SU841581A3 - Способ получени производных алкано-лАМиНА или иХ СОлЕй - Google Patents

Способ получени производных алкано-лАМиНА или иХ СОлЕй Download PDF

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Publication number
SU841581A3
SU841581A3 SU742029435A SU2029435A SU841581A3 SU 841581 A3 SU841581 A3 SU 841581A3 SU 742029435 A SU742029435 A SU 742029435A SU 2029435 A SU2029435 A SU 2029435A SU 841581 A3 SU841581 A3 SU 841581A3
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SU
USSR - Soviet Union
Prior art keywords
compound
formula
alkyl
group
alkoxy
Prior art date
Application number
SU742029435A
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English (en)
Inventor
Бернхард Бернтссон Педер
Элоф Брендстрем Арне
Ингемар Карлссон Энар
Эк Ларс
Роджер Самуэльссон Бенни
Эрик Сестранд Свен
Кристер Страндлунд Герт
Арне Хяльмар Аблад Бернт
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Аб Хессле (Фирма)
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Application filed by Аб Хессле (Фирма) filed Critical Аб Хессле (Фирма)
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Publication of SU841581A3 publication Critical patent/SU841581A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

Description

1
Изобретение относитс  к способу получени  производных алканоламина, обладающих формакологической активностью ,
Известны способы получени  различных производных алканоламина, которые как правило, наход т применение в медицине, в частности в ка1честве fiадренергических рецепторов.
Известен способ l получени  алканоламинов общей формулы
в сложный эфир оксигруппу, R имеет значение, указанное в формуле (1). Цель изобретени  - расширение ассортимента средств, воздействунидах на живой организм.
Поставленна  цель достигаетс  способом получени  алканоламинов общей формулы
-OCH,CHOHCH -NH-Rf (I)

Claims (1)

  1. Формула изобретения
    Способ получения производных алканоламина общей формулы
    ОСН2 СНОНСНг - NH - r' где R1 - изопропил;
    R2 - карбамоиламиноалкил, монои ди-алкилкарбамоюй1миноалкил , карба моиламиноалкоксил, мЬно- и ди-алкилкарбамоиламиноалкоксил, карбамоилоксиалкил, моно- и ди-алкилкарбамоилоксиалкил, карбамоилоксиалкоксил, м<> но- и ди-алкилкарбамоилоксиалкоксил, причем алкильные и алкоксильные труп пы содержат 1-3 атома углерода;
    R3 - водород, галоген, или их солей, отличающийс я тем, что соединение общей формулы
    ОСН^СНОНСНг NH2 где R2· и R3 имеют указанные значения, подвергают взаимодействию с соединением общей формулы Z-Rz , где R имеет указанные значения, a Z означает реакционноспособную этерифицированную в сложный эфир гидроксильную группу, с последующим выделением целевого продукта в свободном виде или в виде соли.
SU742029435A 1972-07-06 1974-06-03 Способ получени производных алкано-лАМиНА или иХ СОлЕй SU841581A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7208927A SE386892B (sv) 1972-07-06 1972-07-06 Forfarande for framstellning av oxaminoforeningar

Publications (1)

Publication Number Publication Date
SU841581A3 true SU841581A3 (ru) 1981-06-23

Family

ID=20275385

Family Applications (2)

Application Number Title Priority Date Filing Date
SU1933980A SU559642A3 (ru) 1972-07-06 1973-06-27 Способ получени алканоламинов или их солей в виде рацематов или оптически - активных антиподов
SU742029435A SU841581A3 (ru) 1972-07-06 1974-06-03 Способ получени производных алкано-лАМиНА или иХ СОлЕй

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU1933980A SU559642A3 (ru) 1972-07-06 1973-06-27 Способ получени алканоламинов или их солей в виде рацематов или оптически - активных антиподов

Country Status (22)

Country Link
US (1) US3930016A (ru)
JP (2) JPS5544740B2 (ru)
AR (2) AR205611A1 (ru)
AT (1) AT347475B (ru)
BE (1) BE801650A (ru)
CA (1) CA1088557A (ru)
CH (3) CH605698A5 (ru)
DE (1) DE2332837C2 (ru)
DK (1) DK137234B (ru)
ES (3) ES416605A1 (ru)
FI (1) FI63745C (ru)
FR (1) FR2191899B1 (ru)
GB (1) GB1436173A (ru)
HK (1) HK53679A (ru)
IE (1) IE38060B1 (ru)
IT (1) IT7950873A0 (ru)
MY (1) MY8000088A (ru)
NL (1) NL7309473A (ru)
NO (1) NO142033C (ru)
SE (1) SE386892B (ru)
SU (2) SU559642A3 (ru)
ZA (1) ZA733757B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
AT334385B (de) * 1973-12-20 1976-01-10 Chemie Linz Ag Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen
SE7402096L (ru) * 1974-02-18 1975-08-19 United Aircraft Corp
US4145363A (en) * 1975-02-05 1979-03-20 Yamanouchi Pharmaceutical Co., Ltd. 4-Carbamoylamino-α-aminomethylbenzyl alcohol derivatives
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4219561A (en) * 1977-09-22 1980-08-26 Imperial Chemical Industries Limited Alkanolamine derivatives
US4243681A (en) * 1977-10-11 1981-01-06 Mead Johnson & Company Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof
US4147805A (en) * 1978-07-28 1979-04-03 Mead Johnson & Company Alkylthiophenoxyalkylamines and the pharmaceutical use thereof
IT1147311B (it) * 1980-02-13 1986-11-19 Stabil Bioterapico Farmachim Eteri basici di 4-idrossi-benzofenoni con attivita' quali agenti betabloccanti e relativi procedimento di preparazione
SE8004088L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ...
JPS5832847A (ja) * 1981-08-20 1983-02-25 Mitsubishi Chem Ind Ltd （３−アミノプロポキシ）ビベンジル類
US4470965A (en) * 1982-10-27 1984-09-11 Usv Pharmaceutical Corporation Celiprolol for the treatment of glaucoma
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
EP0252007A3 (en) * 1986-06-28 1989-07-05 Ciba-Geigy Ag 2-propanol derivatives as corrosion inhibitors
SE8801518D0 (sv) * 1988-04-22 1988-04-22 Astra Pharma Prod A novel process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301580A (ru) * 1962-12-11
GB1199037A (en) * 1967-09-27 1970-07-15 Ici Ltd Alkanolamine Derivatives
US3466325A (en) * 1965-04-30 1969-09-09 Haessle Ab 1-(ortho-alkenyl phenoxy) - 2-hydroxy-3-isopropylaminopropanes and the salts thereof
SE372762B (ru) * 1969-05-21 1975-01-13 Haessle Ab

Also Published As

Publication number Publication date
IE38060B1 (en) 1977-12-21
ES416605A1 (es) 1976-06-16
NL7309473A (ru) 1974-01-08
DE2332837C2 (de) 1982-04-08
FR2191899A1 (ru) 1974-02-08
JPS54117437A (en) 1979-09-12
AU5758473A (en) 1975-01-09
BE801650A (fr) 1973-10-15
GB1436173A (en) 1976-05-19
FR2191899B1 (ru) 1977-08-19
SU559642A3 (ru) 1977-05-25
HK53679A (en) 1979-08-10
JPS4951232A (ru) 1974-05-18
NO142033B (no) 1980-03-10
FI63745B (fi) 1983-04-29
AR205611A1 (es) 1976-05-21
NO142033C (no) 1980-06-18
DE2332837A1 (de) 1974-01-24
ATA588973A (de) 1976-08-15
AR206214A1 (es) 1976-07-07
ES440955A1 (es) 1977-07-01
ZA733757B (en) 1974-08-28
IT7950873A0 (it) 1979-11-21
SE386892B (sv) 1976-08-23
AT347475B (de) 1978-12-27
CH598205A5 (ru) 1978-04-28
IE38060L (en) 1974-01-06
MY8000088A (en) 1980-12-31
CH605698A5 (ru) 1978-10-13
DK137234B (da) 1978-02-06
DK137234C (ru) 1978-07-10
US3930016A (en) 1975-12-30
CH599136A5 (ru) 1978-05-12
CA1088557A (en) 1980-10-28
FI63745C (fi) 1983-08-10
JPS5544740B2 (ru) 1980-11-13
JPS5630342B2 (ru) 1981-07-14
ES440954A1 (es) 1977-07-01

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