BR112018000771A2 - anticorpos que se ligam à sortilina e inibem a ligação de progranulina, composições farmacêuticas, preparações dos mesmos, uso de anticorpos, kit e método de prevenção ou tratamento de uma doença associada a níveis diminuídos de pgrn - Google Patents

anticorpos que se ligam à sortilina e inibem a ligação de progranulina, composições farmacêuticas, preparações dos mesmos, uso de anticorpos, kit e método de prevenção ou tratamento de uma doença associada a níveis diminuídos de pgrn

Info

Publication number
BR112018000771A2
BR112018000771A2 BR112018000771-4A BR112018000771A BR112018000771A2 BR 112018000771 A2 BR112018000771 A2 BR 112018000771A2 BR 112018000771 A BR112018000771 A BR 112018000771A BR 112018000771 A2 BR112018000771 A2 BR 112018000771A2
Authority
BR
Brazil
Prior art keywords
antibodies
pgrn
sortilin
preparations
bind
Prior art date
Application number
BR112018000771-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Christian Biilmann Rønn Lars
John Malik Ibrahim
B. STAVENHAGEN Jeffrey
Christensen Søren
Egebjerg Jan
Gerritsen Arnout
Van Den Brink Edward
Parren Paul
De Jong Rob
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BR112018000771A2 publication Critical patent/BR112018000771A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112018000771-4A 2015-07-13 2016-07-12 anticorpos que se ligam à sortilina e inibem a ligação de progranulina, composições farmacêuticas, preparações dos mesmos, uso de anticorpos, kit e método de prevenção ou tratamento de uma doença associada a níveis diminuídos de pgrn BR112018000771A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1512215.3A GB201512215D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
GB1512215.3 2015-07-13
PCT/EP2016/066516 WO2017009327A1 (en) 2015-07-13 2016-07-12 Antibodies that bind to sortilin and inhibit the binding of progranulin

Publications (1)

Publication Number Publication Date
BR112018000771A2 true BR112018000771A2 (pt) 2018-09-25

Family

ID=54013862

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018000771-4A BR112018000771A2 (pt) 2015-07-13 2016-07-12 anticorpos que se ligam à sortilina e inibem a ligação de progranulina, composições farmacêuticas, preparações dos mesmos, uso de anticorpos, kit e método de prevenção ou tratamento de uma doença associada a níveis diminuídos de pgrn

Country Status (35)

Country Link
US (6) US10479835B2 (https=)
EP (1) EP3322726B1 (https=)
JP (2) JP6979397B2 (https=)
KR (1) KR102778576B1 (https=)
CN (3) CN107849135A (https=)
AR (1) AR105335A1 (https=)
AU (1) AU2016292980B2 (https=)
BR (1) BR112018000771A2 (https=)
CA (1) CA2989739A1 (https=)
CL (2) CL2018000092A1 (https=)
CO (1) CO2017012988A2 (https=)
CR (1) CR20180002A (https=)
DO (1) DOP2018000014A (https=)
EA (1) EA201890038A1 (https=)
EC (1) ECSP18002725A (https=)
ES (1) ES3024469T3 (https=)
GB (1) GB201512215D0 (https=)
HR (1) HRP20250602T1 (https=)
HU (1) HUE071424T2 (https=)
IL (1) IL256503B (https=)
JO (1) JO3710B1 (https=)
MA (1) MA42440B1 (https=)
MX (1) MX2018000506A (https=)
NI (1) NI201800007A (https=)
PE (1) PE20181014A1 (https=)
PH (1) PH12018500100A1 (https=)
PL (1) PL3322726T3 (https=)
RS (1) RS66856B1 (https=)
RU (1) RU2735639C2 (https=)
SV (1) SV2018005613A (https=)
TN (1) TN2017000534A1 (https=)
TW (1) TWI760305B (https=)
UA (1) UA125136C2 (https=)
WO (1) WO2017009327A1 (https=)
ZA (1) ZA201708613B (https=)

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GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai
EP3666281A1 (en) * 2018-12-14 2020-06-17 Insusense ApS Compositions comprising sortilin-1
MX2021012335A (es) * 2019-04-10 2021-11-12 Regeneron Pharma Anticuerpos humanos que se unen a ret y metodos de uso de los mismos.
PH12022551598A1 (en) * 2019-12-23 2023-11-20 Denali Therapeutics Inc Progranulin variants
BR112022026508A2 (pt) * 2020-06-24 2023-03-07 Prothena Biosciences Ltd Anticorpos que reconhecem sortilina
KR20250028349A (ko) 2022-06-23 2025-02-28 드라우프니르 바이오 에이피에스 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途
WO2025031098A1 (zh) * 2023-08-09 2025-02-13 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体、含有其的重组aav及应用
WO2025132764A1 (en) * 2023-12-21 2025-06-26 Amylonix Ab A sortilin-binding polypeptide

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GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai

Also Published As

Publication number Publication date
CL2018000092A1 (es) 2018-07-06
AU2016292980A1 (en) 2018-01-18
RU2018100824A3 (https=) 2020-01-17
CO2017012988A2 (es) 2018-05-21
EA201890038A1 (ru) 2018-06-29
MX2018000506A (es) 2018-05-11
TN2017000534A1 (en) 2019-04-12
JP2022003058A (ja) 2022-01-11
JP2018529635A (ja) 2018-10-11
US11548950B2 (en) 2023-01-10
MA42440B1 (fr) 2025-05-30
MA42440A (fr) 2018-05-23
US20200190188A1 (en) 2020-06-18
DOP2018000014A (es) 2018-04-15
HUE071424T2 (hu) 2025-08-28
PE20181014A1 (es) 2018-06-26
CN114478774A (zh) 2022-05-13
HRP20250602T1 (hr) 2025-07-18
ZA201708613B (en) 2021-03-31
HK1254356A1 (en) 2019-07-19
TWI760305B (zh) 2022-04-11
JP6979397B2 (ja) 2021-12-15
US20250277040A1 (en) 2025-09-04
CN107849135A (zh) 2018-03-27
CL2020002468A1 (es) 2021-01-29
US20210269524A1 (en) 2021-09-02
CN114478775A (zh) 2022-05-13
EP3322726A1 (en) 2018-05-23
UA125136C2 (uk) 2022-01-19
IL256503B (en) 2022-02-01
PL3322726T3 (pl) 2025-06-23
US10479835B2 (en) 2019-11-19
KR102778576B1 (ko) 2025-03-07
TW201702273A (zh) 2017-01-16
EP3322726C0 (en) 2025-03-12
US10428147B2 (en) 2019-10-01
KR20180030045A (ko) 2018-03-21
US20230159643A1 (en) 2023-05-25
US12331123B2 (en) 2025-06-17
RU2018100824A (ru) 2019-08-13
NI201800007A (es) 2018-10-18
PH12018500100A1 (en) 2018-07-30
AU2016292980B2 (en) 2022-10-06
GB201512215D0 (en) 2015-08-19
ES3024469T3 (en) 2025-06-04
AR105335A1 (es) 2017-09-27
US20180305455A1 (en) 2018-10-25
RU2735639C2 (ru) 2020-11-05
RS66856B1 (sr) 2025-06-30
IL256503A (en) 2018-02-28
US20170267761A1 (en) 2017-09-21
ECSP18002725A (es) 2018-03-31
JO3710B1 (ar) 2021-01-31
WO2017009327A1 (en) 2017-01-19
EP3322726B1 (en) 2025-03-12
CR20180002A (es) 2018-04-09
US10889650B2 (en) 2021-01-12
CA2989739A1 (en) 2017-01-19
SV2018005613A (es) 2018-02-23

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