SU650499A3 - Способ получени аминоэфиров или их солей - Google Patents
Способ получени аминоэфиров или их солейInfo
- Publication number
- SU650499A3 SU650499A3 SU752162236A SU2162236A SU650499A3 SU 650499 A3 SU650499 A3 SU 650499A3 SU 752162236 A SU752162236 A SU 752162236A SU 2162236 A SU2162236 A SU 2162236A SU 650499 A3 SU650499 A3 SU 650499A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- group
- halogen
- general formula
- sulfonyloxy
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ АМИНОЭФИРОВ ИЛИ ИХ СОЛЕЙ
Предпочтительно процесс проводить в среде дипол рного апротонного растворител , например диметилсульфоксиде или диметилформамиде , и в присутствии третичного амина или в избытке исходного амина.
Целевой продукт выдел ют как в свободном виде, так и в виде соли, использу дл этого такие кислоты, как сол на , серна , азотна , уксусна , молочна , лимонна , малеинова , винна или этилендисульфокислота .
Пример. 5,95 г циклогексиламина раствор ют в 10 мм диметилсульфоксида, затем к нему добавл ют раствор 5,5 г р-хлорэтилового эфира 3,4,5-триметоксибензойной кислоты в 20 мл диметилсульфоксида. Реакционную смесь нагревают на вод ной бане в течение 8 ч и после этого концентрируют . Остаток обрабатывают хлороформом, промывают водой, и хлороформную фазу пасыпцают хлористым водородом. Высаженные эфиром кристаллы отфильтровывают и перекристаллизовывают из этанола. Получают Ы-2-оксиэтилциклогексиламино-3,4,5триметоксибензоатгидрохлорид с т. пл. 208-210°С.
Claims (3)
1. Способ получени аминоэфиров общей формулы
Ас - О - (Ш ) 2 гШ - СК(
В
где Ас - ди- или тризамещенна галогеном , нитро-, ОКСИ-, низшей алкокси- или сульфамоилгруппой бензоильна группа или ди- или тризамещенна низщей алкоксигруппой фенилацетилгруппа; А и В вместе с соседним атомом углерода образуют циклоалкилгруппу с 5-6 атомами углерода,
или их солей, отличающийс тем, что соединение общей формулы
Ас-О-{СН2)2-Y
где Ас - имеет указанные значени ,
Y - галоген, сульфонилокси- или аминогруппа ,
подвергают взаимодействию с соединением общей формулы
Х-СН
в
где А и В имеют указанные значени ;
X - аминогруииа, если Y - галоген или сульфонилоксигруппа, или X - галоген или сульфонилоксигруппа , если Y - аминогруппа, при температуре 50-130°С с последующим выделением целевого продукта в свободном виде или в виде соли.
2.Способ по п. 1, отл и ч а ю щи и с тем, что процесс провод т в дипол рном апротонном органическом растворителе, таком как диметилсульфоксид или диметилформамид .
3.Способ по пп. 1 и 2, отличающийс тем, что процесс провод т в присутствии
третичного амина или в избытке исходного амина.
