TR199900138T2 - Osteoporozun tedavisi için indolin türevleri. - Google Patents
Osteoporozun tedavisi için indolin türevleri.Info
- Publication number
- TR199900138T2 TR199900138T2 TR1999/00138T TR9900138T TR199900138T2 TR 199900138 T2 TR199900138 T2 TR 199900138T2 TR 1999/00138 T TR1999/00138 T TR 1999/00138T TR 9900138 T TR9900138 T TR 9900138T TR 199900138 T2 TR199900138 T2 TR 199900138T2
- Authority
- TR
- Turkey
- Prior art keywords
- sub
- alkyl
- optionally substituted
- group
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ra'nin, hidrojen, alkil veya tercihe göre ikameli aril olan R5 grubunu temsil ettigi, ve Rb'nin, X'in, alkil grubunun ikameli veya ikamesiz olabildigi bir hidroksi veya bir alkoksi grubunu temsil ettigi veya X'in, R8 ve Rt'nin her birinin bagimsiz olarak hidrojen, alkil, ikameli alkil, tercihe göre ikameli alkenil, aril, arilalkil, heterosiklik grup veya bir heterosiklikalkil grubunu temsil ettikleri veya Ra ile Rt'nin, bagli olduklari nitrojen ile birlikte bir heteroksiklik grubunu olusturduklari bir formül (a) kismini temsil ettigi; R1' in bir alkil veya ikameli ya da ikamesiz bir aril grubunu temsil ettigi; ve R2,R3 ile R4'ün herbirinin bagimsiz olarak hidrojen, alkil, aril veya ikameli aril'i temsil ettikleri; R6 ve R7' nin herbirinin bagimsiz olarak hidrojen, hidroksi, amino, alkoksi, tercihe göre ikameli ariloksi, tercihe göre ikameli benziloksi, alkilamino dialkilamino, halo, triflorometil, triflorometoksi, nitro, alkil, karboksi, karbaloksi, karbamoyl, (DEVAMI VAR)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9614367.2A GB9614367D0 (en) | 1996-07-09 | 1996-07-09 | Novel compounds |
GBGB9626697.8A GB9626697D0 (en) | 1996-12-23 | 1996-12-23 | Novel compounds |
GBGB9626700.0A GB9626700D0 (en) | 1996-12-23 | 1996-12-23 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199900138T2 true TR199900138T2 (tr) | 1999-04-21 |
Family
ID=27268385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/00138T TR199900138T2 (tr) | 1996-07-09 | 1997-07-03 | Osteoporozun tedavisi için indolin türevleri. |
Country Status (21)
Country | Link |
---|---|
US (2) | US20020173659A1 (tr) |
EP (1) | EP0914321B1 (tr) |
JP (1) | JP2000514074A (tr) |
KR (1) | KR20000023646A (tr) |
AT (1) | ATE277037T1 (tr) |
AU (1) | AU3620597A (tr) |
BR (1) | BR9710230A (tr) |
CA (1) | CA2259598A1 (tr) |
CZ (1) | CZ3799A3 (tr) |
DE (1) | DE69730837T2 (tr) |
ES (1) | ES2229375T3 (tr) |
ID (1) | ID18181A (tr) |
IL (1) | IL127668A0 (tr) |
MA (1) | MA24349A1 (tr) |
NO (1) | NO990080D0 (tr) |
PE (1) | PE46699A1 (tr) |
PL (1) | PL330994A1 (tr) |
TR (1) | TR199900138T2 (tr) |
TW (1) | TW397684B (tr) |
UY (2) | UY24608A1 (tr) |
WO (1) | WO1998001443A1 (tr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0974584B1 (en) | 1997-02-21 | 2003-01-15 | Takeda Chemical Industries, Ltd. | Fused ring compounds, process for producing the same and use thereof |
HU226587B1 (en) * | 1998-05-15 | 2009-04-28 | Wyeth Corp | Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
GB9914371D0 (en) | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
SE9903610D0 (sv) * | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds II |
SE9903611D0 (sv) * | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds III |
SE9903760D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
DE10022925A1 (de) * | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
WO2002007721A2 (en) | 2000-07-20 | 2002-01-31 | Lauras As | Use of cox-2 inhibitors for preventing immunodeficiency |
MXPA03008143A (es) | 2001-03-09 | 2005-08-16 | Johnson & Johnson | Compuestos heterociclicos. |
JP2005510482A (ja) * | 2001-10-16 | 2005-04-21 | アストラゼネカ・アクチエボラーグ | 線維筋痛症候群の治療方法 |
WO2004022060A2 (en) | 2002-09-06 | 2004-03-18 | Janssen Pharmaceutica, N.V. | (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders |
JP4384052B2 (ja) * | 2002-11-25 | 2009-12-16 | エフ.ホフマン−ラ ロシュ アーゲー | インドリル誘導体 |
