TN2017000534A1 - Antibodies that bind to sortilin and inhibit the binding of progranulin - Google Patents

Antibodies that bind to sortilin and inhibit the binding of progranulin

Info

Publication number
TN2017000534A1
TN2017000534A1 TNP/2017/000534A TN2017000534A TN2017000534A1 TN 2017000534 A1 TN2017000534 A1 TN 2017000534A1 TN 2017000534 A TN2017000534 A TN 2017000534A TN 2017000534 A1 TN2017000534 A1 TN 2017000534A1
Authority
TN
Tunisia
Prior art keywords
antibodies
progranulin
sortilin
bind
inhibit
Prior art date
Application number
TNP/2017/000534A
Other languages
English (en)
Inventor
Rønn Lars Biilmann
Søren Christensen
Jong Rob De
Jan Egebjerg
Arnout Gerritsen
Ibrahim Malik
Paul Parren
Jeffrey Stavenhagen
Den Brink Edward Van
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of TN2017000534A1 publication Critical patent/TN2017000534A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TNP/2017/000534A 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin TN2017000534A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Publications (1)

Publication Number Publication Date
TN2017000534A1 true TN2017000534A1 (en) 2019-04-12

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP/2017/000534A TN2017000534A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Country Status (35)

Country Link
US (6) US10479835B2 (https=)
EP (1) EP3322726B1 (https=)
JP (2) JP6979397B2 (https=)
KR (1) KR102778576B1 (https=)
CN (3) CN107849135A (https=)
AR (1) AR105335A1 (https=)
AU (1) AU2016292980B2 (https=)
BR (1) BR112018000771A2 (https=)
CA (1) CA2989739A1 (https=)
CL (2) CL2018000092A1 (https=)
CO (1) CO2017012988A2 (https=)
CR (1) CR20180002A (https=)
DO (1) DOP2018000014A (https=)
EA (1) EA201890038A1 (https=)
EC (1) ECSP18002725A (https=)
ES (1) ES3024469T3 (https=)
GB (1) GB201512215D0 (https=)
HR (1) HRP20250602T1 (https=)
HU (1) HUE071424T2 (https=)
IL (1) IL256503B (https=)
JO (1) JO3710B1 (https=)
MA (1) MA42440B1 (https=)
MX (1) MX2018000506A (https=)
NI (1) NI201800007A (https=)
PE (1) PE20181014A1 (https=)
PH (1) PH12018500100A1 (https=)
PL (1) PL3322726T3 (https=)
RS (1) RS66856B1 (https=)
RU (1) RU2735639C2 (https=)
SV (1) SV2018005613A (https=)
TN (1) TN2017000534A1 (https=)
TW (1) TWI760305B (https=)
UA (1) UA125136C2 (https=)
WO (1) WO2017009327A1 (https=)
ZA (1) ZA201708613B (https=)

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US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
MX2021012335A (es) * 2019-04-10 2021-11-12 Regeneron Pharma Anticuerpos humanos que se unen a ret y metodos de uso de los mismos.
PH12022551598A1 (en) * 2019-12-23 2023-11-20 Denali Therapeutics Inc Progranulin variants
BR112022026508A2 (pt) * 2020-06-24 2023-03-07 Prothena Biosciences Ltd Anticorpos que reconhecem sortilina
KR20250028349A (ko) 2022-06-23 2025-02-28 드라우프니르 바이오 에이피에스 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai

Also Published As

Publication number Publication date
CL2018000092A1 (es) 2018-07-06
AU2016292980A1 (en) 2018-01-18
RU2018100824A3 (https=) 2020-01-17
CO2017012988A2 (es) 2018-05-21
EA201890038A1 (ru) 2018-06-29
MX2018000506A (es) 2018-05-11
JP2022003058A (ja) 2022-01-11
JP2018529635A (ja) 2018-10-11
US11548950B2 (en) 2023-01-10
MA42440B1 (fr) 2025-05-30
MA42440A (fr) 2018-05-23
US20200190188A1 (en) 2020-06-18
DOP2018000014A (es) 2018-04-15
HUE071424T2 (hu) 2025-08-28
PE20181014A1 (es) 2018-06-26
CN114478774A (zh) 2022-05-13
HRP20250602T1 (hr) 2025-07-18
ZA201708613B (en) 2021-03-31
HK1254356A1 (en) 2019-07-19
TWI760305B (zh) 2022-04-11
JP6979397B2 (ja) 2021-12-15
US20250277040A1 (en) 2025-09-04
CN107849135A (zh) 2018-03-27
CL2020002468A1 (es) 2021-01-29
US20210269524A1 (en) 2021-09-02
CN114478775A (zh) 2022-05-13
EP3322726A1 (en) 2018-05-23
UA125136C2 (uk) 2022-01-19
IL256503B (en) 2022-02-01
PL3322726T3 (pl) 2025-06-23
US10479835B2 (en) 2019-11-19
KR102778576B1 (ko) 2025-03-07
TW201702273A (zh) 2017-01-16
EP3322726C0 (en) 2025-03-12
US10428147B2 (en) 2019-10-01
KR20180030045A (ko) 2018-03-21
US20230159643A1 (en) 2023-05-25
US12331123B2 (en) 2025-06-17
RU2018100824A (ru) 2019-08-13
NI201800007A (es) 2018-10-18
PH12018500100A1 (en) 2018-07-30
AU2016292980B2 (en) 2022-10-06
BR112018000771A2 (pt) 2018-09-25
GB201512215D0 (en) 2015-08-19
ES3024469T3 (en) 2025-06-04
AR105335A1 (es) 2017-09-27
US20180305455A1 (en) 2018-10-25
RU2735639C2 (ru) 2020-11-05
RS66856B1 (sr) 2025-06-30
IL256503A (en) 2018-02-28
US20170267761A1 (en) 2017-09-21
ECSP18002725A (es) 2018-03-31
JO3710B1 (ar) 2021-01-31
WO2017009327A1 (en) 2017-01-19
EP3322726B1 (en) 2025-03-12
CR20180002A (es) 2018-04-09
US10889650B2 (en) 2021-01-12
CA2989739A1 (en) 2017-01-19
SV2018005613A (es) 2018-02-23

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