Источники информации, прин тые во внимание при экспертизе 1. Бюлер К. и Пирсон Д. Органические синтезы. М., «Мир, 1970, с. 504-507.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI1231A HU165022B (ru) | 1972-04-28 | 1972-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU650499A3 true SU650499A3 (ru) | 1979-02-28 |
Family
ID=10994439
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1914706A SU539521A3 (ru) | 1972-04-28 | 1973-04-27 | Способ получени аминоэфиров или их солей |
| SU752159067A SU618036A3 (ru) | 1972-04-28 | 1975-07-23 | Способ получени аминов или их солей |
| SU752162236A SU650499A3 (ru) | 1972-04-28 | 1975-07-25 | Способ получени аминоэфиров или их солей |
| SU752162230A SU621314A3 (ru) | 1972-04-28 | 1975-07-25 | Способ получени аминов или их солей |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1914706A SU539521A3 (ru) | 1972-04-28 | 1973-04-27 | Способ получени аминоэфиров или их солей |
| SU752159067A SU618036A3 (ru) | 1972-04-28 | 1975-07-23 | Способ получени аминов или их солей |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU752162230A SU621314A3 (ru) | 1972-04-28 | 1975-07-25 | Способ получени аминов или их солей |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4010193A (ru) |
| JP (1) | JPS4954342A (ru) |
| AR (2) | AR203010A1 (ru) |
| AT (1) | AT336586B (ru) |
| BE (1) | BE798811A (ru) |
| BG (1) | BG22808A3 (ru) |
| CA (1) | CA985689A (ru) |
| CH (4) | CH589602A5 (ru) |
| DD (1) | DD107904A5 (ru) |
| DE (1) | DE2320378A1 (ru) |
| EG (1) | EG11264A (ru) |
| ES (4) | ES414148A1 (ru) |
| FR (1) | FR2183013B1 (ru) |
| GB (1) | GB1426514A (ru) |
| HU (1) | HU165022B (ru) |
| IL (1) | IL42101A (ru) |
| IN (1) | IN139005B (ru) |
| NL (1) | NL7305829A (ru) |
| NO (1) | NO137892C (ru) |
| PL (2) | PL96117B1 (ru) |
| SU (4) | SU539521A3 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5451244A (en) * | 1977-09-30 | 1979-04-21 | Sugiaki Kusatake | Cover for colored earth surface portion buried frame |
| US4619938A (en) * | 1984-03-21 | 1986-10-28 | Terumo Kabushiki Kaisha | Fatty acid derivatives of aminoalkyl nicotinic acid esters and platelet aggregation inhibitors |
| US5162344A (en) * | 1987-05-04 | 1992-11-10 | Robert Koch | Procaine double salt complexes |
| US5254686A (en) * | 1987-05-04 | 1993-10-19 | Robert Koch | Procaine double salt complexes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2339914A (en) * | 1940-11-29 | 1944-01-25 | Sharp & Dohme Inc | Chemical compound |
| US2421129A (en) * | 1944-06-22 | 1947-05-27 | Oradent Chemical Co Inc | Beta-isobutyl amino-beta, betadimethyl, ethyl benzoate |
| US2606205A (en) * | 1946-07-09 | 1952-08-05 | Wm S Merrell Co | Dihalogen benzoic acid esters of amino alcohols |
| US2767207A (en) * | 1953-10-30 | 1956-10-16 | Mizzy Inc | Beta (n-propylamino)beta, beta-dimethyl ethyl benzoate and its water-soluble salts |
| US2831016A (en) * | 1954-05-27 | 1958-04-15 | Univ Missouri | beta-substituted aminoalkyl 2,6-dialkylsubstituted benzoates and method of making the same |
| NL216318A (ru) * | 1957-04-13 | |||
| US2971018A (en) * | 1958-04-08 | 1961-02-07 | Seymour L Shapiro | Quaternary ammonium salts of (2-diethylamino-1-phenylethyl) benzoates |
-
1972
- 1972-04-28 HU HUCI1231A patent/HU165022B/hu unknown
