SU984405A3 - Способ получени @ - @ -аминокислот - Google Patents
Способ получени @ - @ -аминокислот Download PDFInfo
- Publication number
- SU984405A3 SU984405A3 SU802919350A SU2919350A SU984405A3 SU 984405 A3 SU984405 A3 SU 984405A3 SU 802919350 A SU802919350 A SU 802919350A SU 2919350 A SU2919350 A SU 2919350A SU 984405 A3 SU984405 A3 SU 984405A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydrolysis
- hydroxyphenyl
- phenyl
- hydantoin
- pseudomonas
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 150000007650 D alpha amino acids Chemical class 0.000 title abstract 2
- 229940091173 hydantoin Drugs 0.000 claims abstract description 11
- 230000007062 hydrolysis Effects 0.000 claims abstract description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 10
- 108090000790 Enzymes Proteins 0.000 claims abstract description 6
- 102000004190 Enzymes Human genes 0.000 claims abstract description 6
- 241000589774 Pseudomonas sp. Species 0.000 claims abstract description 5
- 244000005700 microbiome Species 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 12
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims description 10
- 239000006285 cell suspension Substances 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 7
- 241000589516 Pseudomonas Species 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- -1 phenylglycine hydantoins Chemical class 0.000 claims description 5
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims description 3
- 230000002906 microbiologic effect Effects 0.000 claims description 3
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000006301 indolyl methyl group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- ZGUNAGUHMKGQNY-UHFFFAOYSA-N alpha-phenylglycine Chemical compound OC(=O)C(N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-UHFFFAOYSA-N 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 7
- 150000001469 hydantoins Chemical class 0.000 abstract description 3
- FYWDUQCSMYWUHV-UHFFFAOYSA-N 3-chloro-5-hydroxypentan-2-one Chemical compound CC(=O)C(Cl)CCO FYWDUQCSMYWUHV-UHFFFAOYSA-N 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 239000011541 reaction mixture Substances 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 235000011121 sodium hydroxide Nutrition 0.000 description 8
- 238000005119 centrifugation Methods 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 229940024606 amino acid Drugs 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 5
- LJCWONGJFPCTTL-SSDOTTSWSA-N D-4-hydroxyphenylglycine Chemical compound [O-]C(=O)[C@H]([NH3+])C1=CC=C(O)C=C1 LJCWONGJFPCTTL-SSDOTTSWSA-N 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 239000003456 ion exchange resin Substances 0.000 description 5
- 229920003303 ion-exchange polymer Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 description 4
- 229930182818 D-methionine Natural products 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical class [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- 238000005273 aeration Methods 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 229930182817 methionine Natural products 0.000 description 3
- 229960004452 methionine Drugs 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 239000012299 nitrogen atmosphere Substances 0.000 description 3
- 238000003918 potentiometric titration Methods 0.000 description 3
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 2
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Chemical compound CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229940099596 manganese sulfate Drugs 0.000 description 2
- 239000011702 manganese sulphate Substances 0.000 description 2
- 235000007079 manganese sulphate Nutrition 0.000 description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 description 1
- 229930182831 D-valine Natural products 0.000 description 1
- 102100036238 Dihydropyrimidinase Human genes 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 241000589771 Ralstonia solanacearum Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 108091022884 dihydropyrimidinase Proteins 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- ASHGTUMKRVIOLH-UHFFFAOYSA-L potassium;sodium;hydrogen phosphate Chemical compound [Na+].[K+].OP([O-])([O-])=O ASHGTUMKRVIOLH-UHFFFAOYSA-L 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7912285A FR2456728A1 (fr) | 1979-05-15 | 1979-05-15 | Procede de preparation de d-a-aminoacides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU984405A3 true SU984405A3 (ru) | 1982-12-23 |
