TN2009000184A1 - Modified soluble fgf receptor fc fusions with improved biological activity - Google Patents

Modified soluble fgf receptor fc fusions with improved biological activity

Info

Publication number
TN2009000184A1
TN2009000184A1 TNP2009000184A TN2009000184A TN2009000184A1 TN 2009000184 A1 TN2009000184 A1 TN 2009000184A1 TN P2009000184 A TNP2009000184 A TN P2009000184A TN 2009000184 A TN2009000184 A TN 2009000184A TN 2009000184 A1 TN2009000184 A1 TN 2009000184A1
Authority
TN
Tunisia
Prior art keywords
fgf receptor
fusions
biological activity
modified soluble
improved biological
Prior art date
Application number
TNP2009000184A
Other languages
English (en)
Inventor
Mark Nesbit
Beatrice Cameron
Francis Blanche
Sylvie Sordello
Celine Nicolazzi
Marc Trombe
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39431092&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000184(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of TN2009000184A1 publication Critical patent/TN2009000184A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/32Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TNP2009000184A 2006-11-28 2009-05-08 Modified soluble fgf receptor fc fusions with improved biological activity TN2009000184A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06291824 2006-11-28
EP07290042 2007-01-11
PCT/IB2007/004354 WO2008065543A2 (fr) 2006-11-28 2007-11-28 Fusions de fc récepteur de fgf soluble modifié, ayant une activité biologique améliorée

Publications (1)

Publication Number Publication Date
TN2009000184A1 true TN2009000184A1 (en) 2010-10-18

Family

ID=39431092

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000184A TN2009000184A1 (en) 2006-11-28 2009-05-08 Modified soluble fgf receptor fc fusions with improved biological activity

Country Status (33)

