CO6190564A2 - Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada - Google Patents
Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejoradaInfo
- Publication number
- CO6190564A2 CO6190564A2 CO09053830A CO09053830A CO6190564A2 CO 6190564 A2 CO6190564 A2 CO 6190564A2 CO 09053830 A CO09053830 A CO 09053830A CO 09053830 A CO09053830 A CO 09053830A CO 6190564 A2 CO6190564 A2 CO 6190564A2
- Authority
- CO
- Colombia
- Prior art keywords
- fusion
- fgf
- receptor
- modified soluble
- fgf receptor
- Prior art date
Links
- 230000004071 biological effect Effects 0.000 title 1
- 230000004927 fusion Effects 0.000 abstract 15
- 108091008794 FGF receptors Proteins 0.000 abstract 13
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 abstract 13
- 102000005962 receptors Human genes 0.000 abstract 5
- 108020003175 receptors Proteins 0.000 abstract 5
- 230000004988 N-glycosylation Effects 0.000 abstract 4
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 abstract 2
- 125000005629 sialic acid group Chemical group 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 125000005630 sialyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Una fusión Fc con receptor para FGF soluble modificada que comprende una fusión de un fragmento o dominio solubles de un receptor para FGF con una región Fc de una inmunoglobulina, en donde al menos el 5° sitio de N-glicosilación de la porción de receptor para FGF está ocupado, y como máximo 45% de los N-glicanos de dicha porción de receptor para FGF no tienen grupo sialilo. 2.- La fusión Fc con receptor para FGF soluble modificada, según la reivindicación 1, en la cual, además, el 3er, 4°, 6° y 7° sitios de N-glicosilación de la porción de receptor para FGF están ocupados. 3.- La fusión Fc con receptor para FGF soluble modificada, según la reivindicación 2, en la cual al menos 7 sitios de N-glicosilación de la porción de receptor para FGF están ocupados. 4.- La fusión Fc con receptor para FGF soluble modificada, según la reivindicación 3, en la cual todos los sitios de N-glicosilación de la porción de receptor para FGF están ocupados. 5.- La fusión Fc con receptor para FGF soluble modificada, según cualquiera de las reivindicaciones precedentes, en la cual el número medio de ácidos siálicos por N-glicano de la porción de receptor para FGF es 0,9 o superior. 6.- La fusión Fc con receptor para FGF soluble modificada, según la reivindicación 5, en la cual el número medio de ácidos siálicos por N-glicano de la porción de receptor para FGF es 1,2 o superior. 7.- La fusión Fc con receptor para FGF soluble modificada, según cualquiera de las reivindicaciones precedentes, en la cual el valor KD de dicha fusión hacia FGF2, medido mediante BiacoreTM, está comprendido entre 1 y 5 nM.8.- La fusión Fc con receptor para FGF soluble modificada, según la reivindicación 7, en la cual el valor KD de dicha fusión hacia FGF2, medido mediante BiacoreTM, está en torno a 1,5 nM.9.- La fusión Fc con receptor para FGF soluble modificada, según cualquiera de las reivindicaciones precedentes, en la cual dicha fusión posee actividades de ADCC y/o CDC.10.- La fusión Fc con receptor para FGF soluble modificada, según cualquiera de las reivindicaciones precedentes, en la cual los N-glicanos de dicha fusión están fucosilados en un 60-100%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06291824 | 2006-11-28 | ||
| EP07290042 | 2007-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190564A2 true CO6190564A2 (es) | 2010-08-19 |
Family
ID=39431092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09053830A CO6190564A2 (es) | 2006-11-28 | 2009-05-26 | Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US8119770B2 (es) |
| EP (1) | EP2092069B2 (es) |
| JP (1) | JP2010510801A (es) |
| KR (1) | KR20090102769A (es) |
| AR (1) | AR063975A1 (es) |
| AT (1) | ATE509106T1 (es) |
| AU (1) | AU2007326985C1 (es) |
| BR (1) | BRPI0719290A2 (es) |
| CA (1) | CA2668932A1 (es) |
| CL (1) | CL2007003411A1 (es) |
| CO (1) | CO6190564A2 (es) |