Family
ID=9225470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU802919350A SU984405A3 (ru) | 1979-05-15 | 1980-05-14 | Способ получени @ - @ -аминокислот |
Country Status (11)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209495B (it) * | 1984-02-02 | 1989-08-30 | A San Donato Milanese Milano | Procedimento per la preparazione di l-alfa-amminoacidi. |
| JPS6356278A (ja) * | 1986-08-27 | 1988-03-10 | Nippon Soda Co Ltd | シユウドモナス属ｎｓ２１４菌及びｄ−アミノ酸の製造方法 |
| IT1276163B1 (it) | 1995-11-23 | 1997-10-27 | Eniricerche Spa | Procedimento migliorato per la preparazione di d-alfa-amminoacidi |
| IT1277125B1 (it) | 1995-12-21 | 1997-11-04 | Eniricerche Spa | Mutanti termostabili della d-n-alfa-carbamilasi |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1039757B (it) * | 1975-07-10 | 1979-12-10 | Snam Progetti | Complessi enzimatici atti a trasformare idantoine raceme in am minoacidi otticamente attivi e loro applicazione |
| JPS5344690A (en) * | 1976-02-04 | 1978-04-21 | Kanegafuchi Chem Ind Co Ltd | Preparation of d-n-carbamylphenylglycine and its substituted derivatives |
| US4211840A (en) * | 1977-06-08 | 1980-07-08 | Ajinomoto Company, Incorporated | Method for producing D-α-amino acid |
| JPS542398A (en) * | 1977-06-08 | 1979-01-09 | Ajinomoto Co Inc | Preparation of d-alpha-amino acid |
-
1979
- 1979-05-15 FR FR7912285A patent/FR2456728A1/fr active Granted
-
1980
- 1980-05-07 NL NL8002627A patent/NL8002627A/nl not_active Application Discontinuation
- 1980-05-13 GB GB8015758A patent/GB2051053B/en not_active Expired
- 1980-05-14 UA UA2919350A patent/UA5567A1/uk unknown
- 1980-05-14 SU SU802919350A patent/SU984405A3/ru active
- 1980-05-14 DE DE19803018584 patent/DE3018584A1/de not_active Ceased
- 1980-05-14 CH CH378980A patent/CH643299A5/fr not_active IP Right Cessation
- 1980-05-14 BE BE0/200638A patent/BE883322A/fr not_active IP Right Cessation
- 1980-05-14 SE SE8003630A patent/SE448883B/sv not_active IP Right Cessation
- 1980-05-15 IT IT22089/80A patent/IT1131185B/it active
- 1980-05-15 JP JP6465580A patent/JPS55153595A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH643299A5 (fr) | 1984-05-30 |
| JPS55153595A (en) | 1980-11-29 |
| GB2051053A (en) | 1981-01-14 |
| JPS6319158B2 (enrdf_load_stackoverflow) | 1988-04-21 |
| DE3018584A1 (de) | 1980-11-27 |
| SE8003630L (sv) | 1980-11-16 |
| FR2456728A1 (fr) | 1980-12-12 |
| BE883322A (fr) | 1980-11-14 |
| UA5567A1 (uk) | 1994-12-28 |
| NL8002627A (nl) | 1980-11-18 |
| IT8022089A0 (it) | 1980-05-15 |
| GB2051053B (en) | 1983-07-20 |
| SE448883B (sv) | 1987-03-23 |
| FR2456728B1 (enrdf_load_stackoverflow) | 1983-11-10 |
| IT1131185B (it) | 1986-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU599985B2 (en) | New process for the production of L-2-amino-4- (hydroxymethyl-phosphinyl)-butyric acid | |
| RU1806201C (ru) | Способ получени S(+) энантиомера 2-арилпропионовой кислоты | |
| CA1244788A (en) | Process for the production of l-carnitine and its derivatives | |
| SU984405A3 (ru) | Способ получени @ - @ -аминокислот | |
| SU469266A3 (ru) | Способ плучени 7-амино-дезацетоксицефалоспорановой кислоты | |
| JPH01320991A (ja) | Ｄ−ホモフエニルアラニン類の製造方法 | |
| GB2075026A (en) | Process for producing l-amino and oxidase | |
| EP0187525B1 (en) | Process for producing l-serine | |
| RU2143002C1 (ru) | СПОСОБ ПОЛУЧЕНИЯ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ | |
| JPS58116690A (ja) | Ｄ−β−ヒドロキシアミノ酸の製造法 | |
| JPS5928493A (ja) | アスパルチルフエニルアラニンアルキルエステルの製造法 | |
| JPS6356278A (ja) | シユウドモナス属ｎｓ２１４菌及びｄ−アミノ酸の製造方法 | |
| JP4020991B2 (ja) | Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法 | |
| JP2899071B2 (ja) | Ｌ―α―アラニンの製造法 | |
| JPH051716B2 (enrdf_load_stackoverflow) | ||
| SU1311256A1 (ru) | Консорциум дрожжей CaNDIDa тRорIсаLIS ЦМПМ У-507 и бактерий АсINетовастеR SpecIeS ЦМПМ В-3243-продуцент экзополисахарида | |
| JPH08245497A (ja) | Ｄ（−）−酒石酸の製造方法 | |
| JPH0254077B2 (enrdf_load_stackoverflow) | ||
| SU553283A1 (ru) | Способ получени алкогольдегидрогеназы | |
| JP2716477B2 (ja) | Ｓ‐カルボキシメチル‐ｌ‐システインの製造方法 | |
| JPH06102027B2 (ja) | Ｌ−２−アミノ−４−フェニル酪酸の製造方法 | |
| SU577229A1 (ru) | Способ получени гексокиназы | |
| JPS6243679B2 (enrdf_load_stackoverflow) | ||
| JPH0588118B2 (enrdf_load_stackoverflow) | ||
| JPH0424992B2 (enrdf_load_stackoverflow) |