Country Link
US (3) US8119770B2 (fr)
EP (1) EP2092069B2 (fr)
JP (1) JP2010510801A (fr)
KR (1) KR20090102769A (fr)
AR (1) AR063975A1 (fr)
AT (1) ATE509106T1 (fr)
AU (1) AU2007326985C1 (fr)
BR (1) BRPI0719290A2 (fr)
CA (1) CA2668932A1 (fr)
CL (1) CL2007003411A1 (fr)
CO (1) CO6190564A2 (fr)
CR (1) CR10777A (fr)
CY (1) CY1112435T1 (fr)
DK (1) DK2092069T3 (fr)
EA (1) EA018700B1 (fr)
EC (1) ECSP099361A (fr)
GT (1) GT200900137A (fr)
HR (1) HRP20110503T1 (fr)
IL (1) IL198480A0 (fr)
MA (1) MA31143B1 (fr)
MX (1) MX2009005692A (fr)
MY (1) MY145914A (fr)
NI (1) NI200900097A (fr)
NO (1) NO20092414L (fr)
PE (1) PE20081250A1 (fr)
PL (1) PL2092069T3 (fr)
PT (1) PT2092069E (fr)
RS (1) RS51911B (fr)
SI (1) SI2092069T1 (fr)
SV (1) SV2009003272A (fr)
TN (1) TN2009000184A1 (fr)
TW (1) TW200839012A (fr)
WO (1) WO2008065543A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2536918A1 (fr) 2003-08-26 2005-03-03 Leland Shapiro Compositions et procedes pour molecules de fusion fc de l'alpha-1 antitrypsine
EP2083081A1 (fr) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Compositions et procédés pour traiter une maladie avec des protéines de fusion FGFR
WO2010017198A2 (fr) 2008-08-04 2010-02-11 Five Prime Therapeutics, Inc. Mutéines de région acide de domaine extracellulaire de fgfr
WO2011034940A1 (fr) 2009-09-15 2011-03-24 Five Prime Therapeutics, Inc. Méthodes de croissance des cheveux utilisant les domaines extracellulaires de fgfr4
PL2498799T3 (pl) * 2009-11-13 2017-03-31 Five Prime Therapeutics, Inc. Zastosowanie białek domeny zewnątrzkomórkowej FGFR1 do leczenia nowotworów charakteryzujących się mutacjami aktywującymi zależnymi od ligandów w FGFR2
WO2011084711A2 (fr) 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Procédés favorisant la pousse des cheveux à l'aide des domaines extracellulaires de fgfr3
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
MX2013005388A (es) 2010-11-15 2013-11-04 Five Prime Therapeutics Inc Terapias de combinadas de dominio extracelular del receptor del factor de crecimiento de fibroblastos 1 (fgfr1).
AU2015258172B2 (en) * 2010-11-15 2017-01-12 Five Prime Therapeutics, Inc. Fgfr1 extracellular domain combination therapies
US8951972B2 (en) * 2010-12-09 2015-02-10 Five Prime Therapeutics, Inc. FGFR1 extracellular domain combination therapies for lung cancer
CA2820781A1 (fr) 2010-12-23 2012-06-28 Sanofi Proteine hybrides robo1-fc a utiliser dans traitement d'hepatocarcinomes
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
CN102219860B (zh) * 2011-05-20 2012-09-12 烟台荣昌生物工程有限公司 FGFR-Fc融合蛋白及其用途
CN102219859B (zh) * 2011-05-20 2012-09-12 烟台荣昌生物工程有限公司 拮抗血管新生诱导因子的融合蛋白及其用途
AU2012272636A1 (en) * 2011-06-24 2013-05-02 Advent Bio Holdings Llc Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
CN107823630A (zh) 2011-11-14 2018-03-23 戊瑞治疗有限公司 治疗癌症的方法
AU2013202648B2 (en) 2012-01-10 2016-05-19 Konkuk University Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2014111744A1 (fr) 2013-01-16 2014-07-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Polypeptide de récepteur 3 du facteur de croissance fibroblastique (fgr3) soluble pour l'utilisation dans la prévention ou le traitement de troubles du retard de croissance squelettique
BR112015021423A2 (pt) 2013-03-06 2017-07-18 Genentech Inc métodos de tratamento de câncer, de células de câncer e de câncer resistente a antagonista de egfr, métodos de aumento da sensibilidade e da eficácia de tratamento de câncer e métodos de atraso, de tratamento de indivíduos com câncer e de extensão
EP3424956A1 (fr) * 2013-03-11 2019-01-09 Genzyme Corporation Polypeptides de liaison hyperglycosylés
US9957313B2 (en) 2013-03-15 2018-05-01 Remegen, Ltd. FGFR-FC fusion proteins and the use thereof
KR102049990B1 (ko) 2013-03-28 2019-12-03 삼성전자주식회사 c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
KR20160013092A (ko) * 2013-05-23 2016-02-03 파이브 프라임 테라퓨틱스, 인크. 암을 치료하는 방법
NZ715201A (en) 2013-08-01 2021-12-24 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies
US10995148B2 (en) 2014-03-19 2021-05-04 Genzyme Corporation Site-specific glycoengineering of targeting moieties
CN107073121A (zh) 2014-06-13 2017-08-18 基因泰克公司 治疗及预防癌症药物抗性的方法
SG10201913538VA (en) * 2015-11-23 2020-02-27 Five Prime Therapeutics Inc Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
SG10202112636SA (en) 2017-05-16 2021-12-30 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
WO2019106592A2 (fr) 2017-11-30 2019-06-06 Grifols Diagnostic Solutions Inc. Dosages immunologiques et protéines modifiées pour la surveillance de traitements par anticorps contre les inhibiteurs de points de contrôle immunitaires pd1 et pd-l1
EP3743437A1 (fr) * 2018-01-26 2020-12-02 F. Hoffmann-La Roche AG Protéines de fusion il-22 fc et procédés d'utilisation