| CR (1) | CR10777A (es) |
| CY (1) | CY1112435T1 (es) |
| DK (1) | DK2092069T3 (es) |
| EA (1) | EA018700B1 (es) |
| EC (1) | ECSP099361A (es) |
| GT (1) | GT200900137A (es) |
| HR (1) | HRP20110503T1 (es) |
| IL (1) | IL198480A0 (es) |
| MA (1) | MA31143B1 (es) |
| MX (1) | MX2009005692A (es) |
| MY (1) | MY145914A (es) |
| NI (1) | NI200900097A (es) |
| NO (1) | NO20092414L (es) |
| PE (1) | PE20081250A1 (es) |
| PL (1) | PL2092069T3 (es) |
| PT (1) | PT2092069E (es) |
| RS (1) | RS51911B (es) |
| SI (1) | SI2092069T1 (es) |
| SV (1) | SV2009003272A (es) |
| TN (1) | TN2009000184A1 (es) |
| TW (1) | TW200839012A (es) |
| WO (1) | WO2008065543A2 (es) |
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| PL2520654T3 (pl) | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| DE602006010874D1 (de) | 2005-07-22 | 2010-01-14 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
| AU2009279806B2 (en) | 2008-08-04 | 2015-04-30 | Five Prime Therapeutics, Inc. | FGFR extracellular domain acidic region muteins |
| US8445445B2 (en) | 2009-09-15 | 2013-05-21 | Five Prime Therapeutics, Inc. | Method of promoting hair growth using FGFR4 extracellular domains |
| EP2498799B1 (en) * | 2009-11-13 | 2016-08-17 | Five Prime Therapeutics, Inc. | Use of fgfr1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in fgfr2 |
| US8685931B2 (en) | 2009-12-17 | 2014-04-01 | Five Prime Therapeutics, Inc. | Hair growth methods using FGFR3 extracellular domains |
| FR2958936A1 (fr) | 2010-04-14 | 2011-10-21 | Sanofi Aventis | Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs |
| MX2013005388A (es) * | 2010-11-15 | 2013-11-04 | Five Prime Therapeutics Inc | Terapias de combinadas de dominio extracelular del receptor del factor de crecimiento de fibroblastos 1 (fgfr1). |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| AU2015258172B2 (en) * | 2010-11-15 | 2017-01-12 | Five Prime Therapeutics, Inc. | Fgfr1 extracellular domain combination therapies |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| UY33833A (es) | 2010-12-23 | 2012-07-31 | Sanofi Sa | Proteína de fusión Robo1-Fc para su uso en el tratamiento del hepatocarcinoma |
| AR085302A1 (es) * | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
| CN102219859B (zh) | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
| CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
| CA2839917A1 (en) * | 2011-06-24 | 2012-12-27 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| CN104168915A (zh) * | 2011-11-14 | 2014-11-26 | 戊瑞治疗有限公司 | 治疗癌症的方法 |
| KR20140137347A (ko) | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| WO2014111744A1 (en) | 2013-01-16 | 2014-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders |
| EP2964260A2 (en) | 2013-03-06 | 2016-01-13 | F. Hoffmann-La Roche AG | Methods of treating and preventing cancer drug resistance |
| EP4063389A3 (en) * | 2013-03-11 | 2022-12-28 | Genzyme Corporation | Site-specific antibody-drug conjugation through glycoengineering |
| US9957313B2 (en) | 2013-03-15 | 2018-05-01 | Remegen, Ltd. | FGFR-FC fusion proteins and the use thereof |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| AU2014268519A1 (en) * | 2013-05-23 | 2015-11-05 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
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| US20060223147A1 (en) * | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
| WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
| CA2602663A1 (en) | 2005-03-31 | 2006-10-05 | Xencor, Inc. | Fc variants with optimized properties |
| US20060234347A1 (en) | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| EP1746161A1 (en) * | 2005-07-20 | 2007-01-24 | Cytheris | Glycosylated IL-7, preparation and uses |
| DE602006010874D1 (de) | 2005-07-22 | 2010-01-14 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
| EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
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2007
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