US6916852B2 (en) * | 2003-05-12 | 2005-07-12 | University Of Tennessee Research Foundation | Method for regulation of microvascular tone |
ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
EP1779848A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
EP1779849A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of septic shock |
WO2010144611A2 (en) * | 2009-06-10 | 2010-12-16 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
WO2012045451A1 (en) | 2010-10-05 | 2012-04-12 | Ludwig-Maximilians-Universitaet Muenchen | Novel therapeutic treatment of progranulin-dependent diseases |
CA2877474A1 (en) * | 2011-06-20 | 2012-12-27 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
US20230219881A1 (en) * | 2022-01-11 | 2023-07-13 | Compound Solutions Inc. | Synthesis of Spermidine, Spermine, and Free Bases Thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2038925A1 (en) * | 1990-03-26 | 1991-09-27 | Takashi Sohda | Indole derivatives, their production and use |
WO1993001280A1 (en) * | 1991-07-08 | 1993-01-21 | Roland Baron | Inhibition of proton pump in osteoclast cells |
JPH07223945A (ja) * | 1994-02-10 | 1995-08-22 | Snow Brand Milk Prod Co Ltd | 骨疾患治療剤 |
SK93297A3 (en) | 1995-01-10 | 1998-02-04 | Smithkline Beecham Spa | Indole derivatives, method for their producing, pharmaceutical comosition containing the same, and their use |
-
1997
- 1997-07-03 PL PL97330994A patent/PL330994A1/xx unknown
- 1997-07-03 DE DE69730837T patent/DE69730837T2/de not_active Expired - Lifetime
- 1997-07-03 WO PCT/EP1997/003577 patent/WO1998001443A1/en active IP Right Grant
- 1997-07-03 EP EP97932778A patent/EP0914321B1/en not_active Expired - Lifetime
- 1997-07-03 AU AU36205/97A patent/AU3620597A/en not_active Abandoned
- 1997-07-03 IL IL12766897A patent/IL127668A0/xx unknown
- 1997-07-03 CZ CZ9937A patent/CZ3799A3/cs unknown
- 1997-07-03 JP JP10504784A patent/JP2000514074A/ja not_active Ceased
- 1997-07-03 AT AT97932778T patent/ATE277037T1/de not_active IP Right Cessation
- 1997-07-03 BR BR9710230A patent/BR9710230A/pt not_active IP Right Cessation
- 1997-07-03 TR TR1999/00138T patent/TR199900138T2/tr unknown
- 1997-07-03 CA CA002259598A patent/CA2259598A1/en not_active Abandoned
- 1997-07-03 ES ES97932778T patent/ES2229375T3/es not_active Expired - Lifetime
- 1997-07-07 ID IDP972341A patent/ID18181A/id unknown
- 1997-07-07 PE PE1997000586A patent/PE46699A1/es not_active Application Discontinuation
- 1997-07-07 UY UY24608A patent/UY24608A1/es unknown
- 1997-07-07 MA MA24706A patent/MA24349A1/fr unknown
- 1997-07-08 TW TW086109710A patent/TW397684B/zh not_active IP Right Cessation
- 1997-12-05 UY UY24802A patent/UY24802A1/es unknown
-
1999
- 1999-01-08 KR KR1019997000099A patent/KR20000023646A/ko not_active Application Discontinuation
- 1999-01-08 NO NO990080A patent/NO990080D0/no not_active Application Discontinuation
-
2001
- 2001-12-04 US US10/005,491 patent/US20020173659A1/en not_active Abandoned
-
2002
- 2002-11-20 US US10/300,332 patent/US6903117B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0914321B1 (en) | 2004-09-22 |
IL127668A0 (en) | 1999-10-28 |
CA2259598A1 (en) | 1998-01-15 |
CZ3799A3 (cs) | 1999-08-11 |
UY24608A1 (es) | 1997-12-19 |
ATE277037T1 (de) | 2004-10-15 |
US6903117B2 (en) | 2005-06-07 |
EP0914321A1 (en) | 1999-05-12 |
ES2229375T3 (es) | 2005-04-16 |
AU3620597A (en) | 1998-02-02 |
NO990080L (no) | 1999-01-08 |
US20040010012A1 (en) | 2004-01-15 |
US20020173659A1 (en) | 2002-11-21 |
BR9710230A (pt) | 1999-08-10 |
MA24349A1 (fr) | 1998-07-01 |
KR20000023646A (ko) | 2000-04-25 |
UY24802A1 (es) | 2001-03-16 |
PE46699A1 (es) | 1999-06-12 |
WO1998001443A1 (en) | 1998-01-15 |
JP2000514074A (ja) | 2000-10-24 |
TW397684B (en) | 2000-07-11 |
PL330994A1 (en) | 1999-06-21 |
NO990080D0 (no) | 1999-01-08 |
ID18181A (id) | 1998-03-12 |
DE69730837D1 (de) | 2004-10-28 |
DE69730837T2 (de) | 2005-09-29 |
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