-
1973
- 1973-04-19 AT AT348973A patent/AT336586B/de not_active IP Right Cessation
- 1973-04-21 DE DE2320378A patent/DE2320378A1/de active Pending
- 1973-04-25 DD DD170434A patent/DD107904A5/xx unknown
- 1973-04-25 FR FR7314926A patent/FR2183013B1/fr not_active Expired
- 1973-04-25 IL IL42101A patent/IL42101A/en unknown
- 1973-04-26 JP JP48047537A patent/JPS4954342A/ja active Pending
- 1973-04-26 US US05/354,732 patent/US4010193A/en not_active Expired - Lifetime
- 1973-04-26 NL NL7305829A patent/NL7305829A/xx not_active Application Discontinuation
- 1973-04-27 AR AR247755A patent/AR203010A1/es active
- 1973-04-27 CH CH430976A patent/CH589602A5/xx not_active IP Right Cessation
- 1973-04-27 ES ES414148A patent/ES414148A1/es not_active Expired
- 1973-04-27 CH CH605273A patent/CH590207A5/xx not_active IP Right Cessation
- 1973-04-27 NO NO1749/73A patent/NO137892C/no unknown
- 1973-04-27 GB GB2023373A patent/GB1426514A/en not_active Expired
- 1973-04-27 BE BE130489A patent/BE798811A/xx unknown
- 1973-04-27 CH CH430876A patent/CH589601A5/xx not_active IP Right Cessation
- 1973-04-27 CH CH431076A patent/CH589603A5/xx not_active IP Right Cessation
- 1973-04-27 SU SU1914706A patent/SU539521A3/ru active
- 1973-04-28 EG EG152/73A patent/EG11264A/xx active
- 1973-04-28 PL PL1973183230A patent/PL96117B1/pl unknown
- 1973-04-28 BG BG023460A patent/BG22808A3/xx unknown
- 1973-04-28 PL PL1973183231A patent/PL96131B1/pl unknown
- 1973-04-30 CA CA169,886A patent/CA985689A/en not_active Expired
- 1973-07-03 IN IN1553/CAL/73A patent/IN139005B/en unknown
-
1974
- 1974-06-18 AR AR254255A patent/AR199361A1/es active
-
1975
- 1975-07-23 SU SU752159067A patent/SU618036A3/ru active
- 1975-07-25 SU SU752162236A patent/SU650499A3/ru active
- 1975-07-25 SU SU752162230A patent/SU621314A3/ru active
- 1975-09-24 ES ES441244A patent/ES441244A1/es not_active Expired
- 1975-09-24 ES ES441243A patent/ES441243A1/es not_active Expired
- 1975-09-24 ES ES441242A patent/ES441242A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2320378A1 (de) | 1973-11-08 |
| ES414148A1 (es) | 1976-06-16 |
| PL96117B1 (pl) | 1977-12-31 |
| SU621314A3 (ru) | 1978-08-25 |
| GB1426514A (en) | 1976-03-03 |
| EG11264A (en) | 1977-12-31 |
| CH589603A5 (ru) | 1977-07-15 |
| IL42101A (en) | 1977-07-31 |
| AT336586B (de) | 1977-05-10 |
| AR199361A1 (es) | 1974-08-23 |
| CA985689A (en) | 1976-03-16 |
| CH589601A5 (ru) | 1977-07-15 |
| BG22808A3 (bg) | 1977-04-20 |
| ES441244A1 (es) | 1977-04-01 |
| IL42101A0 (en) | 1973-08-29 |
| ATA348973A (de) | 1976-09-15 |
| HU165022B (ru) | 1974-06-28 |
| NO137892C (no) | 1978-05-24 |
| SU618036A3 (ru) | 1978-07-30 |
| CH590207A5 (ru) | 1977-07-29 |
| NO137892B (no) | 1978-02-06 |
| JPS4954342A (ru) | 1974-05-27 |
| PL96131B1 (pl) | 1977-12-31 |
| AU5490973A (en) | 1974-10-31 |
| ES441242A1 (es) | 1977-04-01 |
| IN139005B (ru) | 1976-04-24 |
| SU539521A3 (ru) | 1976-12-15 |
| US4010193A (en) | 1977-03-01 |
| BE798811A (fr) | 1973-08-16 |
| FR2183013A1 (ru) | 1973-12-14 |
| CH589602A5 (ru) | 1977-07-15 |
| AR203010A1 (es) | 1975-08-08 |
| NL7305829A (ru) | 1973-10-30 |
| DD107904A5 (ru) | 1974-08-20 |
| FR2183013B1 (ru) | 1976-07-02 |
| ES441243A1 (es) | 1977-03-16 |
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