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288856A (en) 1986-11-20 1994-02-22 Pierre Amiguet Method of isolating acid-stable, biologically active proteins
JP3040121B2 (ja) * 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US5750375A (en) * 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
US5147638A (en) 1988-12-30 1992-09-15 Oklahoma Medical Research Foundation Inhibition of tumor growth by blockade of the protein C system
US5288855A (en) * 1989-01-23 1994-02-22 Farmitalia Carlo Erba Extracellular form of the human fibroblast growth factor receptor
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5153310A (en) * 1989-02-28 1992-10-06 Du Pont Merck Pharmaceutical Company Il-2 analogs containing n-linked glycosylation sites
EP0481000B1 (fr) 1989-07-06 1999-05-12 The Regents Of The University Of California Recepteurs pour facteurs de croissance de fibroblastes
CA2080008C (fr) * 1990-04-27 2002-07-02 Koichi Igarashi Muteine hydrosoluble du recepteur de facteur de croissance des fibrolastes
US5349053A (en) * 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
AU662107B2 (en) 1990-07-06 1995-08-24 Aventis Pharmaceuticals Inc. Fibroblast growth factor receptors
US5541087A (en) * 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
US20020045207A1 (en) * 1997-10-31 2002-04-18 Lynne A. Krummen Glycoprotein production process
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
AU3224700A (en) * 1999-02-08 2000-08-25 Chiron Corporation Fibroblast growth factor receptor-immunoglobulin fusion
US6612152B2 (en) * 1999-05-01 2003-09-02 James E. Keaton Lifting, servicing, and diagnosing automobiles
US6656738B1 (en) * 1999-11-17 2003-12-02 Bae Systems Integrated Defense Solutions Inc. Internal heater for preconcentrator
EP1299535A2 (fr) * 2000-06-30 2003-04-09 Maxygen Aps Polypeptides glycosyles a extension peptidique
EP3263702A1 (fr) * 2000-10-06 2018-01-03 Kyowa Hakko Kirin Co., Ltd. Compositions d'anticorps produisant des cellules
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
AU2003217912A1 (en) * 2002-03-01 2003-09-16 Xencor Antibody optimization
EP1498490A4 (fr) 2002-04-09 2006-11-29 Kyowa Hakko Kogyo Kk Procede de production de composition anticorps
EP1498491A4 (fr) * 2002-04-09 2006-12-13 Kyowa Hakko Kogyo Kk Procede d'amelioration de l'activite d'une composition d'anticorps de liaison avec le recepteur fc gamma iiia
CN101987871A (zh) * 2002-09-27 2011-03-23 赞科股份有限公司 优化的Fc变体及其产生方法
US20050239088A1 (en) 2003-05-16 2005-10-27 Shepard H M Intron fusion proteins, and methods of identifying and using same
WO2005035741A1 (fr) * 2003-10-09 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. Cellule a genome modifie
DE102004022895A1 (de) 2004-05-10 2005-12-08 Adam Opel Ag Schallabsorbierendes Verkleidungselement
AU2005272993B2 (en) 2004-07-15 2010-02-11 Xencor, Inc Optimized Fc variants
US20060223147A1 (en) * 2004-08-05 2006-10-05 Kyowa Hakko Kogyo Co., Ltd., Process for producing glycoprotein composition
WO2006047350A2 (fr) 2004-10-21 2006-05-04 Xencor, Inc. Variants d'immunoglobuline igg a fonction effectrice optimisee
WO2006105338A2 (fr) 2005-03-31 2006-10-05 Xencor, Inc. Variants fc presentant des proprietes optimisees
US20060234347A1 (en) 2005-04-13 2006-10-19 Harding Thomas C Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors
EP1746161A1 (fr) * 2005-07-20 2007-01-24 Cytheris IL-7 glycosylée, préparation et utilisations
EP2083081A1 (fr) * 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Compositions et procédés pour traiter une maladie avec des protéines de fusion FGFR
WO2007041635A2 (fr) 2005-10-03 2007-04-12 Xencor, Inc. Variants de fc dotés de propriétés de liaison aux récepteurs fc optimisées

Also Published As

Publication number Publication date
DK2092069T3 (da) 2011-08-29
HRP20110503T1 (hr) 2011-08-31
BRPI0719290A2 (pt) 2014-02-25
SI2092069T1 (sl) 2011-09-30
AR063975A1 (es) 2009-03-04
MY145914A (en) 2012-05-15
US20120195851A1 (en) 2012-08-02
US20100061979A1 (en) 2010-03-11
EP2092069A2 (fr) 2009-08-26
CR10777A (es) 2009-07-23
AU2007326985A1 (en) 2008-06-05
MX2009005692A (es) 2009-10-12
PE20081250A1 (es) 2008-10-07
MA31143B1 (fr) 2010-02-01
US8119770B2 (en) 2012-02-21
NI200900097A (es) 2010-01-26
WO2008065543A3 (fr) 2008-08-14
KR20090102769A (ko) 2009-09-30
NO20092414L (no) 2009-08-21
PT2092069E (pt) 2011-07-29
AU2007326985C1 (en) 2014-02-20
JP2010510801A (ja) 2010-04-08
TW200839012A (en) 2008-10-01
CL2007003411A1 (es) 2008-07-04
US20140030265A1 (en) 2014-01-30
CA2668932A1 (fr) 2008-06-05
CO6190564A2 (es) 2010-08-19
WO2008065543A2 (fr) 2008-06-05
GT200900137A (es) 2011-09-02
EP2092069B2 (fr) 2013-12-18
EP2092069B1 (fr) 2011-05-11
IL198480A0 (en) 2011-08-01
EA018700B1 (ru) 2013-10-30
ATE509106T1 (de) 2011-05-15
RS51911B (en) 2012-02-29
US8481487B2 (en) 2013-07-09
CY1112435T1 (el) 2015-12-09
AU2007326985B2 (en) 2013-08-15
EA200970515A1 (ru) 2009-12-30
SV2009003272A (es) 2010-02-05
PL2092069T3 (pl) 2011-10-31
ECSP099361A (es) 2009-06-30

Similar Documents

Publication Publication Date Title
TN2009000184A1 (en) Modified soluble fgf receptor fc fusions with improved biological activity
MX2009007290A (es) Compuestos agonistas del receptor de la proteina 1 similar al glucagon.
MX2013007392A (es) Anticuerpo modificado con vida media mejorada.
WO2011091078A3 (fr) Variants d'anticorps possédant une activité complémentaire accrue
SI1629011T1 (sl) Humane molekule za vezavo anti hu cd
WO2007146139A3 (fr) Molécules d'adn optimisées au niveau des codons codant pour les domaines de liaison avec le récepteur des toxines a et b
WO2008147143A3 (fr) Protéines de fusion d'immunoglobuline
WO2005089224A3 (fr) Agents arni ciblant le facteur de croissance de l'endothelium vasculaire (vegf)
GB2455449A (en) Activatable binding polypeptides and methods of indentifcation and use thereof
WO2006116260A3 (fr) Modulation de la fonction d'effecteur d'anticorps par ingenierie de domaine 'charniere'
WO2007136893A3 (fr) Anticorps anti fgf19 et leurs méthodes d'utilisation
WO2008060705A8 (fr) Anticorps anti-dll4 et leurs procédés d'utilisation
WO2009071696A3 (fr) Molécules d'anticorps humanisés spécifiques pour il-31
NZ591471A (en) Antibodies to ccr2
ATE555202T1 (de) Verfahren zur lieferung von rna-interferenz und verwendungen damit
MX2012003939A (es) Fusiones y conjugados de farmaco.
WO2007112193A3 (fr) Conjugués de groupements se liant à la camptothécine
CL2009001258A1 (es) Polipeptido multivalente que comprende dos dominios de fibronectina tipo iii, ligados por un polipeptido de engarce basado en glicina-serina o glicina-prolina.
WO2008091798A3 (fr) Anticorps de ca9 optimises et methodes d'utilisation associees
MX2009004167A (es) Anticuerpos que enlazan epitopos cxcr7.
WO2009001840A1 (fr) Anticorps anti-prominine-1 à activité adcc ou activité cdc
WO2007075899A8 (fr) Composes agonistes doubles et leur utilisation
DOP2009000115A (es) Funciones fc con receptor para fgf soluble modificadas, con actividad biologica mejorada
WO2007053570A3 (fr) Complexe polypeptidique de trpm8 et de calmoduline et tissus correspondants
ZA202213707B (en) Bispecific antibody and use thereof