido arilpiperazinas comoantagonistas de receptor alfa 1a úteis notratamento de hiperplasia prostática benigna - Google Patents

Ftalmido arilpiperazinas comoantagonistas de receptor alfa 1a úteis notratamento de hiperplasia prostática benigna

Info

Publication number
BR9908122A
BR9908122A BR9908122-9A BR9908122A BR9908122A BR 9908122 A BR9908122 A BR 9908122A BR 9908122 A BR9908122 A BR 9908122A BR 9908122 A BR9908122 A BR 9908122A
Authority
BR
Brazil
Prior art keywords
prostatic hyperplasia
treatment
benign prostatic
phthalmide
arylpiperazines
Prior art date
Application number
BR9908122-9A
Other languages
English (en)
Inventor
Gee-Hong Kuo
William V Murray
Catherine P Prouty
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR9908122A publication Critical patent/BR9908122A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

Patente de Invenção: "FTALMIDO ARILPIPERAZINAS COMOANTAGONISTAS DE RECEPTOR ALFA 1A úTEIS NOTRATAMENTO DE HIPERPLASIA PROSTáTICA BENIGNA".Esta invenção refere-se a uma série de piperazinas substituídasheterocíclicas de Fórmula (I), composições farmacêuticascontendo-as e intermediários empregados em sua fabricação. Oscompostos da invenção seletivamente inibem a ligação ao receptoradrenérgico <244>-1a, um receptor que tem sido implicado emhiperplasia prostática benigna. Como tal os compostos sãopotencialmente úteis no tratamento desta doença.
BR9908122-9A 1998-02-20 1999-02-19 Ftalmido arilpiperazinas comoantagonistas de receptor alfa 1a úteis notratamento de hiperplasia prostática benigna BR9908122A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7551098P 1998-02-20 1998-02-20
PCT/US1999/003694 WO1999042445A1 (en) 1998-02-20 1999-02-19 Phtalimido arylpiperazines as alpha 1a receptor antagonists useful in the treatment of benign prostatic hyperplasia

Publications (1)

Publication Number Publication Date
BR9908122A true BR9908122A (pt) 2001-11-13

Family

ID=22126243

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908122-9A BR9908122A (pt) 1998-02-20 1999-02-19 Ftalmido arilpiperazinas comoantagonistas de receptor alfa 1a úteis notratamento de hiperplasia prostática benigna

Country Status (21)

Country Link
US (2) US20020077476A1 (pt)
EP (1) EP1056720B1 (pt)
JP (1) JP2002503722A (pt)
KR (1) KR100608473B1 (pt)
CN (1) CN1172911C (pt)
AR (1) AR015521A1 (pt)
AT (1) ATE280156T1 (pt)
AU (1) AU766411B2 (pt)
BR (1) BR9908122A (pt)
DE (1) DE69921300T2 (pt)
ES (1) ES2233023T3 (pt)
HK (1) HK1031872A1 (pt)
HU (1) HUP0100704A3 (pt)
IL (2) IL137953A0 (pt)
NO (1) NO317104B1 (pt)
NZ (1) NZ506461A (pt)
PL (1) PL194649B1 (pt)
PT (1) PT1056720E (pt)
TR (1) TR200003224T2 (pt)
WO (1) WO1999042445A1 (pt)
ZA (1) ZA991319B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20010164A1 (it) * 2001-01-30 2002-07-30 Recordati Chem Pharm Alfa 1 antagonisti selettivi a + d
CN103387531A (zh) * 2012-05-10 2013-11-13 广州医学院 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
CN106966940B (zh) * 2015-07-30 2019-03-19 新发药业有限公司 一种西他列汀磷酸盐中间体n-芳甲基-2s-氰基甲基吖啶的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382742A (en) 1972-09-19 1975-02-05 Labaz Benzofuran derivatives and process for preparing the same
CH585693A5 (pt) 1974-02-08 1977-03-15 Ciba Geigy Ag
HU177702B (en) 1977-10-24 1981-12-28 Noevenyvedelmi Kutato Intezet Plant growth regulator and process for preparing the active materials
PT82077B (fr) * 1985-02-26 1987-09-25 Sanofi Sa Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
HUP0100048A3 (en) * 1997-05-12 2002-12-28 Ortho Mcneil Pharm Inc Arylsubstituted piperazine-derivatives, useful in the treatement of benign prostatic hyperlasia use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR20010041118A (ko) 2001-05-15
KR100608473B1 (ko) 2006-08-09
PL342357A1 (en) 2001-06-04
ATE280156T1 (de) 2004-11-15
US6780994B2 (en) 2004-08-24
ES2233023T3 (es) 2005-06-01
PT1056720E (pt) 2005-02-28
AU766411B2 (en) 2003-10-16
NZ506461A (en) 2003-08-29
CN1172911C (zh) 2004-10-27
HUP0100704A2 (hu) 2001-10-28
IL137953A0 (en) 2001-10-31
NO317104B1 (no) 2004-08-09
IL137953A (en) 2006-12-31
EP1056720B1 (en) 2004-10-20
WO1999042445A1 (en) 1999-08-26
JP2002503722A (ja) 2002-02-05
HK1031872A1 (en) 2001-06-29
US20030088099A1 (en) 2003-05-08
CN1291185A (zh) 2001-04-11
AU2776599A (en) 1999-09-06
US20020077476A1 (en) 2002-06-20
HUP0100704A3 (en) 2002-10-28
DE69921300T2 (de) 2006-03-09
NO20004142D0 (no) 2000-08-18
TR200003224T2 (tr) 2001-03-21
AR015521A1 (es) 2001-05-02
EP1056720A1 (en) 2000-12-06
ZA991319B (en) 2000-11-20
PL194649B1 (pl) 2007-06-29
DE69921300D1 (de) 2004-11-25
NO20004142L (no) 2000-10-19

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Free format text: JOHNSON & JOHNSON (US)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements